Newly emerging drugs of abuse: A cat-and-mouse game
Recreational drug abuse and the resultant overdose have been a serious public health threat in the U.S. and the world. While traditional drugs of abuse remain popular, recreational use of newer synthetic drugs has continued to increase.
The allergies go marching on: the atopic march and the temporal relationship of allergic diseases
Atopic/allergic family of diseases affects >20% of the global population and encompasses allergic asthma, hay fever, food allergy, atopic dermatitis, and allergic rhinitis. Frequently, individuals with an allergic condition develop another allergic disease. The atopic march theory
The root is an ideal system to study magnetobiology in plants
Given that the origin and evolution of life had occurred in the presence of the geomagnetic field (GMF), it is possible that GMF information has been exploited by organisms as an important natural resource to tackle the
Short hydrogen bonds in proteins and their quantum mechanical nature
The assembly of linear polypeptide chains into functional three-dimensional protein architectures involves a unique force called hydrogen bonding. A typical hydrogen bond forms when the donor and acceptor groups approach each other with a nearly linear geometry
Modulation of intracellular dopamine signaling by aripiprazole may cause malocclusion as an extrapyramidal symptom
Aripiprazole, a dopamine partial agonist, is one of the most widely prescribed atypical antipsychotics and its use in children and adolescents has become common. However, due to its favorable side effect profile, its potential for inducing extrapyramidal
Role of dopamine in cortico-basal ganglia loop in psychosis
Dopamine plays a major role in the formation of acute psychosis, as indicated by the dopamine hypothesis of schizophrenia. The relationship between acute psychosis and the dopamine system provides insight into the effects of dopamine on brain
Defects in mismatch repair increase cancer risk and influence treatment selection
Microsatellites are formed by 1-6 nucleotide base pairs that are repeated in direct order 5-50 times. Repetitive DNA including microsatellites are mainly present in non-coding DNA regions that occupy more than 97% of the nuclear DNA. They
Is milk and meat from the offspring of a bull genome edited to have no horns safe to eat?
Horns on cattle are an animal welfare and human safety concern, but most high producing dairy breeds grow horns. Introducing the polled (hornless) trait into the dairy population by crossbreeding would also introduce non-productive traits by linkage
Postponed protonation under competitive conditions in rhodium catalyzed domino reactions
The readily available α,β-unsaturated compound (Michael acceptor) serves as one of the most important building blocks in synthetic chemistry, which is widely used in conjugate addition reaction. The characteristic of conjugate addition reaction is that it is
Deep Molecular Profiling to understand the biology of Alzheimer disease
Alzheimer disease (AD) is a complex, polygenic disease with genetic, cellular, pathologic, and clinical heterogeneity. Advances in high-throughput sequencing and omics technologies have accelerated the drive toward personalized medicine. Human bio-specimens using these high-throughput platforms have emerged
Cosmology in a cell: Defect annihilation in liquid crystals
Topological defects are configurations of the order parameter which cannot be transformed continuously into a uniform state. They have been observed in various areas of physics, such as alloys, semiconductors, particle physics and cosmology. Due to the
Ultralong room-temperature phosphorescence of a solid-state supramolecule
Glows in the dark after removing energy input, named room-temperature phosphorescence (RTP), has got enormous attention because of its various application in biological imaging, light-emitting devices, information storage and encryption, and so on. However, achieving ultralong RTP
Essential fatty acids in the vegan/total vegetarian diet
People choose vegetarian/vegan diets and for many reasons, however, these diets require careful dietary planning. The essential polyunsaturated n-6 (omega-6) and n-3 (omega-3) fatty acids are required for synthesis of inflammatory compounds, cell membranes, skin, brain and
WRGSD: improving reliability and efficiency for coastal monitoring network
Water-quality response grid-based sampling design (WRGSD) using optimization and multi-factors assessment can reliably detect a variety of the impact of human activities. The sampling design are optimized by clustering and dividing the water quality response grid to
Cs adsorption by Mn‒Fe-based Prussian blue analogs formed in agarose gel
The Fukushima nuclear accident triggered a massive release of radioactive cesium (Cs) isotopes into the environment and generated a large amount of contaminated water. Because Cs isotopes pose serious threats to the environment (particularly the aquatic environment),
Inner peace and faith: the impact of spiritual well-being on anxiety protection in healthcare workers
Anxiety is considered the most common mental disorder. The anxiety symptoms (AS) are usually associated with several physical and mental illnesses. Previous investigations have shown that AS are exceptionally high in healthcare workers (HCWs). Furthermore, some studies
Silkworms turning your shirt into a cell phone battery
Feeding Bombyx mori larvae with nanostructured materials such as CNTs, graphene, TiO2 and other metal oxides have been investigated in recent reports. The feeding process proved that Bombyx mori larvae can intake nanostructured materials, which affect the
Actinobacteria from Algerian ecosystems as a rich source of bioactive molecules promising for new potential drugs
Secondary metabolites are molecules not essential for the growth and development of microorganism, mainly having a defence role. They have shown a great potential for the discovery of drugs and their study still draws attention to the
Low phosphate after modern intravenous iron? Fibroblast growth factor 23 may be the key!
Iron is an essential substance with a number of roles in the body. Anaemia caused by low iron (iron deficiency anaemia) can worsen disease outcomes and reduce the quality of people’s lives. Iron deficiency anaemia can be
The SETOC: Visualizing carcinogenesis through a different lens
The Systemic-Evolutionary Theory of the Origin of Cancer (SETOC) is a recently proposed theory based on two fundamental principles: (i) Margulian evolution as a process of cooperation and endosymbiosis and (ii) Systemic cell biology understood as the
