Enrichment, quantification and glycan analysis of prostate cancer oncomarker in a single step
In recent decades, there is an increasing trend in prostate cancer occurrence and mortality worldwide, caused partly by a more available diagnostics, prolonged life period but also increased risk factors present in the environment. Most commonly, age
New way to control parasites in grazing animals
Gastrointestinal nematodes are parasitic worms that pose a major threat to the health and productivity of grass-eating animals such as horses, sheep, cattle and goats. They live in the animals’ digestive system and suck their blood. Young
VMAT2: a novel biomarker for myopia
Myopia, with increasing prevalence and earlier age-of-onset, is the most common eye disease in the world. But its etiology is still unclear. Lots of studies have confirmed the hypothesis that dopamine (DA) is one of the important
Can glucose or fructose consumption impair memory?
The intake of simple sugars in the human diet has risen in the last decades, especially due to the elevated consumption of sugar-sweetened beverages. This increase in simple sugar consumption has been associated with metabolic pathologies, such
Diagnostics of seronegative rheumatoid arthritis using glycomic tools and machine learning
Rheumatoid arthritis (RA) is an inflammatory disease characterized by synovium swelling and destruction. There are two different types of rheumatoid arthritis, sometimes even believed to be two distinct disorders, namely seropositive (S+) and seronegative (S-) rheumatoid arthritis.
Targeting microRNAs for thyroid cancer therapy
The thyroid gland is a small butterfly-shaped endocrine organ located at the base of the throat, just below the Adam´s apple. Its function is to concentrate dietary iodine from the bloodstream and produce thyroid hormones, which have
An epigenetic treatment strategy puts a brake on alcohol dependence
Alcohol use disorder, commonly known as alcoholism, is a chronic debilitating psychiatric disease that affects >16 million people in the United States. Disease progression of alcoholism cycles through several different stages, characterized by preoccupation or needing to
Cost-effectiveness of rapid diagnosis of drug-resistant tuberculosis
Globally, tuberculosis (TB) is a leading cause of premature death. There are treatments for tuberculosis, but drug-resistant strains of tuberculosis have emerged, mostly due to improper or incomplete treatment. If diagnosed properly in a timely manner, extremely
Nodding syndrome, a form of river epilepsy
Nodding syndrome (NS) is a devastating epileptic condition appearing in previously healthy children between 3 and 18 years old. It is characterized by brief episodes of sudden forward dropping of the head (nodding), often accompanied by declining
Novel biosensors for the rapid detection of toxicants in foods
The specific objective of this monograph is mainly to exploit progress in nanosciences to deploy nanotechnology in affordable, mass-produced sensors, and to integrate these into components and systems (including portable ones) for mass market applications in environmental
A novel electrochemical sensor based on molecularly imprinted polymer modified MOF derived exfoliated porous carbon
In this work, we report a novel hybrid electrochemical sensor coupling exfoliated porous carbon (EPC) with molecularly imprinted polymer (MIP) for detection of lidocaine (LID). LID is a local anesthetic and antiarrhythmic drug. It is also the
The use of dry powder mannitol in respiratory disease
Asthma is an inflammatory disease of the airways causing them to be hyperresponsive to a wide range of stimuli. It is a common disease both in children and adults and most asthmatics suffer from allergies and from
College drinking culture in Spain, Argentina, and USA: An examination of impulsivity, college alcohol beliefs, and alcohol outcomes
Across many countries and cultures, college students drink heavily. Students who drink heavily are at risk for a wide range of problems ranging from hangover to unsafe and unplanned sex to poor academic performance to developing an
Treatment of elderly patients with pancreatic cancer
Our publication is about elderly patients’ treatment evaluation for pancreatic cancer in the United States. This is a Surveillance, Epidemiology, and End Results (SEER)-Medicare analysis of patients above age of 65 who have Medicare and were treated
Nucleophosmin holds it all together, the smart glue of the nucleolus
The nucleolus is an organelle that serves as a factory for ribosome production and a stress sensor in the nucleus of eukaryotic cells. Unlike the nucleus, the nucleolus is not surrounded by a membrane. Instead, the nucleolus
Fibroblasts in rheumatoid arthritis: From friend to foe
Our joints are composed of tissue-resident cells, called fibroblasts, which are responsible for maintaining the structure of the joint and repairing damaged tissue. Additionally, we and others have shown that fibroblasts can also influence the types and
TussisWatch: a smartphone system to identify cough episodes as early symptoms of chronic diseases
Chronic Obstructive Pulmonary Disease (COPD) and Congestive Heart Failure (CHF) are progressive diseases and often the terminal stage of heart and lung disease, leading to death and disability. Both of these diseases may manifest with similar conflicting
The discovery of anticancer compounds as a highly potent and selective Cyclin-Dependent Kinases 4 and 6 inhibitors
Cell cycle is a highly regulated process that leads to the transition from quiescence or cytokinesis to cell proliferation through its checkpoints ensures genome stability. More importantly, cyclins and cyclin-dependent kinases (Cdks) play an important role in
A culture medium for screening pandrug- resistance to aminoglycosides in Gram-negative bacteria
Multidrug resistance in Gram negatives is now recognized as an issue of worldwide interest. Those bacteria possess various resistance mechanisms compromising the efficacy of several class of antibiotics such as beta-lactams and aminoglycosides. Therefore, it is essential
Pathophysiological advantages derived from simultaneous measurement of diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO)
It has been over 100 years since Marie Krogh developed the method to measure the transfer of carbon monoxide (CO) through the alveolar wall. Since then, the single-breath CO diffusing capacity (DLCO) has become the most clinically
