Tag Archives: T cell
The allergies go marching on: the atopic march and the temporal relationship of allergic diseases
Atopic/allergic family of diseases affects >20% of the global population and encompasses allergic asthma, hay fever, food allergy, atopic dermatitis, and allergic rhinitis. Frequently, individuals with an allergic condition develop another allergic disease. The atopic march theory
Defects in mismatch repair increase cancer risk and influence treatment selection
Microsatellites are formed by 1-6 nucleotide base pairs that are repeated in direct order 5-50 times. Repetitive DNA including microsatellites are mainly present in non-coding DNA regions that occupy more than 97% of the nuclear DNA. They
Vaccine design in the OMICs Era
A retrospection into the field of vaccinology reveals the triumph of medical science over infectious diseases that were once a death sentence. Research on vaccines has come a long way since 1796 when Edward Jenner used a
New antimicrobial strategies against multidrug-resistant pathogens
Due to current antibiotic resistance worldwide, there is an urgent need to find new alternative antibacterial approaches capable of dealing with multidrug-resistant pathogens. In fact, the World Health Organization has recently announced the increasing high levels of
Antigen-expressing regulatory T cells can protect against allergic reactions
Our immune systems are designed to protect us from dangerous foreign invaders, like viruses, bacteria or parasites. However, sometimes we respond to usually harmless foreign materials, e.g. pollens or food, the results of which can be mild
Stable housing can significantly improve health outcomes in women living with HIV
Unstable housing, including homelessness, is a key socioeconomic determinant of poor health outcomes and premature death in the United States. Housing-insecure individuals are more likely to delay seeking medical care due to costs, lack of health insurance,
Does intestinal inflammation impact the lung response to bacterial endotoxin?
Lung inflammation leading to airway hyperresponsiveness causes illnesses for more than ten percent of the population in USA. Recent research had indicated that patients with inflammatory bowel disease have higher incidence of airway hyperresponsiveness compared to the
A new immune signature in people with Polycythemia vera: a modulator of disease progress?
Polycythemia Vera (PV) is a disease in which your body makes too many red blood cells (RBC), whose main function is to transport oxygen from the lungs to all parts of your body. The many circulating RBC
How cancer cells communicate with nervous and immune systems
In the last decade, studies have shown that cancer cells can influence their environment and bi-directionally communicate with other systems including immune and nervous systems. The neuro-immune interaction is a key player in influencing cancer development and
Can we treat cancer by targeting Treg subset without causing autoimmune disease?
The regulatory T cells (Tregs), are a type of CD4+ T cells that suppress the potentially adverse effect of the immune system and prevent autoimmune disease. Although they play a central role in maintaining self-tolerance, Tregs also
A powerful tool for the study of CD4 T cells in malaria
Although aimed at controlling invading pathogens, immune responses can sometimes be harmful to the host. Responses against the blood stage of malaria are an example of this: while B cells are activated and produce useful antibodies that
Curing glioblastoma with oncolytic virus and immune checkpoint blockade
Cancer immunotherapy utilizes the patient’s immune system to recognize and/or destroy tumors. The immune system has both positive activator/effector and negative inhibitory functions. Immune checkpoints are one such inhibitory function that can be overcome by immune checkpoint
Inner myeloid gene network as a nexus of hematopoiesis and infection
The immunological system is equipped with efficient and tunable mechanisms to remove immediately pathogens from our body. Invasion of microbes in the blood is an emergency state, because they can trigger inflammatory responses, leading to sepsis. Therefore,
The T cell IFT20 interactome: new insights into immune synapse assembly regulation by the IFT system
T lymphocytes are key cellular components of the immune system that are essential for the elimination of viral, bacterial and parasitic infections as well as of malignant cells. T cell activation is initiated following recognition of pathogen-
The role of monocytes in ANCA-associated vasculitides
The anti – neutrophil cytoplasm antibody (ANCA) – associated vasculitides (AAV) include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). These rare systemic autoimmune diseases affect small and medium – sized blood vessels, and are characterized by necrotizing vasculitis,
The gods of human T cell development
T cells are the component of the immune system required for recognizing and targeting pathogens and tumor cells. Because each T cell recognizes a different pathogen, the challenge of T cell development is to create a pool
Identification of a new T cell regulator
T-cell receptor (TCR) signaling is mediated by the activation of protein-tyrosine kinases such as p56lck and ZAP-70. In mature T-cells, CD4 and CD8 molecules bind to p56lck which then phosphorylates the intracellular immune-receptor tyrosine-based activation motifs (ITAM)
Oocyte activation and latent HIV-1 reactivation: AMPK links the creation of all human life and the potential eradication of HIV-1
In an active area of research known as HIV-1 cure research, the purposeful reactivation of latent/dormant HIV-1 in memory T cells, which induces death of the infected cell or alerts the immune system to the presence of
Hyper IgM syndrome in North America: a rare disease of a critical step in the immune response pathway
Hyper IgM (HIGM) syndromes are a group of rare genetic disorders leading to ineffective immune responses. People with this immune defect are usually diagnosed in early childhood due to frequent infections. Most of these are common but
BRAF inhibitor and interferon alpha combination for melanoma treatment
In recent years approval has been granted to many therapeutic agents for the treatment of patients with metastatic melanoma. They include small molecule inhibitors, such as the selective inhibitors of the mutant BRAF (BRAF-I) or of MEK (MEK-I), and
