Tag Archives: microRNA

Molecular mechanism of phenotypic plasticity

Darwinian evolution is considered to be the way that life adapts in every possible environment in Earth. The great evolutionary biologist of the past century Theodosius Dobzansky used to say: “Nothing in Biology Makes Sense Except in

Teasing apart the roles that oncogenic miRNAs play in breast cancer

Oncogenic miRNA and breast cancer Since the early 2000’s, the field of RNA has been contributing to major discoveries in cancer research. McroRNAs are small RNA molecules (miRNA), inhibit the messenger RNAs that produce our proteins. Normally,

MicroRNAs identify high-risk colon cancer patients

Choosing the optimal anticancer treatment for each patient requires proper disease staging. Staging is usually assessed according to the TNM system: tumour size (T), number of nearby lymph nodes affected (N), and metastasis, or spread to other

Mutations in the SHOX2 gene contribute to irregular heartbeats

Heart rhythm disorders contribute significantly to cardiovascular morbidity and mortality and represent a major health issue. Developing approaches towards disease prediction and treatment of cardiac arrhythmias is therefore an important topic in healthy aging. Atrial fibrillation (AFib)

Uncovering the microRNA landscape in the crop pest nematode Meloidogyne incognita

Plant-parasitic nematodes are small roundworms that predominantly feed on roots and cause crop yield losses. The root-knot nematode, Meloidogyne incognita is among the most damaging pests of several crops including cotton, tomato, and soybean. The infective stage

Silencing a microRNA may keep the doctor away for diabetic wounds

Patients with diabetes are frequently afflicted with impaired wound healing that may progress into chronic, diabetic ulcers, often leading to complications including limb amputation with increased risk of morbidity and mortality. These ulcers occur not only in

A new technique for quantification of small RNA variants with a single-nucleotide resolution

Non – protein – coding regions of the genome are widely transcribed to produce non – coding RNAs (ncRNAs), which play a crucial role in various biological processes and diseases. Recent advances in next-generation sequencing technologies have

How the immune system is regulated by small RNAs called microRNAs to prevent self-attacks leading to autoimmunity

The ability to properly engage the different arms of the immune response is essential for protection from pathogens but also for preventing autoimmune reactions against normal tissue. Central to autoimmune prevention are a class of white blood

Blocking miR-212/132 in T cells is a potential therapy for treating colitis

Inflammatory bowel diseases (IBD), which include Crohn’s disease and ulcerative colitis, is thought to be caused by aberrant immune response to host intestinal microbiota, leading inflammation in gastrointestinal tract. The symptoms such as diarrhea, rectal bleeding, anemia,

Can hypertension and related cardiovascular diseases be caused by Dark-Matter-like RNAs?

Hypertension is a common but one of the most important health problems, because it is a major risk factor for many cardiovascular diseases. Hypertension is a multi-factorial disease involving complex interplay of genetic and environmental factors. To treat