Tag Archives: mass spectrometry

Ultra Quick sample preparation prior to GC-MS based metabolomics

Metabolomics is a comprehensive study of low molecular weight compounds in biological samples and has been applied to wide range of research areas from medical to food analysis. For the analysis of metabolites, gas chromatography-mass spectrometry (GC/MS)

The T cell IFT20 interactome: new insights into immune synapse assembly regulation by the IFT system

T lymphocytes are key cellular components of the immune system that are essential for the elimination of viral, bacterial and parasitic infections as well as of malignant cells. T cell activation is initiated following recognition of pathogen-

Peculiar pollutants in the Moscow atmosphere in winter period: gas chromatography-high resolution time-of-flight mass spectrometry study

Moscow, Russia is one of the most populated cities in the world, with the metropolitan population reaching 12 million people. Moscow being also an important industrial center has several power plants, multiple industrial factories, waste incinerators, and

Determination of regions involved in amyloid fibril formation for Aβ(1-40) peptide

Mechanisms of amyloid formation of Aβ peptide are studied intensively. Determination of regions responsible for aggregation of the peptide and formation of amyloid fibrils is one of the primary aims in studying the formation of such structures.

Proteome view on how leukemia cells communicate with their environment to escape chemotherapy

Relapse continues to pose a major challenge to successful chemotherapy of adult acute myeloid leukemia (AML). Even though 80% of AML patients achieve remission, in which the bone marrow is virtually clear of leukemic cells, still almost

A new picture for an old biology, HDL as you’ve never seen it before

High-density lipoprotein (HDL) is known as good cholesterol since high levels of HDL are associated with lower risk of cardiovascular disease. Unlike its counterpart, low-density lipoprotein (LDL), whose actions are combatted by statins, clinical outcome trials for

Throwing a wrench into the hepatitis C replication machine

As an essential step in its replication cycle, the human hepatitis C virus (HCV) must make a copy of its RNA genome. The major player in this process is the NS5B polymerase, a molecular machine which uses

Combining paper-based electrochemistry and mass spectrometry

Electrochemistry / mass spectrometry ( EC / MS ) has many applications in science and industry such as drug discovery, elucidation of redox mechanisms, identification of drug metabolites, and online chemical derivatization for improving analytical figures of

Parallel Reaction Monitoring: A targeted mass spectrometry method

Mass spectrometry has emerged as a highly sensitive technique to study proteins and proteomes. Proteome is an entire repertoire of proteins in its various forms present in a cell, tissue or an organism. The study of proteome

Human exposures to Bisphenol A alternatives and derivatives with equal or more harmful effects

Recent years have witnessed an exponential interest in the use and research on bisphenol A (BPA). BPA is one of the chemicals ranked very high in the chemicals’ list with the highest production volume estimates worldwide. BPA

Rapid detection of cocaine in fingerprints using ambient mass spectrometry

Fingerprint residues, commonly referred to as fingerprints, are the result of an accumulation of sweat at the fingertips which is transferred to any surface upon contact. The composition of the fingerprint residue is therefore dependant on the

How to spot a sick cell?

Mass spectrometry (MS) is a technique used to measure the mass of molecules. Chemists extensively use this method to confirm that they have made the right molecule by comparing the mass of the actual product with the

Environmental contaminants as needles in a haystack

Detection of environmentally significant contaminants in very complex mixtures is a challenging problem for analytical chemists. A common approach uses gas chromatography (GC) to separate the mixture components in combination with mass spectrometry (MS) to identify the

Mass spectrometry for characterization of anti-theft devices directly from banknotes

The growth of bank and automated teller machine (ATM) thefts, particularly with the use of explosives, is a serious and increasing crime that has recently doubled in frequency in Brazil. Anti-theft security inks or anti-theft devices (ATDs)