Tag Archives: ribosome
Unraveling multiple checkpoints for accurate selection of initiator tRNA on ribosomes for translation initiation
Ribosomes comprise a large (50S) and a small (30S) subunits. To begin (initiate) protein synthesis, the two subunits associate on an mRNA (70S). Organisms possess two classes of tRNAs, the initiators (i-tRNA) and the elongators. The i-tRNA
Could there have been a form of “life” that integrated genetic information, protein translation, and the molecular machinery necessary to replicate itself before the first cells? Might such an entity still exist within our cells as a
Protein synthesis is an energetically costly cellular process, in part due to the metabolic requirements of ribosome assembly and gene-specific messenger RNA (mRNA) production. Consequently, biosynthetic flux through the protein translation pathway is tightly regulated while translational
In the cell DNA is present in the duplex form and many messenger RNAs (mRNAs) can form duplex structures. To access the genetic information (represented by nucleotides or codons) on the single-stranded (ss) nucleic acids (NA) by
Food safety issues are always around us for food-borne pathogen and spoilage bacteria exist in many kinds of food. Chemical preservatives are added to prevent food spoilage, however, most of them are cancerogen and unsafe for us.