Tag Archives: stem cells
Understanding cardiac arrhythmias using an embryonic stem cell model
Embryonic stem cells are pluripotent and have the capability to differentiate into almost all cell types of the body. Thus, they offer great potential for regenerative medicine such as cell-based therapies and basic research purposes including disease
Recurrent ontogenesis
Flowering plants arose during the Cretaceous, and up to date they count around 235,000 species, representing the largest and most diverse group within the plant kingdom. One of the foundation of their success relies upon the production
Pancreatic cancer stem cells: fatty acid synthesis and mevalonate pathways are implicated in their survival
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high metastatic potential. The disease is the fourth leading cause of cancer-related deaths in the USA, and is projected to be the second one by 2030, due
The use of bone marrow-derived mononuclear cells ameliorates airway inflammation in horses with recurrent airway obstruction
Horses stabled indoors live in a pro-allergenic environment and are exposed to molds, mites, and bacterial endotoxins from hay and bedding. This exposure exacerbates recurrent airway obstruction (RAO), an asthma-like disease. Affected horses suffer from recurrence of
A predictive approach for nanotoxicity assessment using stem cells
Advance in nanotechnology has prompted the science world to recognize the risk and potential health effects associated with the growing as well as incongruous use of nanoparticles. The current methods often employ a predictive toxicology approach that
Cellular barcoding: giving names to every stem cell
There are many different cell types in the blood, all of different functions and shapes. All these cells are made by the stem cells by a process of lineage commitment and differentiation. How can we monitor this
Jellyfish meets algae – two marine materials enabling adult stem cells to heal cartilage defects
The regeneration of cartilage in humans is a big challenge, since cartilage tissue cannot regenerate from itself after an injury. Therefore, the application of tissue engineering strategies is very promising for the healing of cartilage defects. Tissue
NucleoCounter® NC-200™ – Automated Cell Counter
The NucleoCounter® NC-200™ is a high precision automated cell counter utilizing state-of-the-art image cytometry. With user adaptable protocols and specialized assays for counting a wide range of mammalian cells, including adipose-derived stem cells, T cells, aggregated cells
Building and rebuilding gastric epithelium: Trop2 as a common denominator
In mammals, the stomach is lined by a contiguous layer of cells called epithelium, further organized into units called glands. Gastric glands are divided into two areas: corpus and antrum, according to their specific function depending on
Insulin analogue with reduced weight gain effect in diabetic patients: detemir
Diabetes mellitus is a progressive condition in which the glycated hemoglobin level (i.e. marker of average blood glucose levels) rises inexorably over time. Strict glucose control in patients with type 1 or type 2 diabetes mellitus reduces
A New therapy for healing nonunion fractures in patients using self-bone marrow derived mesenchymal
Sometimes a broken bone fail to heal (“nonunion”) and it is necessary to induce the formation of new bone tissue to connect the broken pieces. Investigators from the Instituto Venezolano de Investigaciones Cientificas (IVIC) and orthopedic surgeons
Embryonic stem cells go against aging
The dream of regenerative medicine is now becoming true by the usage of versatile stem cells that are capable of differentiating into all types of cells in the body. This capability is called ‘pluripotency’ and there are
Animal-free platforms for the efficient and accurate prediction of kidney toxicity in humans
Tens of thousands of chemicals are used in food, cosmetics and consumer products. In addition, humans are exposed to drugs and environmental toxicants. Safety testing based on animals is too slow and too costly for screening the
Gliomas and the microenvironment
Recently, the term “microenvironment” has been introduced to indicate all the cell types and molecular signaling that in tumors regulates transformation, growth, invasion, therapeutic resistance and defense from host immunity. In malignant gliomas, i.e., glioblastoma, the most
“Good kids in bad neighborhoods” – the role of bone marrow microenvironment in the development of acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common and aggressive blood cancer in adults and is associated with a high rate of mortality due to cancer therapy resistance and disease relapse. AML is characterized by severe deficiency
Cortical bone: a ground-breaking source for multipotent stem cells
Multipotent stromal cells also known as mesenchymal stem cells (MSCs) are a family of cells derived from the mesodermal germ layer, distinguished by their ability to replicate themselves and differentiate, or change morph into different types of
