The most effective system to weight lost
People who suffer from morbid obesity are at high risk for many diseases, atherogenic dyslipidemia, elevated blood pressure, type 2 diabetes, thromboembolism, hepatic steatosis, proinflammatory state, etc. Metabolic syndrome is characterized by the clustering of some, or all, of these metabolic abnormalities in the presence of underlying insulin resistance with a strong association with diabetes and cardiovascular disease morbidity and mortality.
Bariatric surgery with or without diet change has become one of the most effective treatments for obesity. The objective of our study was to observe the effects of vertical sleeve gastrectomy (VSG) and diet change in Sprague-Dawley rats on both body and tissue weights.
Comparing the rats fed with Standard Chow Diet (SCD) (C group) with those fed with High-Fat Diet (HFD) (DIO group) after 8 weeks a significant increase in weight was observed in the latter. At that moment an SVG was practiced, and for four weeks, half of the group DIO was feeding with HFD while the other half changed to SCD (DIO+C group). The major weight loss was observed in the DIO+C group, during the 4 weeks after surgery. Adipose tissues (epidydimal white and perirenal white adipose tissue) in the DIO+C group were drastically reduced and had a weight similar to those in the C group.
VSG and the diet-change combination led to a greater weight loss, which was maintained during the 4 weeks post-surgery, leading to a normalization of body weight. VSG and diet change also affected most of the tissues, not only adipose, showing a global change in whole-body composition.
Joana Rossell 1, Marta González 2, Núria Mestres 2, Eva Pardina 1, David Ricart-Jané 1, Juan Antonio Baena-Fustegueras 2, Julia Peinado-Onsurbe 1
1Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona
2Unitat de Cirurgia, Hospital Universitari Arnau de Vilanova, Universitat de Lleida, Lleida, Spain
Funding: This work was supported by Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III (ISCIII) (PI11/01159, PI15/00190 and PI15/00332 to JAB-F and JP-O), were co-financed by European Union Funds, Fondo Europeo de Desarrollo Regional (FEDER) “Una manera de hacer Europa”.
Diet Change After Sleeve Gastrectomy Is More Effective for Weight Loss Than Surgery Only.
Rossell J, González M, Mestres N, Pardina E, Ricart-Jané D, Peinado-Onsurbe J, Baena-Fustegueras JA
Obes Surg. 2017 Oct