Mitochondrial Complex I activity signals antioxidant response through ERK5
The vast majority of eukaryotic cells perform oxidative phosphorylation (OXPHOS), which uses the energy released by the mitochondrial oxidation of certain metabolites, i.e. glucose, to produce adenosine triphosphate (ATP). OXPHOS is highly efficient in energy production but
Adult-onset biotinidase deficiency
Biotinidase is the enzyme that recycles the water-soluble vitamin, biotin, which is the coenzyme for four carboxylases that are involved in gluconeogenesis, fatty acid synthesis, and in the catabolism of several branch-chain amino acids. Biotinidase deficiency (BD)
Immunogenicity and safety of the new inactivated quadrivalent influenza vaccine Vaxigrip Tetra
Influenza represents an acute viral respiratory disease caused by RNA-enveloped viruses. They belong to the Orthomyxoviridae family which comprises five genera, but only two (influenza A and B viruses) are of medical relevance in humans. Even though
In defense of Lady Windermere Syndrome
The eponym, Lady Windermere Syndrome (LWS), designates a disorder, exclusive to older women who are free of a predisposing lung disorder, caused by Mycobacterium avium-intracellulare and characterized by disease limited to the lingula and/or the middle lobe
The voltage-gated potassium channel, Kv1.3, at the crossroads of glial functions in glioma
Glioblastoma multiforme (GBM) is one of the most lethal cancers in adult humans, with a frequency of 6:100.000 people. Despite the current three-modality therapy, which includes surgery, radiation and chemotherapy, the clinical outcome of GBM patients remains
Genome editing in non-dividing cells: new strategies are required
Although rare individually, genetic disorders collectively constitute a common health problem. As the cause of these diseases is a defective gene, gene therapy would be able to resolve all of these disorders. The most recent method of
We’re all afraid to die, even the young and faithful
Fears of death and dying, sometimes called “death anxiety,” “thanatophobia,” or “mortality salience,” have long been studied in psychology and other fields. The topic is important and interesting because prior studies have shown death anxiety to be
Honey as a tool for tissue engineering
Honey has a long and fascinating history. In fact, since Biblical times and before, honey has been utilized by humankind for its beneficial health effects. The ancient Egyptians, Assyrians, Chinese, Greeks and Romans utilized honey in the
Vagal stimulation for treating syncope by cardioneuroablation without pacemaker implantation
The heart has a dense innervation that permanently regulates its activity. It is the autonomic nervous system, constituted by two antagonistic divisions, the parasympathetic and the sympathetic. The latter stimulates the heart, increasing cardiac rate and contraction
Molecular defense adopted by sea urchin embryos to cope with Nickel
Nickel (Ni) is a natural constituent of the Earth’s crust and, together with its compounds, it is used in many industrial and commercial applications. At very low doses, Ni carries out many physiological roles in biochemical processes
High seroprevalence for Crimean-Congo haemorrhagic fever virus in ruminants in the absence of reported human cases
Crimean-Congo haemorrhagic fever (CCHF) is a severe tick-borne zoonotic disease in humans caused by CCHF virus. Close contact with viraemic livestock was shown as one of the main causes of the infection. Detection of CCHF virus specific
Efficient catalyst-free removal technique of benzene in air using a vacuum ultraviolet excimer lamp
Benzene (C6H6) is a typical VOC (volatile organic compound) pollutant which is widely detected in the atmosphere of both indoor and industrial areas. Especially in indoor environment, it would make a great influence on human health for
Vitamin D deficiency is a sign of poor health in chronic obstructive pulmonary disease
Vitamin D is an important hormone in growth and bone metabolism. Vitamin D deficiency is highly prevalent worldwide and causes growth retardation and rickets in children and osteomalacia in adults. However, the role of vitamin D deficiency
Camphor biodegradation by Pseudomonas putida plays a key role in carbon cycling in the biosphere
The key role of microorganisms in promoting carbon cycling in the biosphere is well illustrated by the biodegradation of the natural plant terpenoid camphor by Pseudomonas putida ATCC 17453. Research has established that several different monooxygenases (cytochromeP450
Routine imaging in patients with follicular lymphoma in remission
B-cell lymphomas are a heterogeneous group of malignancies originating from B lymphocytes. Modern day chemotherapy is effective in inducing disease remission in a large percentage of patients for most of the subtypes. Some of these subtypes, the
Authentication of Egyptian blossom honeys
Twenty-two blossom honey samples (clover and citrus honeys) were collected from the greater Cairo area during harvesting year 2014-2015. The main purpose of the present study was to characterize the aforementioned honey types and to investigate whether
Functional significance of interhelical interactions between aspartic acid and cysteine residues in microbial rhodopsin
Microbial rhodopsins are photoreceptive seven-transmembrane proteins that contain all-trans retinal as a chromophore. Upon photon absorption, these proteins undergo a cycling photoreaction, where first the initial trans-to-cis isomerization of retinal induced by illumination leads to the formation
Treatment of experimental eye inflammation with a single subconjunctival injection of liposomal steroid
Non-infectious anterior uveitis is an inflammatory condition in the front of the eye that can potentially lead to blindness. The current gold standard for treatment is with steroid eyedrops. However, this treatment has several disadvantages. Very little
Simplified molecular diagnostics on a chip for point-of-care diagnostics
Analysis of blood, urine, and saliva often serves as the primary basis of diagnosis and treatment. Clinical specimens contain signature molecules (‘markers’) such as proteins and nucleic acids that are indicators of infection, cancer, and other diseases,
Do patients return to sport activities after total hip replacement?
Total hip replacement (THR) is a successful procedure to treat end-stage hip osteoarthritis. The procedure is increasingly performed in adults of working age, who often wish to return to highly demanding activities, including a return to sports
