Tag Archives: toxicity

Toxicity of graphene in lung alveolar epithelial cells

Graphene is a fascinating nanomaterial that has garnered significant scientific interest because of its unique properties such as superior thermal and electrical conductivity, high mechanical strength and unique optical properties. Due to this reason graphene has numerous

Product of red grapes protects kidney from anticancer toxicity by increasing its extruding protein

Cancer chemotherapy is a double-edged tool. At one side, increasing anticancer dose may cure cancer but can cause severe toxic effects to vital organs. At the other side, decreasing the dose can protect vital organs from the

Cultured macrophages help predict lung toxicity of inhaled nanoparticles

Many small particles of industrial or occupational origin are believed to infer an inflammatory or otherwise toxic potential to human health upon inhalation. Knowledge on this issue is especially important for the very small nanoparticles, which measure

Animal-free platforms for the efficient and accurate prediction of kidney toxicity in humans

Tens of thousands of chemicals are used in food, cosmetics and consumer products. In addition, humans are exposed to drugs and environmental toxicants. Safety testing based on animals is too slow and too costly for screening the

Side effects of radiation therapy: Why me?

Most lung cancers are treated with radiation therapy, often in high doses.  Although these treatments are absolutely required to prolong life (by killing the tumor or slowing its growth), radiation treatment can have negative side effects that

A cysteine residue is a key commander of SOD1-related neuronal toxicity in ALS

Amyotrophic lateral sclerosis (ALS; a.k.a. Lou Gehrig’s disease) is a life-threatening disease of motor neurons that gradually affects muscle strength of the whole body. The disease occurs familially in some cases, and 25 to 30% of the

Compounds earlier known as neurotransmitters are met and function in every living organism

Historically, the neurotransmitters function were analyzed only in animals with nervous system, and their initial role was associated mainly with the transmission of nerve (electrical) impulses. In the last decade of the 20 century, new views on

Lipids are major players in Alzheimer’s disease

Alzheimer’s disease is the most common neurodegenerative disorder affecting over 36 million people worldwide. Alzheimer’s patients suffer from dementia and memory loss and go through a progressive, irreversible and eventually fatal loss of cognitive functions. When Alois

A novel approach to characterizing the type of three-factorial combined toxicity

We carried out an experiment in which outbred white rats were subjected to repeated injections with water solutions of either one of the toxics (Mn, Ni or Cr salts) in doses isoeffective in respect to the lethal