Tag Archives: metabolism

A murine type 2 diabetes mellitus model mimicking metabolic characteristics similar to humans

Type 2 diabetes mellitus (T2DM) which accounts for more than 95% of all diabetes cases is a heterogeneous, multifactorial disorder typified by hyperglycemia with gradual decline in insulin action (insulin resistance), followed by the inability of beta

Antireductants – essential counterparts of antioxidants

The hype around ‘antioxidants for health’ largely overshadows the existence of antireductants. While antioxidants by definition decrease oxidative stress, antireductants decrease reductive stress (Fig. 1). Despite opposite reactivities, antioxidants and antireductants have in common that they are

A new picture for an old biology, HDL as you’ve never seen it before

High-density lipoprotein (HDL) is known as good cholesterol since high levels of HDL are associated with lower risk of cardiovascular disease. Unlike its counterpart, low-density lipoprotein (LDL), whose actions are combatted by statins, clinical outcome trials for

Effects of hypoxia/reoxygenation in the antioxidant system of crabs

Variations in the concentration of dissolved oxygen in water naturally induce hypoxia/reoxygenation cycles in various regions of aquatic environments of freshwater (rivers and lakes) and marine (coastal areas). However, in recent decades, human activities that discharge domestic

A simple assay to measure phosphatidylethanolamine methyltransferase activity

Enzymes are proteins that help chemical reactions to occur within cells and thus, they are essential to their life and function. They produce most of the molecules found in cells, and are classified by their function and

Biotransformation of bufadienolides in human liver microsomes

Bufadienolides are a family of cardiac aglycone compounds with the inhibitory activity of Na+/K+-ATPase. They exist extensively in both animal and plant species, such as Crassulaceae, Ranunculaceae, Bufonidae and Colubridae families. In traditional Chinese medicine, bufadienolides are

Polar bears and flame retardant chemicals as environmental pollutants

Polybrominated diphenyl ethers (PBDEs) are man-made chemicals that were used on many industrial and consumer products to reduce fire risk. The commercial PBDE mixture that was used extensively in North America for application to polyurethane foam, textiles

Can pharmacogenetics testing help reduce psychiatric suffering?

Pharmacogenetics testing is relatively new to the field of psychiatry having been introduced only within recent years and at an affordable cost in the clinical setting. The case history illustrated in this report describes how pharmacogenetics testing

A cancers addiction to glutamine affects the whole body and could lead to complex skin rashes

Signs or symptoms far from the vicinity of a developing cancer in the body can give clues of its presence (paraneoplastic syndromes). The skin can offer visible markers of abnormal metabolic activity caused by tumourigenesis, in the

Metabolism and pheochromocytoma/paraganglioma

Tumors are named according to the organ or the tissue whose cells undergo biological derangement causing the loss of the control mechanisms that normally limit cell growth. Therefore, breast tumors derives from the cells of the ducts of

A platform for measuring carbon and nitrogen levels of metabolism-related genes in durum wheat

Multiple lines of evidence confirm that as a result of human activities the greenhouse gas emissions are rising more rapidly than predicted and, consequently, the world is warming more quickly. Global climate change threatens for food security

A genetic switch for your health

We all have heard that reducing your caloric intake improves your health and may even extend your life. A fascinating aspect of calorie restriction is that it has similar beneficial effects in virtually all animal species tested.

What is really driving our need for food, besides the pleasure of taste?

We all know that this need is related, in some way, with life sustainability, but just how, exactly? The task of converting food into energy –and back again into organic compounds– is carried out by our metabolism,

HIV-1 pathology: when metabolism meets immunology

“We are what we eat” To this day, the human immunodeficiency virus type 1 (HIV-1) infection is still a public health problem with more than 33 million affected people worldwide with a growing number of cases. Immunology