Tag Archives: oligomers

Cholesterol manipulation switches the production of “toxic Aβ” to “protective Aβ”

The amyloid hypothesis maintains that the pathogenesis of Alzheimer’s disease (AD) is driven by the production and accumulation of amyloid-β (Aβ) peptides in the brain. Consequently, many therapeutic strategies to reduce Aβ production have been examined. However,

A new trehalose-conjugated peptide protects neurons from Aβ’s oligomers insult

Alzheimer’s disease (AD) is by far the most common cause of dementia affecting more than 35 million people worldwide. AD is characterized by memory loss, dramatic impairment of cognitive skills, and progressive body and mind decline ultimately

Oligomers are building blocks of amyloid formation for insulin and its fast analog LisPro

The hormone insulin was discovered in 1921 by Banting and Best, and since that time it has been studied rigorously. At the same time first attempts were made to use insulin for treating diabetes. Insulin was the