Tag Archives: model

Importance of updating prognostic predictions: an example from breast cancer

Today prognostic prediction models are an integral part of clinical practice in many fields. They are typically used to access the risk of an event in the future after a well-defined starting point, for instance the risk

Placental transfer of the HIV drug dolutegravir in a human ex vivo perfusion model

The fetus of an HIV-positive woman has a 25% chance of becoming infected during pregnancy. HIV medicines have shown to be highly effective in preventing fetal infection with HIV. A part of the efficacy but also the

Dispersion of particle emissions from quarries in complex terrain

Quarrying and surface mining operations are area sources of dust (suspended particles) that may cause considerable air pollution. Such sources, by their nature, are characterized by lack of detailed information about the location of the mobile mining

Whole-cell computational models can predict how genes influence behavior

Since the early 1900’s, scientists have known that cells are composed of multiple components, including small molecules, DNA, RNA, and protein. Over the past fifty years, scientists have systematically measured these individual components and their interactions. Despite

Properties of magnetic nanocomposites for biomedical applications

Polymer nanocomposites have been receiving a lot of attention in the field of biomedical engineering. These composite materials, which consist of a polymer as the matrix and nanoparticles (nano-sized particles) as fillers, offer the opportunity for the

Computational refinement and validation protocol for proteins

HIV protects itself using a membrane layer of lipids which covers all proteins which could potentially be targeted by drugs. The only exposed proteins, gp120 and gp41 form spikes that protrude out of the lipid membrane.  These

Use of an in vitro model of blastema tissue from Rabbit pinna

Rabbit ear wound repair is an accepted model for studies of tissue regeneration, leading to scar less wound repair. It is believed that a specific tissue, blastema, is responsible for such interesting capacity of tissue regeneration. To

Rapid prototyping to explain the biology of seahorse tails

Rapid prototyping employs the use of modern engineering tools, such as computer modeling and 3D-printing, to build physical models of new product design concepts. Applying similar techniques, our team of biologists and engineers built two 3D-printed models

Effect of resveratrol on chemotherapy of a fatal childhood cancer

The natural polyphenolic compound resveratrol, found in red wine, dark chocolate, and peanuts, may confer health benefits in humans. It is a powerful antioxidant that has been suggested to alleviate age-related pathologies, such as type II diabetes,

How my physician could adapt his or her behaviors to my preferences?

Nowadays, the recommended approach in physician – patient interaction is patient – centeredness. As the name suggests, patient – centeredness implies to put the patient in the center of the consultation and to take his or her

A new mouse model to study the biology of depression in cancer

Patients with advanced cancers often experience depression, which can significantly reduce their quality of life and increase mortality. Currently, the lack of a valid and useful animal model is the greatest obstacle for studying the basic biology

Osmoregulation in phytopathogenic fungi

Osmosis is a phenomenon in which water moves always from higher to lower chemical potential, commonly towards the area with higher solute concentration. Living cells are semi-closed systems with membranes permeable for water but not for many

Rat model of small opaque eyes open the door to eye research

Ocular diseases in elderly persons, such as cataract and age-related macular degeneration (AMD), one of the main causes of vision loss in developed nations, are paid great attention nowadays. The eye is a complicated organ constructed with

Using genome-scale models to predict biological capabilities

Rapid advances in DNA sequencing and synthesis technologies have revolutionized the study of life sciences. With these new technologies come new challenges. The massive amount of new data generated using these technologies must be curated, managed, and

Antiepileptic property of vitamin B12 in one animal model

Epilepsy –a serious neurological disorder that affects millions of people worldwide– is usually associated with a disturbance of normal activity of the brain, and in most typical form, is accompanied by seizures. Various antiepileptic drugs with different

Using ‘Big Data’ approaches to gain new insights into asthma

By combining fibre optic camera technology with the mathematics of ‘Big Data’ from Silicon Valley, researchers at Southampton have been with gaining new insights into the nature of the world’s commonest long-term lung disease: asthma. Up to