Tag Archives: resistance

20th-century version of an old pathogen. Drug resistant tuberculosis

Mycobacterium tuberculosis the causative agent of human tuberculosis (TB) is consider the most successful pathogen  that could infect (2 billion), induce (10.4 million) and kill (1.7 million) a large number of people around the world. Besides this

Studying how hepatitis C virus resists certain drugs using computers and the internet

Hepatitis C virus (HCV) was not known to mankind until 1989. The discovery of this virus was possible due to the development of polymerase chain reaction (PCR) technology. Globally, around 180 million people are infected with this

Novel ROS1 mutations reveal a predictive mutational model for TKI sensitivity

In tumors with tumor-specific genetic alterations (i.e. 20-40% lung cancers), cancer cells are highly dependent on the function of a single oncogene, defined as ‘driver oncogene’ for their proliferation and survival. Many oncogene alterations have been identified

Simple mathematical formulas for tracking the number of antibiotic resistance cases globally

In order to continue to live, microbes and germs have found ways to prevent drugs from killing them in the process of curing patients—when the patients ingest the drugs for treatment. Microbes destroying drugs within patients and

Inhibitors that reduce the acquisition of antibiotic resistance

The rapid emergence of antibiotic resistance is a worldwide crisis, endangering the efficacy of antibiotic treatment. A recent article in Scientific America (December 16, 2014) highlights the importance of developing strategies for reducing antibiotic resistance and prolonging

Are disinfection processes an effective barrier in controlling the spread of antibiotic resistance in the environment?

According to the report on global surveillance of antimicrobial resistance published in 2014 by the World Health Organization (WHO), the world is heading towards a post-antibiotic era, in which common infections and minor injuries may once again

Fecal microbial transplantation: a novel approach to eradicate antibiotic-resistant gut bacteria

The discovery of antibiotics in the early 20th century had an enormous impact on modern medicine, dramatically reducing mortality associated with infections.  However, the emergence of drug – resistant pathogens has occurred due to greater availability and

Can solar driven processes effectively control antibiotic resistance and cytotoxicity during drinking water treatment?

Antibiotics, antibiotic resistant bacteria and antibiotic resistant genes have been detected in various aquatic environments because of the disposal of both treated and untreated wastewater. Their occurrence in water is a threat for human and animal health

Rapid and extremely reliable detection extended-spectrum ß-lactamases-producing Enterobacteriaceae

Resistance to antibiotics is becoming a worldwide issue mostly related to resistance observed in gram negative bacterial species such as in Enterobacteriaceae (Escherichia coli , Klebsiella pneumoniae) that are the most important source of hospital – and

Anthelmintic resistance or what left after the incorrect treatment?

Small ruminant gastrointestinal parasites represent very important and common problem in the world (Fig. 1). Infections with gastrointestinal nematodes can have a detrimental effect on animal health such as weight losses, diarrhea, anemia, digestion problems and even

Targeted exercise intervention for bradykinesia in Parkinson’s disease

Exercise has been used as an intervention for many diseases; however, to maximize the benefits of any exercise intervention there we must understand that exercise is not a blunt, unidimensional tool; but rather, a malleable prescriptive instrument

The antibacterials that have yet to be found

Science has contributed greatly to prolong the lifespan and health conditions of humans. However, close to the coming of age of the XXI Century, humankind is confronting the global war against infectious diseases. Leaving aside other microorganisms-associated

Plasmid-mediated carbapenem and colistin resistance in E. coli – toward a dead end

The increasing trend in antibiotic resistance continues to threaten global health. Presently, multidrug resistance (MDR) in gram-negative rods is frequently observed not only with the occurrence of extended-spectrum ß – lactamase but also with producers of enzymes

Fatty liver disease: a condition caused by modern day lifestyle

Non-alcoholic fatty liver disease (NAFLD) refers to the build-up of fat (steatosis) in the liver that occurs in the setting of obesity and/or diabetes. Specifically, other causes such as alcohol excess or drugs or genetic conditions need

GM herbicide-tolerant crops, weedkillers, and resistant weeds: overview and interplay

Since their beginnings, GM crops have been a subject of debate in spite of their quick adoption by farmers in several countries. In the last 20 years GM herbicide-tolerant (HT) crops, generally glyphosate-tolerant crops, have been the

Antibiotic resistance re-visited

With the introduction of antibiotics at the beginning of the 20th century, the threat of bacterial infections was thought to over. Today, antibiotics are still used as the first, if not only, line of defense against bacterial