Tag Archives: neurotoxicity

Computer simulations predict the cause of a drug’s fatal neurotoxicity in a failed clinical trial

A new drug called BIA 10-2474, in development for pain management, caused severe side effects in a clinical trial in France in 2016. In the safety phase of the clinical trial, one healthy participant died from unexpected

Reversibility of Aβ oligomer neurotoxicity: Insights into the treatment of Alzheimer’s disease

Alzheimer’s disease (AD), the most common neurodegenerative dementia disorder, causes memory impairment and other cognitive deficits. AD is neuropathologically characterized by senile plaques and neurofibrillary tangles, which are composed of amyloid β-protein (Aβ) and phosphorylated tau proteins,

Can metal-exposure induce innate immune reactivity in brain cells and thus contribute to neurotoxicity?

Use of metals in dentistry is quite common for braces, crowns, fillings, implants. Problems sometimes occur, such as allergy, locally inflamed mucosae, or vague symptoms throughout the entire body. However, alternatives such as methacrylates will never completely