Treatment holidays for patients with metastatic kidney cancer
Targeted therapy is the standard treatment of patients with metastatic cancer of the kidney. The best current therapies target the tumour vasculature thereby blocking the access of the tumour to nutrients and limiting possibility of spreading to distant parts of the body.
Kidney cancer that has already spread and formed metastases is considered incurable. However, a minor part of patients will have excellent response to targeted therapies and will experience complete response – disappearance of all tumour lesions. We believe that this does not, unfortunately, mean cure because the tumour will come back (relapse) in almost all of them after certain time. Nevertheless, interruption of treatment may be possible and is often done in these patients to enable them a period of rest from side effects of therapy.
According to this registry-based analysis, patients with metastatic renal cancer with no signs of disease (complete response) after treatment with targeted agents experience excellent long-term survival even if the treatment does not continue beyond the date of complete response.
Of 2803 patients with data on targeted therapy in our national registry, 100 patients achieved complete response. These patients experienced excellent survival and 80% were still alive 5 years after the start of therapy. This is much better than average patients treated for metastatic kidney cancer. Importantly, if the treatment was discontinued while the patients were still in complete response, the survival was not adversely affected. This is a retrospective study with some limitations but the results are encouraging for those patients who have complete response and want to spend some time off treatment, and their physicians.
Department of Oncology, First Faculty of Medicine
Charles University and Thomayer Hospital
Prague, Czech Republic
Outcomes for Patients with Metastatic Renal Cell Carcinoma Achieving a Complete Response on Targeted Therapy: A Registry-based Analysis.
Buchler T, Bortlicek Z, Poprach A, Pavlik T, Veskrnova V, Honzirkova M, Zemanova M, Fiala O, Kubackova K, Slaby O, Svoboda M, Vyzula R, Dusek L, Melichar B; Czech Renal Cancer Cooperative Group.
Eur Urol. 2015 Dec 30
|Melanoma is controlling metastasis of melanoma – fact… The title is provocative, because most will most ask: but who other than mm can control the metastasis of melanoma? But let's get on the path of facts and procedures…|
|Rare breast tumor cells in lymph nodes are enough to impact… Early detection of breast cancer leads to essential cure of the vast majority of patients, through surgery and associated therapies. However, severe outcomes can be observed even among disease cases…|
|FDG-PET/CT is accurate in diagnosing breast cancer… A woman with a substantial risk of breast cancer recurrence experiences worry and anxiety, and a correct diagnosis is relevant in order to make well-founded decision on treatment strategy. It…|
|Heart disease in cancer patients (onco-cardiology /… In the United States, heart disease and cancer have been the 2 leading causes of death from 1935 through 2013. In 2010, both diseases accounted for almost half of all…|
|Who is a cancer survivor? A brief overview of this… Chiara Marzorati, Foundations of the Life Sciences Bioethics and Cognitive Sciences, European School of Molecular Medicine (SEMM), European Institute of Oncology, Via Adamello 16, 20139, Milan, Italy. Gabriella Pravettoni, Department…|
|Renal cell carcinoma: can we identify patients with advanced Kidney cancer is among the 10 most common cancers in both men and women with approximately 61,560 new cases and 14,080 deaths from this disease expected in 2015. Clear cell…|