The primary cilia bend with the flow but do they sense the pH?
Cilia are minuscule hair-like projections rising out of most cells in the body. Among these cellular protrusions known as cilia, some can generate movement, rotate or flick while the primary cilia sway helplessly to the flow of
Alterations in mitochondrial metabolism induced by chronic fluoride exposure
Fluoride (F) is widely available in nature and has been successfully used to control dental caries worldwide. In addition, beneficial effects have been shown on the development of teeth and bones. However, high concentrations of F over
Importance of drinking microfiltered raw immune-milk from cows immunized against SARS-CoV-2 in providing short-term protection against COVID-19
COVID-19 is the infectious disease caused by the novel coronavirus SARS-CoV-2, which causes severe respiratory tract infections in humans, has become a global health concern. Currently, all the effort used to prevent the spread of this virus
Gelation of textile effluent by fish scales: An innovation in liquid waste management
Fish wastes (such as heads, bones, skin, scales, fins, and viscera) often might account up to three fourths of the total fish weight and are dumped carelessly into land or sea, resulting in a negative environmental impact.
Metformin improves pancreatic cancer and lymphoma outcomes in DM2 patients
Type 2 diabetics are at increased risk of cancer in part because of increased insulin in the blood from insulin resistance. Insulin and its related growth factor IGF-1 can stimulate cell growth through the Ras-Raf-MEK-ERK or the
Antigen-expressing regulatory T cells can protect against allergic reactions
Our immune systems are designed to protect us from dangerous foreign invaders, like viruses, bacteria or parasites. However, sometimes we respond to usually harmless foreign materials, e.g. pollens or food, the results of which can be mild
Bioactive extracts from Posidonia oceanica waste biomass: Are organic solvents necessary?
Bioactive compounds with antioxidant and antimicrobial activity have found applications in a broad range of areas within the pharmaceutical and food industries. As a result, the prospection of new biomass resources to obtain natural extracts with these
Fullerene soot nanoparticles impose threat to glial cell community
Nanotechnology principally deals with engineering or fine tuning of functional matters at their molecular level. The field has generated an exciting scientific attention globally because of the innumerable possibilities it holds. Since it offers opportunities to mold
A systematic mapping study of design and deployment models in cloud computing
In the traditional system of computing, all that is required in terms of applications, runtime, operating system and networking are provided by the organization. In cloud computing, various levels of resources are available at a cloud service
Insight into the needs of thyroid cancer patients before surgery
The thyroid is a butterfly-shaped gland in the neck below the Adam’s apple. It produces hormones that help influence our metabolism and normal development. Over the last 30 years, the number of new thyroid cancer diagnoses has
The protein TMEM147 is a novel regulator of cholesterol homeostasis in human cells
In terrestrial vertebrate animals, cholesterol is a major sterol lipid with multiple, critically important biological roles. In cells, it is a key constituent lipid of the plasma membrane, affecting its fluidity and stiffness and acting as an
EEG reactivity in coma
The electroencephalogram (EEG) is a test of brain activity applied on Hospital Intensive Care Units (ICUs) to detect seizure activity, with up to half of ICU patients having seizures associated with their neurological condition. For this reason,
Epigenetic phenotype diversification helps animals to adapt to changing and new environments
There is increasing evidence that epigenetic phenotype variation can contribute to environmental adaptation, speciation and evolution. Epigenetic changes of the phenotype are caused by differences in gene expression rather than by alteration of the genetic code. Epigenetic
Effect of synergism of small molecules against fibrillation process of human serum albumin
There are different ways by which small molecules interact with protein and its aggregates. One of it is synergistic interaction of drugs or small molecules against protein aggregates. Protein aggregation is a common cause of neurodegeneration. Most
Reprogramming skin into brain to study aging and age-related brain diseases
“Inevitable as the passing of time” is a common phrase and a simple truth; in our lives, we may have impactful experiences, grow and learn but, inescapably, we age. It is clear that as we age, our
How can we remove radioactive Cs from nanosheet edges of clay in soil environment?
There has been steady progress in the decontamination work of radioactive Cs originating from the Fukushima Daiichi Nuclear Power Plant accident of Tokyo Electric Power Company in 2011. According to the Ministry of the Environment, Government of
Adverse Drug Reactions: power, harm reduction, regulation and the ADRe profile
Patients should be checked systematically to ensure that they are not being harmed by their medication. Through case studies of prescriptions of antipsychotics to older adults in the UK, we have shown that if healthcare professionals systematically
Trends in heart failure diagnosis for women and men in urban and rural settings in Ontario
Heart failure remains a significant cause of death and disability for women and men. It is estimated that 1 in 5 individuals will be diagnosed with heart failure in their lifetime, with an average survival of approximately
Any cell organelle can be the starting point for toxicant and pathogen-induced cell death
Toxicants and pathogens often induce death of their target and host cells. In order to investigate the different ways they can achieve this I have used the hepatopancreatocytes of decapod crustaceans as an example, Specifically, I tried
How can we tuned magnetic response of a composite particles to an applied field
Composite particles contain two or more components and therefore they could have several advantages over single component particles, as multifuntionality, novel functions or enhanced properties. Their properties are induced by interactions between the constituents and depend not
