Daily Archives: March 16, 2021

Allosteric degraders of EGFR leading to cancer cell detachment-promoted death

AoS. Allosteric Degraders of EGFR Leading to Cancer.

Epidermal growth factor receptor (EGFR) allosteric tyrosine kinase inhibitors (TKIs) have emerged as a therapeutic option for overcoming drug resistance in cancer. We have developed furfuryl derivatives of 4-allyl-5-[2-(4-alkoxyphenyl)-quinolin-4-yl]-4H-1,2,4-triazole-3-thiol and have shown that these compounds bind to

The minimally invasive and percutaneous ways: A tale of two approaches for heart valve implantation

AoS.The minimally invasive and percutaneous ways.

Over the decades, advances in medicine have led to large increases in life-expectancy, a fact most are grateful for. However, accompanying this boost in longevity we also find a rise in what are known as “aging-related diseases”,