Tag Archives: lung

The many faces of macrophages in lung cancer

Lung cancer is the leading cause of cancer death worldwide, accounting for more deaths than breast, prostate, and colon cancer combined. Within the past decade, the role of the immune system in the development and progression of

Diminished disease-free survival following lung cancer surgery

Treatment of lung cancer requires removal of a portion of a vital organ, which may reduce life expectancy. This would be acceptable when surgery prevents death from cancer. It is harmful in cases identified by screening in

Specific danger signals associate with non-infection-related COPD exacerbations

Chronic Obstructive Pulmonary Disease (COPD) is a progressive and chronic lung disease, leading to difficulties with breathing for the patients. This is caused by the destruction of the lung sacs (alveoli), called emphysema and by inflammation of

Back to the future – looking at COPD with new eyes

Chronic obstructive pulmonary disease (COPD) is a broad term for diffuse lung disease caused by chronic inflammation of the airways. Patients with COPD become increasingly short of breath and often start to feel as if they are

Diagnosis of small cell lung carcinoma metastases

Cancer is defined by unscheduled cellular growth and metastatic spread into other organs of the body. Tumor cells gain their capacities form genetic alterations, also known as mutations, leading to altered protein functions and signaling pathways. Tumors

A central theory of biology

Like all sciences, Biology began with the systematic categorization of plants and animals, beginning with Linnaeus’s Binomial Nomenclature. That process was based on the appearance of organisms, which we know is subjective due to the way that

Using tumor DNA to refine lung cancer staging and treatment

The treatment of non-small cell lung cancer (NSCLC) is guided by disease stage as assessed by clinical and pathologic criteria.  Clinical tumor stage is determined by imaging including computed tomography (CT) scans, magnetic resonance imaging (MRI), positron

Specialised vesicle proteins which reduce the development of bacterial lung injury

Lung injury can occur from many stimuli including bacteria, asbestos and trauma. Injury occurs following breakdown of the barrier which lines blood vessels in the lungs. This breakdown forms gaps in lung vessels through which fluid and

Lung mechanics and pulmonary function testing in cetaceans

Marine mammals live a life of dual constraints. These air breathing animals need to spend time at the surface to replenish O2 used and remove CO2 produced by metabolism. However, food is underwater and the longer they

Many factors determine prognosis in resected lung cancer. Is visceral pleural involvement one of them?

Prognosis after pulmonary resection for primary lung cancer is closely related to tumor stage, since stage predicts the risk recurrence. Lung cancer staging is based on the TNM system that evaluates tumor size and contiguous tissue infiltration

In vivo imaging of the lung inflammatory response to Pseudomonas aeruginosa

Chronic inflammation of the airways is a central component in lung diseases and is frequently associated with bacterial infections. Monitoring the pro-inflammatory capability of bacterial virulence factors in vivo is challenging and usually requires invasive methods. The

Sponge toxin kills lung and breast cancer cells in mice

Peloruside A is a potent toxin that was isolated from a New Zealand marine sponge. It has a similar mechanism of action to the commonly used taxane-type anticancer drugs, including paclitaxel and docetaxel, that block the action

To beam or not to beam: Safely scanning mouse lungs for lung disease and therapy research

Lung diseases are among the most important causes of sickness and death in the world. Chronic obstructive pulmonary disease, lung fibrosis and emphysema are examples of such devastating and life-threatening conditions.  Doctors can help by relieving symptoms,

Potential for therapeutic intervention in lung diseases

The major function of the lung is to enable ambient oxygen uptake (essential for life) and eliminate carbon dioxide (a waste byproduct of metabolism) from the body. Surfactant protein A (SP-A), is a protein found in the

Nonsteroidal anti-inflammatory drugs attenuate lung carcinogenesis in smoking female mice

Chronic inflammation plays a crucial role in the development of cancer in general and of cigarette smoke (CS) – related lung cancer in particular. Accordingly, anti-inflammatory drugs, among which the extensively used nonsteroidal anti – inflammatory drugs

A method for studying mouse mammary tumorigenesis

Metastasis is the last step of primary breast cancer progression in which cells from the primary tumor leave and go to other organs. Breast cancer cells often metastasize to the lung, among other organs. Each step in