Tag Archives: mice

Adolescent exposure of MDMA potentiates one of the hallmarks of Alzheimer’s disease

3,4 Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative widely consumed by adolescents, which has been described that produces oxidative stress in neurons such as dopaminergic neurons. Moreover, many patients with Alzheimer’s disease develop extrapyramidal symptoms due to alterations

Infections erode transplantation tolerance

Organ transplantation is an effective means of treating patients with organ failure, but rejection of the graft remains a major challenge. The life-long use of immunosuppressants needed to prevent rejection makes transplant recipients more susceptible to infections

Genetic and non-genetic animal models for Autism Spectrum Disorders

Autism spectrum disorder (ASD) is a heterogeneous group of neurobehavioral problems with genetic and environmental origins. The major neurobehavioral changes are manifested by persistent deficits in social and communication interaction, deficits in developing, understanding and maintaining relationships,

Viable RNase H1 knockout mice: The end of an enigma

Human cells have two RNase H enzymes, HI and H2. RNase H enzymes degrade RNA but only when an RNA strand is hybridized to a DNA strand forming an RNA-DNA heteroduplex. These enzymes are present in almost

Assessment of anxiety: a matter of temperature?

Anxiety is an emotional response occurring when individuals are facing challenging situations or threats. This affective state promotes adaptive coping strategies and is associated with changes involving a variety of different, cross-species conserved, behavioral and physiological responses

Why can MDMA produce memory deficits?

MDMA is a synthetic drug belonging to the amphetamine family and has both stimulant and hallucinogenic properties. These features have become MDMA in one of the most used drugs by young adolescents. Many studies have described that

Laboratory mice – ready-made for animal studies?

Laboratory animals, most of them mice, are bred and used to model human diseases. On one hand this offers great possibilities for science, one the other hand this topic is controversially debated. Beside ethical concerns, the major

Developing a sense of direction

Nervous systems continuously perform computations to create thoughts, feelings, and perceptions of the world. Circuits composed of neurons, which are the specialized cells of the nervous system, execute these calculations. To do so, neurons in a circuit receive input

Sponge toxin kills lung and breast cancer cells in mice

Peloruside A is a potent toxin that was isolated from a New Zealand marine sponge. It has a similar mechanism of action to the commonly used taxane-type anticancer drugs, including paclitaxel and docetaxel, that block the action

Nonsteroidal anti-inflammatory drugs attenuate lung carcinogenesis in smoking female mice

Chronic inflammation plays a crucial role in the development of cancer in general and of cigarette smoke (CS) – related lung cancer in particular. Accordingly, anti-inflammatory drugs, among which the extensively used nonsteroidal anti – inflammatory drugs

Genetically engineered mice provide a new look at sight-threatening eye disease

A group of sight-threatening inflammatory diseases of the eye, in which the immune system inappropriately recognizes and attacks the retina and adjacent structures, is known as non-infectious, or autoimmune, uveitis. Lymphocytes of the patients in fact recognize