Monthly Archives: January 2020
High phenolic content in extra virgin olive oil influences the release (time-intensity) of aroma compounds in mouth
The popularity of extra virgin olive oil (EVOO) is linked both to its pleasant sensory notes and health properties. The sensory notes of EVOO are attributed to the presence of aroma compounds while bitterness and pungency are
A mass spectrometry view of the interaction of Alzheimer’s disease proteins with an anti-aggregation compound
Alzheimer’s disease is a neurodegenerative disease that has been studied extensively over the last four decades. Millions of people worldwide are affected by this disease, and because our population is growing older, this disease is becoming alarmingly
What do patients and healthcare professionals “tweet” about brachytherapy?
Many patients post on Twitter about their healthcare experiences. Patients with cancer are especially active on Twitter, and studies have found that sharing experiences online can reduce feelings of isolation. Healthcare professionals also frequently post on Twitter.
Unboxing the role of TBX1 in palatal development: a gene profiling study
Cleft palate (CP) is a disease where there is an opening or split in the palate (the roof of the mouth). CP has been reported in 1 to 2 of every 1000 births worldwide and is the
When the obsession with healthy food becomes a problem
Healthy eating is promoted in today’s society as a positive and powerful behaviour to prevent all kinds of diseases. Therefore, making dietary restrictions and following certain food beliefs (vegetarianism, veganism, paleo diet, etc.) are behaviours considered normal
Preparation of various nucleosomes for biochemical and structural analyses
Genomic DNA, which encodes genetic information, is three-dimensionally organized in the cell as chromatin. Its basic unit is the nucleosome, a disc-like structure containing two copies each of histones H2A, H2B, H3, and H4, with DNA wound around
Role of ultrasonography in the evaluation of traumatic injury to peripheral nerves
Traumatic injury of peripheral nerve accounts for about 3-5% of limb trauma, but if not diagnosed it can be associated with negative outcomes, especially in major trauma, with economic and social damage when working-age subjects are involved.
Forward and reverse mutations in stages of cancer development
Mutations in somatic genomes are known to be the basis of cancers, understanding of which is essential for cancer prevention, diagnosis and therapy. In our study, mutations changing the genomic DNA sequences of a cell from its
Production techniques for the development of sub-micron size polymeric drug delivery formulations evaluated
Polymeric drug delivery formulations containing active pharmaceutical ingredients (APIs) offer the advantages of improved stability, targeted delivery and controlled release of APIs in vivo, which can reduce drug burden while enhancing efficacy. Poly(lactic-co-glycolic acid) (PLGA) is amongst
Dramatically distinct tropism and transduction efficiencies of AAV serotypes following subconjunctival injection
Instead of relying on traditional drug modalities, gene therapies rely on delivery of nucleic acids into patient’s cells to prevent, slow, stop or treat diseases. In the past decades, gene therapy has been broadly studied in pre-clinical
Stem cells and stem cells conditioned medium for inflammatory bowel disease treatment
Inflammatory bowel disease (IBD) is a complex of pathological processes occurring in the intestine. Chemically induced IBD in rodent usually used for study of drug therapy efficacy. Mesenchymal stem cells (MSC) was used as alternative method for
FLYWCH1 is a novel transcriptional repressor for the cancer-causing Beta-catenin
There is no doubt that cancer is a devastating disease. However, restraining the cancerous cells from spreading throughout the body (invasion) will make it easier to control and possibly cure cancer. β-catenin is one of the proteins
Local immunomodulation by Jagged-1 for islet graft acceptance
Type 1 diabetes is a chronic autoimmune disease with a high economic burden worldwide ($327 billion in 2017). Although transplantation of pancreatic islets is a promising approach for treatment of type 1 diabetes mellitus, the engraftment efficiency
Aesthetics
Our lives are full of aesthetic experiences. From the taste of coffee in the morning till a last glimpse at the stars before falling asleep, we constantly evaluate what we perceive with our senses. That is the
Confronting the paradox of irrigation efficiency
Why does the term ‘efficiency’, when applied to the irrigation sector, cause such confusion and misunderstanding? And why is promotion of increased irrigation efficiency likely to hinder achievement of the Sustainable Development Goal (SDG) 6: ‘Water for
Write my paper for me service: an effective tool to cope with academic difficulties
To be a student is not always fun. The greater part of students faces various problems. The most common of them is a lack of money, too complicated curriculum, disability to find a common language with other
Assessing extreme weather events, vulnerability, and the impacts on human wellbeing in Latin America
The increased occurrence of extreme climatological, hydrological, and meteorological events (EWEs) and Climate-sensitive Disasters (CSDs) (e.g. floods and storms) in Latin American countries (LACs), and their primary impacts on human wellbeing should be considered carefully. This requires
Moisture slows down propane diffusing through rocky pores
Natural gases emanate from the ground passing through tiny pores and fractures in silica rich rocks. These tiny pores alter the behavior of the gases passing through them. To understand the fundamental processes involved in gas migration
More Paleolithic-like lifestyles and diets associated with lower colorectal cancer risk
Colorectal cancer (CRC) is the second leading cause of cancer deaths among women and men combined in the United States. CRC incidence (i.e., the rate of new diagnoses) varies about 20-fold across countries. The incidence among immigrants
What happens inside the eye: fluid forces under physiologic movements
The vitreous is a gel-like structure that completely fills the posterior part of the eye. Doctors inject drugs directly inside the vitreous to cure sight-threatening diseases like age-related macular degeneration. These are relatively new therapies; few is
