Tag Archives: protein

With a little help from friends: how plastids aid the ER to deal with misfolded proteins

Almost a third of all proteins in eukaryotic cells are synthesized and folded in the endoplasmic reticulum (ER) before being secreted and redistributed to other organelles, such as the Golgi apparatus, lysosomes, and the plasma membrane. To

Key elements of proteins involved in the bacterial production of the toxin methylmercury

Mercury is a prevalent global pollutant that has adverse effects on human health.  This toxin is present in the environment not only as a result of releases during natural events, such as volcanic eruptions, forest fires and

Do Bucentaur family proteins represent true monsters in the fight against stress?

The BCNT (Bucentaur) protein family, which is conserved from fungi to humans, is classified by the presence of an ~80 amino acid sequence at the C-terminus called BCNT-C. Family members in fungi, flies, fish, and chicken play

Arrestin-enolase protein complex as a new auto antigen in heart disease

Over the past two decades, evidence of a pathogenic relevance of autoimmunity in human heart disease has increased significantly. A central role for autoimmunity in a significant proportion of dilated cardiomyopathy (DCM) patients is supported by the

Yarrowia lipolytica: how a yeast becomes a workhorse for biotechnology

Yarrowia lipolytica is a yeast species belonging to the Ascomycota fungi phylum (like the well-known baker’s and brewer’s yeasts, both from Saccharomyces cerevisiae species). This innocuous yeast can be found in a large range of ecosystems (soils,

Targeted ion therapy using nanoparticles – a new direction

A living body is made of the smallest building block, called ‘cell’. It gives us a shape, helps us to perform physiological and biological activities, and so on. A eukaryotic cell contains a nucleus, buried in the

Antibodies at your pipette tips

Antibodies are essential in our immune system to fight against all sorts of diseases that we could encounter every day. The technological developments over the decade has allowed scientist to isolate target or disease-specific antibodies in the

Advancing medicine and agriculture using proteins that control energy and sugar production

Except for bacteria , most living organisms contain specialized cellular compartments termed mitochondria , that are responsible for breaking down sugars to produce energy for the cell. Plant cells possess a second compartment called chloroplasts , which

Dissecting how cells communicate to prevent cancer relapse

Protein kinases are a class of enzymes that are responsible for the transfer of phosphates onto other proteins. These phosphate groups, although small, can change the behaviour of the protein itself, or the behaviour of those it

Biodiesel synthesis in response to individual short chain fatty acids during mixotrophic mode of microalgal cultivation

Growing concern over fuel crisis and global climate change has led to substantial investment and research into alternative fuel sources. In this prospect, photosynthetic organisms have huge potential for biofuels production in a carbon neutral way with

Small or big, brain cells don’t like protein gunk that lead to diseases like Alzheimer’s, Parkinson’s and Huntington’s

An interdisiciplinary study by scientists at Trinity College Dublin (TCD, Ireland) have answered a hotly debated question in the neurodegenerative diseases research area: “Which protein aggregate form is the primary pathogenic agent in neurodegenerative diseases – (i) the prefibrillar oligomeric

Punching above their weight: how the smallest RNAs offer great promise for cancer biology

In recent decades, scientists have witnessed transformative developments in the field of RNA biology. RNA molecules are similar in composition to their more famous DNA counterparts (they are both nucleic acids), but are present in a variety

Computational refinement and validation protocol for proteins

HIV protects itself using a membrane layer of lipids which covers all proteins which could potentially be targeted by drugs. The only exposed proteins, gp120 and gp41 form spikes that protrude out of the lipid membrane.  These

How to know transcription factors by the company they keep

The ENCODE project is a massive data-collection effort set out to understand the function of the human genome. The collection comprises many types of genomic data, including the localization of transcription factors onto DNA. Transcription factors are

Allergy: the latest technology in vitro in the service of an appropriate diagnosis

The countless and various allergen sources from both the plant kingdom is to the animal kingdom constantly stimulate our immune system.So the allergy diagnostics laboratory is evolving using new technologies such as molecular biology, nanotechnology to highlight

A resource for studying the role of RNA-binding proteins in human disease

Advances in science and technology have not only made accessing and analyzing the personal genomic information a reality but also rapid and cost effective. Every living organism is made of cells and every cell is made of