Mapping red nucleus connections in humans by using dMRI and tractography

Human brain is an enormous and complex network. Central to current scenario on brain networks is the concept of the connectome More »

Curiosity and flexibility help birds to master rapid environmental change

Birds are one of the most mobile organisms on earth due to their ability to fly. This allows them to use areas far apart for breeding and non-breeding More »

Virus chainmail: protective and porous metal-organic framework grown on a virus

Biomineralization describes a process of programmable accumulation, concentration, and construction of inorganic ions regulated by organisms to form both amorphous More »

Species are always important

This review is based on the premise that all species are important to life on earth even if the exact role or value of a species has not been formally documented More »

 

Enrichment, quantification and glycan analysis of prostate cancer oncomarker in a single step

In recent decades, there is an increasing trend in prostate cancer occurrence and mortality worldwide, caused partly by a more available diagnostics, prolonged life period but also increased risk factors present in the environment. Most commonly, age

New way to control parasites in grazing animals

Gastrointestinal nematodes are parasitic worms that pose a major threat to the health and productivity of grass-eating animals such as horses, sheep, cattle and goats. They live in the animals’ digestive system and suck their blood. Young

VMAT2: a novel biomarker for myopia

Myopia, with increasing prevalence and earlier age-of-onset, is the most common eye disease in the world. But its etiology is still unclear. Lots of studies have confirmed the hypothesis that dopamine (DA) is one of the important

Can glucose or fructose consumption impair memory?

Can glucose or fructose consumption impair memory

The intake of simple sugars in the human diet has risen in the last decades, especially due to the elevated consumption of sugar-sweetened beverages. This increase in simple sugar consumption has been associated with metabolic pathologies, such

Diagnostics of seronegative rheumatoid arthritis using glycomic tools and machine learning

Rheumatoid arthritis (RA) is an inflammatory disease characterized by synovium swelling and destruction. There are two different types of rheumatoid arthritis, sometimes even believed to be two distinct disorders, namely seropositive (S+) and seronegative (S-) rheumatoid arthritis.

Targeting microRNAs for thyroid cancer therapy

Schematic model explaining the oncogenic actions of miR-146b and the consequences of its inhibition in thyroid cancer

The thyroid gland is a small butterfly-shaped endocrine organ located at the base of the throat, just below the Adam´s apple. Its function is to concentrate dietary iodine from the bloodstream and produce thyroid hormones, which have

An epigenetic treatment strategy puts a brake on alcohol dependence

An Epigenetic Treatment Strategy Puts a Brake on Alcohol Dependence

Alcohol use disorder, commonly known as alcoholism, is a chronic debilitating psychiatric disease that affects >16 million people in the United States. Disease progression of alcoholism cycles through several different stages, characterized by preoccupation or needing to

Cost-effectiveness of rapid diagnosis of drug-resistant tuberculosis

Globally, tuberculosis (TB) is a leading cause of premature death. There are treatments for tuberculosis, but drug-resistant strains of tuberculosis have emerged, mostly due to improper or incomplete treatment.  If diagnosed properly in a timely manner, extremely

Nodding syndrome, a form of river epilepsy

Naam river in Mvolo village (South Sudan)

Nodding syndrome (NS) is a devastating epileptic condition appearing in previously healthy children between 3 and 18 years old. It is characterized by brief episodes of sudden forward dropping of the head (nodding), often accompanied by declining

Novel biosensors for the rapid detection of toxicants in foods

Different enzymes commonly used in biosensors

The specific objective of this monograph is mainly to exploit progress in nanosciences to deploy nanotechnology in affordable, mass-produced sensors, and to integrate these into components and systems (including portable ones) for mass market applications in environmental

A novel electrochemical sensor based on molecularly imprinted polymer modified MOF derived exfoliated porous carbon

In this work, we report a novel hybrid electrochemical sensor coupling exfoliated porous carbon (EPC) with molecularly imprinted polymer (MIP) for detection of lidocaine (LID). LID is a local anesthetic and antiarrhythmic drug. It is also the

The use of dry powder mannitol in respiratory disease

The use of dry powder mannitolin respiratory disease

Asthma is an inflammatory disease of the airways causing them to be hyperresponsive to a wide range of stimuli. It is a common disease both in children and adults and most asthmatics suffer from allergies and from

College drinking culture in Spain, Argentina, and USA: An examination of impulsivity, college alcohol beliefs, and alcohol outcomes

College drinking culture in Spain, Argentina, and USA

Across many countries and cultures, college students drink heavily. Students who drink heavily are at risk for a wide range of problems ranging from hangover to unsafe and unplanned sex to poor academic performance to developing an

Treatment of elderly patients with pancreatic cancer

Our publication is about elderly patients’ treatment evaluation for pancreatic cancer in the United States. This is a Surveillance, Epidemiology, and End Results (SEER)-Medicare analysis of patients above age of 65 who have Medicare and were treated

Nucleophosmin holds it all together, the smart glue of the nucleolus

Conformational changes in nucleophosmin

The nucleolus is an organelle that serves as a factory for ribosome production and a stress sensor in the nucleus of eukaryotic cells. Unlike the nucleus, the nucleolus is not surrounded by a membrane. Instead, the nucleolus

Fibroblasts in rheumatoid arthritis: From friend to foe

Fibroblast effects on leukocytes

Our joints are composed of tissue-resident cells, called fibroblasts, which are responsible for maintaining the structure of the joint and repairing damaged tissue. Additionally, we and others have shown that fibroblasts can also influence the types and

TussisWatch: a smartphone system to identify cough episodes as early symptoms of chronic diseases

Variance Trends for Different Subsets and Two Levels of Validation

Chronic Obstructive Pulmonary Disease (COPD) and Congestive Heart Failure (CHF) are progressive diseases and often the terminal stage of heart and lung disease, leading to death and disability. Both of these diseases may manifest with similar conflicting

The discovery of anticancer compounds as a highly potent and selective Cyclin-Dependent Kinases 4 and 6 inhibitors

2D model of Abemaciclib bound to the active site of CDK6

Cell cycle is a highly regulated process that leads to the transition from quiescence or cytokinesis to cell proliferation through its checkpoints ensures genome stability. More importantly, cyclins and cyclin-dependent kinases (Cdks) play an important role in

A culture medium for screening pandrug- resistance to aminoglycosides in Gram-negative bacteria

Multidrug resistance in Gram negatives is now recognized as an issue of worldwide interest. Those bacteria possess various resistance mechanisms compromising the efficacy of several class of antibiotics such as beta-lactams and aminoglycosides. Therefore, it is essential

Pathophysiological advantages derived from simultaneous measurement of diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO)

Schematic presentation of CO and NO transfer

It has been over 100 years since Marie Krogh developed the method to measure the transfer of carbon monoxide (CO) through the alveolar wall. Since then, the single-breath CO diffusing capacity (DLCO) has become the most clinically