Tag Archives: oncogenic

Oncogenic role of CircPVT1 in head and neck squamous cell carcinoma

Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs that have recently shown to behave as gene regulators in eukaryotic cells, extending our previous knowledge regarding the diversity and complexity of the transcriptome. Nowadays, circRNAs have

p53 gene reactivation reverts hypoxic resistance in KRAS mutant tumor cells decreasing glucose uptake

When growing distant from primary blood supply sites, tumor cells face hypoxia characterized by niches restricted in oxygen and glucose. Cells acquiring resistant to hypoxic stress undergo metabolic re – programming, and increased resistance to 3 –