Tag Archives: virus

The autonomous glycosylation of Giant, but sweet, viruses

The most of proteins carry sugars on them, which significantly modify their properties such as biological activity, solubility and resistance to protein-degrading enzymes. The sugars on proteins drive several fundamental biological mechanisms, such as hormones response, immune

Making a good drug against a bad virus better

Recent advances in the treatment of chronic Hepatitis C virus (HCV) have led to a number of treatment options using only pills taken once-a-day that can lead to the elimination of the virus – a cure. Using

In silico prediction of ebolavirus RNA polymerase inhibition

A virus at work: Let us assume that you are a virus that just infected a cell (the HOST CELL) of an individual (the PATIENT). What is your vicious objective? You want to make copies of yourself

The origin of the HIV-1 epidemic

The epidemic of human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS, is one of the world’s major public health problems, with around 37 million people currently infected with this virus. The HIV-1 epidemic originated

HCV controls the export machinery of infected cells to increase its own spread

When a virus infects a cell it changes a lot of the cells functions and behavior to its own benefit. The virus reproduces inside the cell and forces it to release many new virus particles which can

Cerium fluoride nanoparticles protect cells against oxidative stress

Nano-biomaterials engineering is one of today’s most promising areas of materials science. In very recent years, nanocrystalline cerium oxide (nanoceria) has been shown to possess enormous biological activity, which originates from its ability to scavenge the reactive

Bibliometric analysis of scientific output on influenza in Mexico, 2000-2012

During the spring of 2009, H1N1 influenza became the first pandemic of the 21st century. In the last years, bibliometrics studies have proliferated seeking to provide data on world research. There are no bibliometric studies in Mexico

Ultrasensitive detection of influenza viruses by glycan biosensors

These days there is a considerable interest to develop devices, which are able to detect various diseases at early-stage with a high speed and reliability to enhance efficiency of subsequent disease treatment. The first step towards this goal

Silencing suppressor proteins shape virus-host co-evolution

Plant viruses are amongst the most important pathogens causing huge economic losses worldwide by reducing crop quality and quantity. A better understanding of the viral infection processes and plant defense strategies is important for crop improvement. During

A novel reovirus mutant: toward the next generation of viruses for cancer treatment?

In the last decade or so, it has been realized that viruses are not only foes to fight, but possible therapeutics against diseases such as cancer. Most of these so-called oncolytic viruses are engineered to acquire desirable

Counteracting a host factor allows adenovirus infection to progress to new virus production

Viruses use the cells of another organism to reproduce and spread. Although very variable in size, the genetic material of a virus is usually tiny in comparison to that of its host and so cannot specify very

Is the post-polio syndrome due to chronic poliovirus infection?

Over the years, poliomyelitis survivors may experience e progressive decline of physical strength accompanied by intolerance to cold, chronic pain and other disabilities. This condition, termed post-polio syndrome (PPS), may lead to the incapacity of living an

Virus containing mealybug DNA kills mealybug

One way of self-regulating protein synthesis by animals is suppression of the relevant messenger RNA (mRNA); molecules that translate into amino acids and act as building blocks for protein. The mechanism, called RNA interference (RNAi), works by

Imaging of viruses with the help of surface plasmons

For a long time biosensors based on the surface plasmon resonance (SPR) phenomenon were not considered as effective tools to detect and visualize the binding of individual nano-scale objects to the functionalized sensor surface. However, innovative studies

Epstein–Barr virus in peripheral blood predicts response to rituximab therapy in rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic inflammation of the joints that may cause permanent cartilage and bone damage. The cause of RA is unknown. It is, however, believed that a combination of genes

A new general principle of virology

Shin et al describe for the first time a novel strategy used by persistent viruses to temporally regulate expression of the structural proteins that make up their virus particles. The viruses that infect humans and other mammals