The past shapes the future: How socio-environmental conditions affect growth and sexual dimorphism
Sexual size dimorphism (SSD) is the difference in body size between males and females of the same species, which is common among mammals with males typically being larger. Sexual selection is thought to be the main cause
What drives the syneresis of lacto-fermented sodium caseinate?
Fermented dairy products have a great nutritional value and health beneficial effect on host gut micro-biome, due to their probiotics bacteria. Syneresis is considered as a major defect in these acid-induced gels products, which is a major
Intense light boosts the circadian function of cardiac vessels which protects from heart attacks
Humans are daily exposed to intense light in the form of sunlight which is crucial for the circadian rhythms in our bodies to properly function. This is important as circadian rhythms regulate all physiological processes in the
Matching between adult neurons: feel abandoned? Just call on me
Plasticity in the central nervous system allows the adaptation of neural circuits to new circumstances, such as the recovery after brain injury. The mechanisms of neural plasticity include, among others, the formation of new synapses. An example
Ultrasound generate electricity inside the body
Implantable medical devices (IMDs) are highly beneficial to patient health. Concerning rapidly evolving technologies for IMDs, sustainable and reliable powering methods for IMDs is truly essential. They are generally relying on primary batteries, which are subject to
A molecular passport authorizes intracellular travel for a potential cancer therapy antibody
Whether from external environmental factors or spontaneous intracellular processes, the DNA in our cells is under constant bombardment by DNA damage. Because unrepaired DNA damage can cause cell death, our cells have evolved vital mechanisms to repair
What treatment is really medically and economically desirable for chronic hepatitis C patients with treatment failure after 8-week glecaprevir/pibrentasvir in Japan?
Currently, direct-acting agent (DAA) therapies have high efficacy and safety and are the main strategy to eliminate hepatitis C virus (HCV) worldwide. Some DAA therapies are also effective for HCV-infected patients who have experienced prior DAA failure.
Botryococcus braunii – A potential source of high value chemicals
High value biochemicals, including lipid, protein, polysaccharide, and carotenoid, etc. are gaining significant attention in energy development and waste resource utilization. Among a variety of high-value feedstocks, microalgae are particularly promising because of their high value biochemicals
Chronic unpredictable environmental stress is harmful to humans
Stress refers to the mental and emotional change of state from normal homeostasis. In another words we can say that stress happens when we are worried for something and feeling uncomfortable. Chronic unpredictable environmental stress (CUES) refers
Cuddling of babies born extremely preterm before admission to the Neonatal Intensive Care Unit
Delivery of a baby before 37 weeks’ gestation is known as premature birth. Some babies may be born more than 12 weeks early – at 27 weeks’ gestation or even less. This is commonly termed ‘extremely preterm’.
Function matters: visual stimulation protects the retina against ischemia
Retinal ischemia is a condition involved in several prevalent retinal degenerative diseases such as glaucoma and diabetic retinopathy, which cause visual impairment and blindness. Current research focuses on the development of neuroprotective strategies against ischemic retinopathies, but
Why constrain human taxonomic diversity?
Although the discovery of ancient humans remains was first reported in 1833, the Neanderthal bones from Feldhofer Grotto were the first to receive a species name: Homo neanderthalensis (King 1865). In 1894, Dubois boldly referred “ape-man” specimens
Allosteric degraders of EGFR leading to cancer cell detachment-promoted death
Epidermal growth factor receptor (EGFR) allosteric tyrosine kinase inhibitors (TKIs) have emerged as a therapeutic option for overcoming drug resistance in cancer. We have developed furfuryl derivatives of 4-allyl-5-[2-(4-alkoxyphenyl)-quinolin-4-yl]-4H-1,2,4-triazole-3-thiol and have shown that these compounds bind to
The minimally invasive and percutaneous ways: A tale of two approaches for heart valve implantation
Over the decades, advances in medicine have led to large increases in life-expectancy, a fact most are grateful for. However, accompanying this boost in longevity we also find a rise in what are known as “aging-related diseases”,
How to reduce salt in bread by fooling taste
Reducing sodium dietary intake is a global priority in public health. The World Health Organization (WHO) recommends sodium intake for adults to be 2 g/day maximum, equivalent to 5 g/day of cooking salt (sodium chloride, NaCl), whereas
Plasma cell myeloma: an integrated diagnosis of multiple dimensions
Plasma cell myeloma, a neoplastic proliferation of plasma cells, is one of the most common malignancies in the world. The clinical symptom and treatment response of individual patient are variable, which may relate to the underlying heterogeneous
Lipids keeps shrinking with aging and neurodegeneration
I remember when my Biology teacher at the secondary school introduced us for the first time to the biochemical components of the living cells. I was immediately fascinated by the elegant code making of the nucleic acids,
Prevention of congenital heart anomalies: the secret kept by embryonic stem cells
CITED2 is a transcriptional modulator involved in the regulation of the expression of many other genes in vertebrates. At very early stages of embryo development, CITED2 is particularly important for heart formation, a process also termed cardiogenesis.
DFT for designing efficient supercapacitor electrode materials
Josef MacDouall once said “Chemistry is a game that electrons play”. If one were able to know the roles, they could control the game and uncover the mysteries of materials, which are the backbone of our modern
When will my mouse die?
The maintenance of health is ensured by the function of the three homeostatic systems of the body: the nervous, endocrine and immune systems, and by the net that allows crosstalk between them: the neuroimmunoendocrine communication. With aging,
