Tag Archives: receptor

AntiVEGF therapy: hidden changes on heart and vessels

VEGF (Vascular endothelial growth factor) is a protein normally present in our organism that promotes the growth of new blood vessels, a process known as angiogenesis. Cancer cells produce this substance in large quantity, obtaining a continuous

Liver X receptor beta, the link between thyroid hormone regulation and the browning of white fat

Everyone agrees that when our intake of sugar, fat and protein exceeds the body’s need for nutrition, excess is stored as fat. Fat in the form of white adipocytes is the body’s reserve of energy, which is

Receptors as drug targets

According to the latest count, human body has 37.2 trillion cells. They all have the same genetic material, half deriving from a sperm cell, the other half from an egg cell. Consequently, all the cells are in

Sweetness of recombinant human lysozyme

Here, we reported that lysozyme found in human milk elicits sweet taste as well as chicken lysozyme with 20-folds more sweetness than sucrose by weight. Lysozyme is an enzyme that degrades the bacterial cell wall and thereby

The role of the thalamic submedius nucleus histamine in modulation of formalin-induced orofacial pain

Pain is one of the most common and disturbing of human experiences. While it has many causes, the appreciation of painful sensation depends on the stimulation of pain receptors (nociceptors) and the conduction of the nerve impulses

The binding of mGluR4 targeting drugs could help the finding novel treatments for PD

One of the key features of drugs is an ability to find the corresponding target molecule (eg. protein) from the body. The target protein has unique structural sites that could be loaded with specific chemicals (drugs). The

Evolution of innate T cells

As a part of adaptive immunity, T cells identify and respond to products or antigens derived from pathogens. These antigens are seen by T cells in the form of short fragments or peptides presented by classical major

The drug that can inhibit infection by reovirus

Cellular diversity is, to some extent, determined by the molecules present within specific cells. For example, cells that make up the endothelium, the part of blood vessels that come in contact with blood, make specific proteins that

A potential harmless food bio-preservative — pediocin PA-1

Food safety issues are always around us for food-borne pathogen and spoilage bacteria exist in many kinds of food. Chemical preservatives are added to prevent food spoilage, however, most of them are cancerogen and unsafe for us.

Characterizing the whac-a-mole concept of a bispecific antibody targeting cancer cells

One of the great promises of antibodies is to be magic bullets that specifically target diseased cells without affecting normal cells. Oncology researchers identify targets on tumor cells that are unique, overexpressed, or oncogenic drivers that can

Exploring the amazing capacity of many bacteria to swim towards specific chemicals

Many bacteria possess flagella, which are flexible filaments attached to the bacterial surface. These filaments can rotate which in turn propels the bacterium forward and enables them to swim. However, this swimming behavior does not simply occur

The number of AMPA receptors on the cell surface is abnormally increased in the brain of Cln3-knock-out mice

Nerve cells in the brain communicate with each other by electrical and chemical signals. The amino acid, glutamate is the main stimulatory chemical signal in the brain. When a nerve terminal releases glutamate, it binds and activates