Tag Archives: oligomer

Determination of the size of folding nuclei of fibrils formed from Aβ(1-40) peptide

One of the most important models for studying amyloid fibril formation is the Aβ peptide, aggregates of which form plaques in the course of Alzheimer`s disease. Formation of Aβ aggregates goes through the nucleation mechanism with exponential

Small or big, brain cells don’t like protein gunk that lead to diseases like Alzheimer’s, Parkinson’s and Huntington’s

An interdisiciplinary study by scientists at Trinity College Dublin (TCD, Ireland) have answered a hotly debated question in the neurodegenerative diseases research area: “Which protein aggregate form is the primary pathogenic agent in neurodegenerative diseases – (i) the prefibrillar oligomeric