Tag Archives: Prostate cancer

Understanding how liposome composition and manufacturing affect docetaxel encapsulation and cell killing

Docetaxel (DTX) belongs to a class of anticancer drugs clinically used to treat a plethora of cancers, including breast and prostate cancer. DTX works by interfering with the cell cycle and blocking cell proliferation. Although being a

Scientists don’t have to travel alone; solutions can come from the crowd

Science is sometimes perceived as a lonely affair where a lone genius strives to break the code that will unlock hidden knowledge deep inside the data. Without question the contributions of great scientists are of value, but

Application of ultrasensitive electrochemical biosensors for specific analysis of a glycan on a prostate-specific antigen

Prostate cancer (PCa) is the second most common cancer worldwide, accounting for more than 1.1 million cases in 2012.  The statistics says, that about 1 man in 7 will be diagnosed with PCa during his lifetime with

Alcohol and prostate cancer risk

In a large follow-up study, we found that heavy regular alcohol consumption and binge drinking during midlife were associated with a significantly increased risk of prostate cancer risk. Specifically, men who were heavy drinkers (>14 drinks/week) were

Focal salvage for radiorecurrent prostate cancer

Patients primarily treated with radiotherapy for prostate cancer can get a recurrence. The tumour then regrows. Often this is a localised process and the tumour has not spread to other parts of the body. Therefore, these patients

Androgen receptor; a tale of two cancers

Prostate cancer and breast cancer share similarities as hormone related cancers with a wide range of heterogeneous settings. Macklin, as early as 1954, provided evidence for a significantly higher frequency of prostate cancer among relatives of breast

Three dimensional quality assurance protocol for thoracic and genitourinary radiation therapy

After cancer diagnosis one treatment option is the use of external radiation. As the radiation traverses the patient it deposits most of its energy in the tumor, which causes irreparable damage to the cancer cells. One type

Ultrasensitive detection and glycan analysis of a prostate cancer biomarker

In recent years we have seen an increased frequency of diagnosed prostate cancer (PCa) cases accompanied with an enhanced mortality worldwide. Symptoms of an early-stage PCa can be mild or even absent, thus there is an urgent

Radiotherapy for prostate cancer: restrictions for the treatment of recurrent disease

Patients with prostate cancer who are treated with radiotherapy are not always cured. Depending on their pre-treatment risk factors (most importantly the stage of the tumour), they are at risk of recurrent disease. These recurrences often present

Rising from obscurity: 11β-hydroxy-androstenedione under the spotlight

Steroid hormones are small molecules that act as messengers in our bodies, regulating normal development and impacting on disease. These hormones are produced from cholesterol by the actions of enzymes− proteins which change cholesterol to form new

Undertreatment of men in their seventies with aggressive prostate cancer

Prostate cancer may be cured by either surgery or radiation treatment, but these “radical treatments” often cause permanent side effects that negatively affect the quality of life. Small prostate cancers usually grow very slowly, so more elderly

The protective role of estrogens in prostate cancer and its relationship with the SCF/c-KIT system

Prostate Cancer (PCa) is the most common oncological disorder in men worldwide, mainly affecting individuals over the age of 50. Therefore, the population aging and the improved expectancy of life have been contributing to the increased incidence

Regucalcin controls prostate cell proliferation and glycolytic metabolism

Regucalcin (RGN) is a protein with multiple functions and facets, which seems to play an important role in tissue cell homeostasis by regulating the equilibrium between cell survival/proliferation and death, and also in the control of cell

Treating prostate cancer with immunotherapy

Cancer immunotherapy induces the immune system to recognize and destroy cancer cells. These therapies can work through a number of ways but two of the most researched methods are therapeutic cancer vaccines and immune checkpoint inhibitors. Therapeutic

A novel radionuclide treatment for hormone refractory metastatic prostate cancer

Prostate cancer is the second most common male cancer worldwide and the fourth most common cancer overall. In patients with localized prostate cancer, the five-year survival rate approximates to 100%; however, in patients with distant metastases, it

Treatment sequencing in metastatic castrate-resistant prostate cancer

The treatment of metastatic castrate resistant prostate cancer (mCRPC) has been rapidly advancing. Years of research effort have culminated, in the approvals of five active agents that prolong patient survival. However, as a practicing clinician, I and