Tag Archives: oxidative stress

The promiscuous mineralocorticoid receptor

Hormones and nerves are the key communication systems in the human body. Nerves are like a fixed-line telephone network, capable of very fast messaging: think of the pianist’s fingers playing the Minute Waltz. Hormones are like radio,

Fish responses to ocean acidification comes with a cost

Ocean acidification is currently recognized as a major threat to marine ecosystems and has become one of the fastest growing research fields in marine sciences. The excessive amount of anthropogenic carbon dioxide is making our oceans warmer

Nanodiamonds are just around the corner

The expansion of nanotechnology cause increased penetration of nanoparticles into the environment and their exposure of animals becomes inevitable. Consequently studies on their effects and potential toxicity is now gaining attention. Nanodiamonds (ND) are allotropes of carbon

Pathological role of oxidative stress and related with schizophrenia in T. gondii infection

Toxoplasma gondii (T. gondii) is an obligate intracellular parasite that infects all warm-blooded animals, including humans. Oxidative stress (OS) occurs when there is an imbalance between pro-oxidant and antioxidant factors and is induced by reactive nitrogen species

Neuroprotection for stroke: Progesterone treatment reduces brain mitochondrial dysfunction

Every year, six million people die from stroke and five million are left disabled. 80% of strokes are ischemic and happen when blood flow is blocked in a part of the brain, due to occlusion of brain

Blockade of estrogen receptor alpha mitigates alcohol-evoked myocardial dysfunction in female rats

Recent evidence challenges the longstanding view that light-to-moderate alcohol drinking might confer cardioprotection, and the latter is mostly based on population studies in men or in male experimental animals. However, while the reduction in blood pressure caused

Understanding the rare disease alkaptonuria: the role of oxidative stress, inflammation and amyloidosis

Alkaptonuria (AKU) is an ultra-rare disease that was recognized among the first inborn errors of metabolism. In AKU, an altered activity of the enzyme homogentisate 1,2-dioxygenase (HGD) occurring upon gene mutation lead to a defective metabolism of

Changes in 3-dimentional chromatin structure as a mean to relieve oxidative stress?

DNA in our cells is packaged into a structure called chromatin, which is mainly a protein-DNA complex. Chromatin needs to be loosened for fundamental processes to take place, such as decoding genetic information (i.e. gene expression) and

Cerium fluoride nanoparticles protect cells against oxidative stress

Nano-biomaterials engineering is one of today’s most promising areas of materials science. In very recent years, nanocrystalline cerium oxide (nanoceria) has been shown to possess enormous biological activity, which originates from its ability to scavenge the reactive

Withaferin-A, a phytochemical, has potential to reduce liver injury due to acetaminophen overdose

Acetaminophen (APAP), also known as paracetamol, is the most popular over-the-counter drug used for common illnesses such as head and body ache, cold and fever. When administered in therapeutic doses (≤ 4 grams/24 h for an adult),

ZNRF1: a key molecule activated by reactive oxygen species to cause neuronal degeneration

Neurons, the major component of our brain, have long processes (called “axons” and “dendrites”) to communicate with other neurons and cells. In many brain diseases that old people get suffered from, such as Alzheimer’s disease, Parkinson’s disease,

Updates on the pathophysiology of systemic sclerosis

Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with autoimmune component, inflammation, and progressive fibrosis of conjunctive tissues of the skin and internal organs. Lung involvements are a major cause of concern as pulmonary fibrosis and

Metallothionein, oxidative stress and trace metals in gills of liver of fish species

Kuwait Bay is important area that is influenced by the local municipal and industrial discharges. Therefore, two types of local fish from were studies, yellow finned seabream which is pelagic fish swim between the surface and the

Physical activity and diet: the two pillars of hercules for health and wellbeing

News by the World Health Organization over the past few days claimed that eating too much red meat has been related to health adverse events including shorter lifespan, cardiovascular disease, and cancers. Remembering Paracelso aphorism: “Sola dosis

Nanocarrier-based antioxidant therapy: promise or delusion?

It has been well established that the damage produced by Reactive Oxygen Species (ROS), which are highly reactive molecules with an unpaired electron, plays an important role in a large number of human diseases. Because of this

NEIL2 repairs DNA damage within active genes, maintains chromosome end integrity, prevents inflammation

Mammalian cells are subjected to a plethora of exogenous and endogenous agents that cause damage to the cellular DNA. One of the major sources of such damage is oxygen-derived molecules and free radicals, collectively termed “Reactive Oxygen