Monthly Archives: August 2018

Post trauma: to filter or not to filter

Pulmonary embolism (PE) remains a significant cause of death in trauma patients. However, this patient population is also at risk of ongoing bleeding, making anticoagulation (Heparin, Coumadin, etc.) impractical. This puts trauma surgeons and vascular surgeons alike

Zebrafish is an attractive model to anticipate drug-induced renal injury in humans

Most of the innovative drugs with important therapeutic benefits are not approved or are removed from the clinical practice due to drug-induced toxicity. The kidneys are one of the most important target organs of drug toxicity because

Bioinformatics solutions for big data analysis in life sciences presented by the German network for bioinformatics infrastructure

Over the last decade, the amount of data generated by life science research has grown at a rapid rate and an increased complexity rendering the tasks of data analysis, management, and storage a unique challenge. To meet

Acridone-pyrimidine hybrid molecules: potential anticancer agents

Cancer is one of the world’s most pressing challenge to research community and leading cause of death. As per the 13th report of American Science of Clinical Oncology, 14 million people are diagnosed with cancer every year.

Role of lymphadenectomy in non-small cell lung cancer surgical management

The prognosis and survival of non-small cell lung cancer (NSCLC) patients is dependent on the stage of disease, which is based on tumor size and nodal and distant metastasis at presentation. In turn, cancer stage assessment is

Role of the gut in systemic inflammation

The multi-layer wall of the intestine is unique and important due its barrier function for billions of potential deadly gut bacteria and the sterile tissues in the body. For this reason, the intestine is equipped with highly

An in-silico meta-analysis of cell-type-specific non-CpG methylation

Nowadays, the amount of raw data required for a genome-wide analysis is quite large and it is often difficult for even its original author(s) to spend enough time for its thorough analysis. Further, it would be practically

Unknown sonochemistry

The chemical effects of ultrasound, named sonochemistry, are known since 1927.  Today, there is a consensus within the scientific community that sonochemistry arises from the violent collapse of microbubbles formed in liquids submitted to power ultrasonic waves.

High-accuracy and high-sensitivity optical tracing of dinitrogen pentoxide (N2O5) involved in a nocturnal tropospheric chemical reaction process in smog chamber using quantum cascade laser

Dinitrogen pentoxide (N2O5) is an important reactive intermediate in the atmospheric chemistry of nitrogen oxides and nitrate aerosol, especially during night-time. It is also an important reservoir of NO3 radical that can react with various volatile organic

Waste to wealth: hydrothermal liquefaction of agricultural and forestry wastes into value-added chemicals

Hydrothermal liquefaction has been widely applied to obtain bioenergy and high -value chemicals from biomass in the presence of a solvent at moderate to high temperature (200 °C to 550 °C) and pressure (5 MPa to 25

‘Functional’ role of ‘Anchoring’ Hemidesmosomal Linker proteins

Oral squamous cell carcinoma (OSCC) is one of the leading cancers in India. Currently, there are no specific biomarkers which can be used for prognostication of human oral cancer. Intermediate filament (cytoskeletal proteins) and their associated proteins

Curvilinear accuracy of digital models

The use of digital services became a common practice in dental offices worldwide via the advances in computer technology. The most efficient way to obtain digital dental models is through the utilization of intraoral scanners. As digital

Magnetic field properties of magnets designed for nuclear magnetic resonance applications

The spectral resolution of NMR experiments is heavily reliant on the spectrometer’s magnetic field strength and especially its homogeneity. While superconducting magnets can produce strong and highly homogeneous magnetic fields, they are expensive to maintain due to

How does Parkinson’s disease gets from your gut to your head?

Parkinson’s disease (PD) is defined as a movement disorder, characterized by a symptomatic phase of motor disturbances such as tremor and slow movements resulting from the severe degeneration of dopaminergic neurons of the substantia nigra pars compacta

Mimicking enzymes using artificial proteins

Critical to life on earth is the ability of proteins called enzymes to catalyze a wide range of chemical reactions, such as producing essential molecules by breaking down food in humans, and producing oxygen from water in

Multi-scale mechanical characterization of prostate cancer cell lines

Cellular mechanics are of prime importance in the birth and the evolution of tumors towards increasingly aggressive stages and are often proposed as potential biomarkers to evaluate metastatic potential. Mechanical properties of two human prostate cell lines,

Decrypting the secret of Swarna Bhasma, an ancient Ayurvedic/Sidha medicine. Swarna Bhasma, ancient Ayurvedic medicine, meets human cells

Ayurveda is an indigenous medical system of natural healing, with roots in folk medicine, in practice on the Indian subcontinent since at least 5000 years. It adopts a holistic approach towards health, emphasizing the connection between the

Unregulated oxygen levels in mammalian cell culture changes cell physiology

As aerobic organisms we continuously utilize oxygen from the surrounding environment which ultimately participates in the formation of useful bioenergetic intermediates. Approximately 21% of the air we breathe is composed of oxygen, but the quantity of oxygen

Does inadequate sleep hours and snoring relate to chronic disease?

Sleep is one of the fundamental requirements for survival of human beings. Yet an outrageous number of population neglect its’ importance. Although most people tend to think that lack of sleep (<7 hours) is more detrimental to