Monthly Archives: September 2016

Microfluidic tumor models help pre-clinical screening of T cell cancer immunotherapies

Cancer immunotherapy draws upon the patient’s own immune system to recognize and fight the disease. One form of cancer immunotherapy is known as adoptive T cell therapy (ACT) consisting of isolation, genetic manipulation and reinfusion into the

Using social media to improve parent-child relationships?

My 6- and 4-year-old boys give me lots of fun despite the troubles that they make every day. The two of them differ in intellectual development, but both have become more eager to know “why”—when my wife

3,3′-diindolylmethane is a novel signalling molecule in Canola plants

Glucosinolates are organic compounds which exist in the Brassica family of plants and which are derived from glucose and amino acids and consists of sulphur and nitrogen in their structure. Glucosinolates exist as many different compounds in

Simple mathematical formulas for tracking the number of antibiotic resistance cases globally

In order to continue to live, microbes and germs have found ways to prevent drugs from killing them in the process of curing patients—when the patients ingest the drugs for treatment. Microbes destroying drugs within patients and

Do surgeons need to rewash their hands during operations that last long?

More than one hundred and fifty years ago surgical pioneers like Ignaz Semmelweis and Joseph Lister introduced hand washing and sterile surgical techniques to prevent surgical site infection (SSI). However, despite advances in infection control practices over

Spectroscopy of biophotons radiated from a fingertip

What color of light beams are emitting from your fingertips? That is neither a fantasy nor an occult question. If you possessed eyes of extremely high-sensitivity or had a special CCD camera like one used for a

What do we know about weight regain following the sleeve gastrectomy weight loss operation?

Obesity is increasingly common and has devastating effects on society.  When an individual is obese, they are more likely to have heart disease, lung disease, diabetes and cancer.  Furthermore, obese people have less quality of life and

The old-generation smallpox vaccines – Are we ready for the tomorrow outbreak?

Smallpox disease has menaced the world throughout history with large scale epidemics and a case fatality rate of about 30%.  Following the introduction of smallpox vaccine by Eduard Jenner in 1796, and later with the global effort

Recognizing the clinical presentation of pachydermodactyly

Pachydermodactyly (PDD) is a unique, benign soft tissue disorder affecting the hands, first reported in 1975. Patients with PDD typically present with painless swelling at the middle joint of the fingers, although in rare cases this swelling

The mood stabilizer valproic acid tunes up abnormal circadian rhythms in mania

Circadian clocks rule our lives. In the course of evolution, almost all living creatures developed molecular mechanisms that optimally prepare our bodies for predictable , recurring events related to the regular alternations between day and night. This

Parents supporting parents: Development and evaluation of a peer parent program for perinatal loss

The loss of a pregnancy or newborn ( i. e., perinatal loss ) can be one of the most traumatic experiences parents can face. The most common type of loss is miscarriage ( i. e., loss occurring

Prevalence of hospitalisation resulting from medicine related problems among adult patients with cardiovascular diseases and/or diabetes

Cardiovascular diseases ( CVDs ) and diabetes ( DM ) are two interrelated groups of diseases that contribute to more than 50 % of death worldwide. Patients with CVDs and / or DM often take multiple medicines

The protein p62 helps liver cancer-initiating cells survive

The most common form of adult liver cancer is hepatocellular carcinoma (HCC), which is the third-leading cause of cancer deaths worldwide. HCC arises from persistent liver inflammation related to hepatitis B or C infection, alcohol consumption, or

Verapamil and a loop diuretic modestly reduce the intracellular pH of cortical neurons: a contribution to their anti-seizure potency?

A tight regulation of the intracellular pH ( pHi ) is needed to preserve essential cell functions, e. g. involved in cell communication and viability ( Fig. 1A ). In mammalian cortical neurons, pHi – regulation is

A novel approach to reliably predicting efficient visual search

Working memory load is the capacity of mental effort we put into memorizing information over a period of time. Researchers use an eye-tracker as a passive implicit input device to measure eye movement as an indicator of

Wheat microRNA ancestors

Bread wheat, Triticum aestivum L., is one of the most important crops as a food source by providing approximately 20 % of human dietary energy. Bread wheat is harvested all over the world distributed more than 200

Bioethanol production from corn waste following an optimized hydrothermal pretreatment process

Depletion of crude oil reserves alongside rapid climate change due to greenhouse gas emissions (GHG) have led scientific community to seek alternative energy sources. Renewable energy sources such as 2nd generation biofuels have garnered a lot of

Cancer can growth without angiogenesis. A new field opened in cancer biology

The word cancer derives from the Greek “karkinos “which means “crab”.  According to the legend reported by Paul of Aegina in the 7th Century AD, this name was chosen because this disease “has the veins stretched on

How does fever work? As a non-specific stressor

Despite the spectacular discoveries in immunology and recent biotechnological advances, amazingly there has been no consensus on how fever functions to help control infections. Does the heat of fever act as an immune stimulant, or does it

Abdominal wall schwannoma

A 62-year-old woman was admitted to our institution for the surgical evaluation of a mass in the right iliac fossa causing an enduring abdominal pain. The patient presented with the following comorbidities: visceral class I obesity (BMI