Tag Archives: T-cells

The T cell IFT20 interactome: new insights into immune synapse assembly regulation by the IFT system

T lymphocytes are key cellular components of the immune system that are essential for the elimination of viral, bacterial and parasitic infections as well as of malignant cells. T cell activation is initiated following recognition of pathogen-

Activation: a double-edged sword for Treg

Regulatory T cells (Tregs) are a specialized subset of T cells. As the name suggests, they play a role in controlling and regulating other immune cells. Tregs, characterized by the expression of the forkhead/winged-helix transcription factor Foxp3,

Anti-CD20 treatment shows changes not only in B-lymphocytes but also in T-subpopulations

In renal pathology, Rituximab has been proven to be useful in the treatment of some primary glomerulopathies, vasculitis with renal involvement, severe lupus with kidney disease, and especially in renal transplantation, where it is applied during the

Epstein Barr Virus (EBV) infection empowers B lymphocytes for autoimmunity

The human body is under constant threat of foreign invaders (bacteria, viruses, parasites) that can cause infectious diseases. The reason why this often does not occur is the immune system, a complex collection of molecules and cells

Gut microbiota: A potential trigger of rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder characterized by synovitis in multiple joints and systemic comorbidities. Both genetic and environmental agents are thought to be the risk factors for arthritis. Recent studies have suggested that

The oncolytic virus ∆PK has multi-modal anti-tumor activity

Oncolytic viruses (OVs) are an emerging cancer therapeutic based on tumor cell lysis by replicating virus and the resulting release of cellular proteins [viz. tumor-associated antigens (TAAs)], which modulate tumor immunogenic cell death (ICD). OVs have a

Lymphocytes T and Treg as prognostic factors of newly diagnosed DLBCL patients

Diffuse large B-cell lymphoma (DLBCL) is an aggressive and most common form of non-Hodgkin lymphoma. The mechanism of DLBCL pathogenesis is not fully understood. Malignant B-cells responsible for lymphoma formation are believed to arise from different stages

Microfluidic tumor models help pre-clinical screening of T cell cancer immunotherapies

Cancer immunotherapy draws upon the patient’s own immune system to recognize and fight the disease. One form of cancer immunotherapy is known as adoptive T cell therapy (ACT) consisting of isolation, genetic manipulation and reinfusion into the

Zinc – A beneficial player in autoimmune diseases

Essential trace elements, especially zinc, are indispensable for a proper immune function. Zinc deficiency or excess causes severe impairment of the immune response. So far, an increased susceptibility to infections, increased number of transplant rejections, development of

Is our immune system mistaking tumours for foetuses?

Tumours are abnormal growths of tissue where cells produced by the body get out of control and divide at a rapid and unregulated pace. And – when you think about it – embryos too are masses of

Polyfunctional T cells induced potent anti-tumor efficacy

Adoptive T cell therapy is a form of cancer immunotherapy using T cells to target cancer cells.  In adoptive T cell therapy, white blood cells are collected from cancer patients, T cells (CD4+ and CD8+ cells) within

Another prince awakened Sleeping Beauty?

Tumor suppressor genes are one of the body’s defenses against uncontrolled growth of tumor cells. When these genes are ‘silenced,’ or prevented from doing their work, the abnormal cells grow unchecked, usually with fatal consequences to the

CD164 helps physicians to diagnose and treat cancer in Sézary Syndrome

Cutaneous T-cell lymphomas (CTCL) represent malignancies of the T-lymphocytes that go to or reside in the skin. Roughly 50% of all CTCL cases are Sézary Syndrome and Mycosis Fungoides. The typical external manifestation of the disease is

Focusing on non-tumor-derived factors for leukemia therapy

Approximately 10-20 million people worldwide are estimated to be infected with human T-cell leukemia virus type I (HTLV-I), and 1-3% of HTLV-I-infected individuals develop a cancer of CD4+ T lymphocytes in the blood each year.  The retrovirus-associated

B cells to the rescue: regulatory B cells are a promising therapeutic target for autoimmune disease

Immune cells are indispensable for protecting us from microbial infections. They recognize specific patterns on microbes to mount robust cellular and molecular immune responses for the clearance of pathogens. Intriguingly, development and function of these cells is

How the immune system is regulated by small RNAs called microRNAs to prevent self-attacks leading to autoimmunity

The ability to properly engage the different arms of the immune response is essential for protection from pathogens but also for preventing autoimmune reactions against normal tissue. Central to autoimmune prevention are a class of white blood