Monthly Archives: August 2018
Pharmacological approaches targeting immune cell and oxidative biology in allergic asthma
Airway inflammation is one of the central features of asthma and chronic obstructive pulmonary disease (COPD). The mechanisms associated with the development and progression of airway inflammation have been widely studied in multiple populations and animal models.
Post trauma: to filter or not to filter
Pulmonary embolism (PE) remains a significant cause of death in trauma patients. However, this patient population is also at risk of ongoing bleeding, making anticoagulation (Heparin, Coumadin, etc.) impractical. This puts trauma surgeons and vascular surgeons alike
Zebrafish is an attractive model to anticipate drug-induced renal injury in humans
Most of the innovative drugs with important therapeutic benefits are not approved or are removed from the clinical practice due to drug-induced toxicity. The kidneys are one of the most important target organs of drug toxicity because
Bioinformatics solutions for big data analysis in life sciences presented by the German network for bioinformatics infrastructure
Over the last decade, the amount of data generated by life science research has grown at a rapid rate and an increased complexity rendering the tasks of data analysis, management, and storage a unique challenge. To meet
Acridone-pyrimidine hybrid molecules: potential anticancer agents
Cancer is one of the world’s most pressing challenge to research community and leading cause of death. As per the 13th report of American Science of Clinical Oncology, 14 million people are diagnosed with cancer every year.
Role of lymphadenectomy in non-small cell lung cancer surgical management
The prognosis and survival of non-small cell lung cancer (NSCLC) patients is dependent on the stage of disease, which is based on tumor size and nodal and distant metastasis at presentation. In turn, cancer stage assessment is
Role of the gut in systemic inflammation
The multi-layer wall of the intestine is unique and important due its barrier function for billions of potential deadly gut bacteria and the sterile tissues in the body. For this reason, the intestine is equipped with highly
An in-silico meta-analysis of cell-type-specific non-CpG methylation
Nowadays, the amount of raw data required for a genome-wide analysis is quite large and it is often difficult for even its original author(s) to spend enough time for its thorough analysis. Further, it would be practically
Unknown sonochemistry
The chemical effects of ultrasound, named sonochemistry, are known since 1927. Today, there is a consensus within the scientific community that sonochemistry arises from the violent collapse of microbubbles formed in liquids submitted to power ultrasonic waves.
High-accuracy and high-sensitivity optical tracing of dinitrogen pentoxide (N2O5) involved in a nocturnal tropospheric chemical reaction process in smog chamber using quantum cascade laser
Dinitrogen pentoxide (N2O5) is an important reactive intermediate in the atmospheric chemistry of nitrogen oxides and nitrate aerosol, especially during night-time. It is also an important reservoir of NO3 radical that can react with various volatile organic
Waste to wealth: hydrothermal liquefaction of agricultural and forestry wastes into value-added chemicals
Hydrothermal liquefaction has been widely applied to obtain bioenergy and high -value chemicals from biomass in the presence of a solvent at moderate to high temperature (200 °C to 550 °C) and pressure (5 MPa to 25
‘Functional’ role of ‘Anchoring’ Hemidesmosomal Linker proteins
Oral squamous cell carcinoma (OSCC) is one of the leading cancers in India. Currently, there are no specific biomarkers which can be used for prognostication of human oral cancer. Intermediate filament (cytoskeletal proteins) and their associated proteins
Curvilinear accuracy of digital models
The use of digital services became a common practice in dental offices worldwide via the advances in computer technology. The most efficient way to obtain digital dental models is through the utilization of intraoral scanners. As digital
Magnetic field properties of magnets designed for nuclear magnetic resonance applications
The spectral resolution of NMR experiments is heavily reliant on the spectrometer’s magnetic field strength and especially its homogeneity. While superconducting magnets can produce strong and highly homogeneous magnetic fields, they are expensive to maintain due to
How does Parkinson’s disease gets from your gut to your head?
Parkinson’s disease (PD) is defined as a movement disorder, characterized by a symptomatic phase of motor disturbances such as tremor and slow movements resulting from the severe degeneration of dopaminergic neurons of the substantia nigra pars compacta
Mimicking enzymes using artificial proteins
Critical to life on earth is the ability of proteins called enzymes to catalyze a wide range of chemical reactions, such as producing essential molecules by breaking down food in humans, and producing oxygen from water in
Multi-scale mechanical characterization of prostate cancer cell lines
Cellular mechanics are of prime importance in the birth and the evolution of tumors towards increasingly aggressive stages and are often proposed as potential biomarkers to evaluate metastatic potential. Mechanical properties of two human prostate cell lines,
Decrypting the secret of Swarna Bhasma, an ancient Ayurvedic/Sidha medicine. Swarna Bhasma, ancient Ayurvedic medicine, meets human cells
Ayurveda is an indigenous medical system of natural healing, with roots in folk medicine, in practice on the Indian subcontinent since at least 5000 years. It adopts a holistic approach towards health, emphasizing the connection between the
Unregulated oxygen levels in mammalian cell culture changes cell physiology
As aerobic organisms we continuously utilize oxygen from the surrounding environment which ultimately participates in the formation of useful bioenergetic intermediates. Approximately 21% of the air we breathe is composed of oxygen, but the quantity of oxygen
Does inadequate sleep hours and snoring relate to chronic disease?
Sleep is one of the fundamental requirements for survival of human beings. Yet an outrageous number of population neglect its’ importance. Although most people tend to think that lack of sleep (<7 hours) is more detrimental to
