Tag Archives: Parkinson’s disease

Measuring motivation in Parkinson’s disease through the eyes response to money

Apathy or a lack of motivation is a disabling condition making patients feel that they “just can’t be bothered to do things”. Apathy is very common in Parkinson’s disease, affecting up to 70% of patients and causing

TRIM32 and alpha-synuclein: a novel interplay in the neuronal system

Parkinson’s disease (PD) is the second most common neurodegenerative disease mainly characterised by the progressive loss of nigrostriatal dopaminergic neurons, resulting in a series of motors symptoms and the formation of intracellular inclusions within the cells, known

‘HATs On’: A small molecule with big potential in epigenetic therapy for Parkinson’s disease

Parkinson’s disease (PD) is a common, progressive and age-related neurodegenerative disease, whose incidence is set to double by 2030 as people are living longer. At present, it is estimated that ten million people worldwide suffer with PD.

Promiscuous drugs exemplified by dopamine receptor ligands

Dopamine, often referred as “the happiness hormone”, is one of the most prominent messenger molecules in the human brain. It is a precursor of noradrenaline and adrenaline, which are neurotransmitters as well. Most people heard about dopamine

A systems-level view of cerebellar function: The interplay between cerebellum, basal ganglia, and cortex

The cerebellum is a key brain region involved in many motor functions. It contributes to coordination, precision, and accurate timing of movements as well as to motor learning and adaptation. Alongside its role in motor control, it

The environmental toxin BMAA detected in humans – Cause of neurodegenerative diseases?

Alzheimer´s disease, Parkinson´s disease and ALS ( amyotrophic lateral sclerosis ) are the most common neurodegenerative diseases in the world, and cause tremendous human suffering. Only about ten percent of the cases are hereditary, while the rest

Calcium disturbances in Parkinson’s disease

Parkinson’s disease is a common disorder of the brain that affects around 127,000 people in the UK alone. The disease is characterised by the loss of nerve cells (neurons) that control mobility. Symptoms include muscle stiffness, tremor

Targeted exercise intervention for bradykinesia in Parkinson’s disease

Exercise has been used as an intervention for many diseases; however, to maximize the benefits of any exercise intervention there we must understand that exercise is not a blunt, unidimensional tool; but rather, a malleable prescriptive instrument

The right tool for the right job – it is brain surgery after all!

Getting drugs into the brain to help treat cancer or neurological diseases like Parkinson’s or Alzheimer’s is pretty difficult. Generally speaking you can’t just take a pill or get an injection as the brain is protected by

Parkinson’s alpha-synuclein assembles in the disease prone stable dimers

The self – assembly of proteins into amyloid – type aggregates is a widespread phenomenon associated with many neurodegenerative diseases, including Parkinson’s disease (PD). According to the current model for PD, the aggregation of alpha-Synuclein (α-Syn) and

How antioxidants may have a pro-oxidant effect?

The main function of the consumption of antioxidants is to strengthen the activity of enzymatic antioxidant systems of our cells and this is intended to prevent or delay oxidative stress caused by the increase of reactive oxygen

Parkinson disease and duodenal levodopa infusion: why patients withdraw the treatment?

Parkinson disease is a chronic and progressive movement disorder associated to degeneration of neurons in the brain, particularly in a region called substantia nigra. These neurons produce dopamine, a neural transmitter that is involved in the control

How the marmoset can help us develop new therapies for Parkinson’s disease

New advances in the treatment of Parkinson’s disease heavily depend on valid animal models of the disease that allows for the evaluation of symptoms over extended time periods. The marmoset is a primate that shares several important features

Parkinsonism Hyperpyrexia Syndrome and Deep Brain Stimulation

Deep Brain Stimulation of the subthalamic nuclei (STN-DBS) represents one of the most effective treatments in patients with Parkinson’s disease (PD) with unsatisfactory response to pharmacological therapy. STN-DBS is a neurosurgical approach based on the implantation of

How reducing cell signalling protects neurons against synapse degeneration

Dementia is a clinical manifestation of Alzheimer’s disease, dementia with Lewy bodies and is seen in a high proportion of late stage Parkinson’s disease patients. The symptoms are associated with degeneration of synapses, the structures by which

Antidepressants associated with falls in Parkinson’s patients

Parkinson’s disease is a progressive neurological disorder that affects mobility and is commonly characterized, in advanced stages of the disease, by instability and falls. Falls are a major reason for hospitalization in Parkinson’s patients and may lead