Monthly Archives: November 2015

Treatment sequencing in metastatic castrate-resistant prostate cancer

The treatment of metastatic castrate resistant prostate cancer (mCRPC) has been rapidly advancing. Years of research effort have culminated, in the approvals of five active agents that prolong patient survival. However, as a practicing clinician, I and

Improved prediction of accessible surface area

Protein consists of a linear chain of amino acid residues connected by peptide bond. Protein performs an array of functions by its three dimensional (3D) shapes or structures and the shape can be determined from its one

A small RNA, microRNA-155, “micromanages” inflammation and renewal of neurons in the brain

The immune system is like a silent army, protecting the body from enemy viruses and bacteria. Inflammation is part of this response, acting to eliminate pathogens and initiate tissue repair. Most of the time, our immune systems

Crude glycerin, byproduct from biofuel, improved quality of lamb meat

Crude glycerin is a byproduct from biodiesel industry with potential to replace corn in ruminant diet, as an energy source. It provides a substrate that increases the availability of carbon for fatty acid synthesis. Therefore, the substitution

How did new species arise?

How did new ways of life and new adaptations to the surroundings evolve in our early ancestors? And how did new species arise? These questions are at the heart of understanding the evolutionary origin of our species

Archaeological surprise! Lucy has company

One of the most remarkable discoveries in the human fossil record is an Australopithecus afarensis partial skeleton nicknamed Lucy dated to 3.2 million years before present. Discovered in 1974 by Donald Johanson and his colleagues, the skeleton

Small molecule antagonists maintain stem cell potency

The decision for a stem cell to make an exact copy of itself and maintain the same level of potency versus initiate a differentiation program is critical both during development and normal tissue maintenance. CBP and p300

The development of a new blood substitute

The first transfusion ever performed is generally attributed to James Blundell in the beginning of the eighteenth century. Since Blundell’s experiments until the beginning of the twentieth century, transfusion was considered an extremely risked procedure with general

What Saudi women don’t know is killing them

Dozens of types of human papillomaviruses (HPVs) have been identified. While low-risk HPVs cause skin and genital warts, high-risk HPVs can lead to cancers of the cervix, vulva, vagina, penis, oropharynx, and anus. Recent studies have reprted

Phospholipase A2 group IVc blocks mammary tumor apoptosis

The Hirosaki hairless rat (HHR) is a mutant rat strain with autosomal recessive inheritance spontaneously derived from the Sprague-Dawley rat (SDR). The hairless phenotype of HHRs is due to the deletion of basic hair keratin genes, and

Sugars in circulating blood reflect breast cancer biology

In our studies, consisting of measurements and analyses, we have shown that the sugar composition in the serum of breast cancer patients reflects the biology of their breast tumours. Patients with different kinds of breast tumours have

Indoor air quality is strong affected by ambient air

Air pollution is now a major concert of public of China as well as many developing country. Monitoring data show severe ambient air pollution in many large cities. Since most people spend a large fraction of time

Technology to seek the elixir of hunger and satiation

Nowadays eating too much food or not enough are major social problems. Can we find identify medicine to promote either behaviour? Serendipity still drives first-in-class medicine identification. Hence, increasing the number of drugs tested increases the odds

Differentiation of pathogenic races of the lentil anthracnose pathogen C.lentis using effectors

The genus Colletotrichum has been under revision for the last decade. It contains species of high economic importance as pathogens of major crops, but also includes species that are model organisms to study host-pathogen interactions. The hemibiotroph

Effect of resveratrol on chemotherapy of a fatal childhood cancer

The natural polyphenolic compound resveratrol, found in red wine, dark chocolate, and peanuts, may confer health benefits in humans. It is a powerful antioxidant that has been suggested to alleviate age-related pathologies, such as type II diabetes,

Mother sharks transfer radioactive contaminants to their young

When nuclear accidents like that at the Fukushima Dai-ichi Nuclear Power Plant release man-made radionuclides into coastal marine waters the resident biota are exposed by way of several environmental pathways. The commonly studied pathways for fishes are

Determination of breath alcohol value after using mouthwashes containing ethanol

Mouthwashes are devices frequently used and suggested by dentist. Some mouthwashes contain ethanol (MCE), in order to improve their antibacterial activity. In Italian legislation there are a series of judgments reporting cases of drivers who resulted positive

Canine demodicosis – how to solve a problem ASAP?

Demodex mites cause disease in the skin of immune debilitated dogs. Demodex are species-specific, follicular mites that are found as a normal resident on most species of animals and in humans. Demodicosis is rare in the horse,

Simple method for measuring important components of cannabis in blood

The first recorded use of cannabis sativa, commonly called hemp, was by the ancient Chinese as early as 4000 BC. It was used as a fiber source for textiles, ropes, and paper. In addition, medical and entertainment

Highlighting inflammatory markers in anxiety disorders

Anxiety disorders, often originating early in life, are very common and effect 28.3% of the population. With this high prevalence comes an associated cost to the economy, mostly related to the extensive overuse of primary care services