Category Archives: Research

Analysis of serum biomarkers and their correlation with pain and quality of life in the rare disease alkaptonuria

Analysis of serum biomarkers and their correlation with pain

Alkaptonuria (AKU) is an ultra-rare disease causing an early onset, chronically debilitating spondylo-arthropathy due to deposition of an ochronotic pigment in joints and spine, which causes severe pain and greatly reduces patients’ quality of life. Despite an

Impact of decontaminant and microbiological media on Mycobacterium avium subspecies paratuberculosis

Effect of decontamination on the recovery of Map

Mycobacterium avium subspecies paratuberculosis (Map) has aetiological significance in Crohn’s disease of humans, and chronic intestinal disease in domestic and wild ruminants. This opportunistic pathogen can proliferate inside its host, whilst restricted to grow in the environment.

Are identical quantum twins distinguishable?

Entanglement in ordinary and no-label approaches

For twins, the identity is a “yes” or “not” intrinsic property: they can be identical (monozygous) or non-identical (heterozygous). Classical identical twins can always be distinguished (at least by their mother!). In fact, it is always possible

How do people’s expectations compare to the reality of their recovery after a knee replacement surgery?

Average recovery timeline

The decision to undergo a knee replacement is not one taken lightly by the patient or medical team. For many people with arthritis, medication and exercise therapies can help their symptoms, but when problems persist, a knee

Shame on me: dancing and adversity

Shame on Me: Dancing and Adversity

Professional and pre-professional dancers spend years training in order to express the deepest experiences of the human condition. They acquire physical skills that translate into aesthetic works of art. Regardless of the dance form, whether classical ballet,

Anion exchange in water: a simple way to complex and greener thermoelectrics

The need to convert and store energy in an efficient and sustainable way has already become one of the highest priorities of the new millennium. One possible solution to this challenge is the thermoelectric, which can be

Alcohol injections for the treatment of intermetatarsal neuromas

Alcohol injections for the treatment of intermetatarsal neuromas

Intermetatarsal neuromas, sometimes called Morton’s neuroma, cause nerve pain in the forefoot.  It arises due to entrapment of the nerve(s) supplying the toes(s) due to compression of the forefoot. Although any foot can be affected it’s uncommon

Three-step method for the frozen elephant trunk positioning by transesophageal echocardiography

Marking the TEE probe at aortic valve level

The frozen elephant trunk (FET) procedure has prevailed because it has simplified the treatment of complex thoracic aortic lesions. However, some procedure-related complications have been reported, and spinal cord injury is one of the most important complications.

The doors of the cell’s nucleus play a critical role in the survival and function of immune cells

Model showing the effect of Nup210 ablation in mouse CD4 T lymphocytes

Our immune system has a fascinating ability to distinguish between what does or does not belong to our body. This ability allows it to fight off infectious agents without harming our own cells. T cells are key

Unlocking the gating mechanism of the piezo1 channel with a molecular key

Unlocking the gating mechanism of the piezo1 channel

Mechanosensitive Piezo channels are large membrane proteins present at the cell membrane of eukaryotic cells. These channels open in response to the presence of mechanical forces such as frictions that occur when extracellular fluids flow against the

New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States

Diagram of deletion size and the location of each type of S1 NTD-del PEDV variant.

The Porcine Epidemic Diarrhea virus (PEDV) is an enveloped, positive-sense, single-stranded RNA virus that belongs to the genus Alphacoronavirus. This virus is known to only infect pigs and causes acute diarrhea, vomiting, and generally has a mortality

Mechanical vibrations can indicate if a fracture is healing

Mechanical Vibrations can indicate if a fracture is healing

One of the most critical issues in orthopaedics is the development of a procedure for assessing fracture healing in an objective way and by means of a non-invasive approach, replacing the actual gold standard based on X-rays.

Determining the optimum grain size is critical for invasive species distribution models

Rhododendron ponticum habitat suitability maps at 1 km, 300 m and 50 m resolutions generated in ArcGIS

Invasive species are the organisms that cause significant economic or ecological damage in their non-native environment. Invasive species are considered the second biggest threat to global biodiversity after habitat degradation. These species threaten the stability and functioning

Cells with an appetite: munching at a single-cell level

Cells with an appetite: munching at a single-cell level

Phagocytosis is defined as the receptor-mediated uptake of large particulate matter. This process is particularly efficient in specialized immune cells such as macrophages, neutrophils and dendritic cells. These cells constitute the first line of defense against invading

Large animal models for osteochondral regeneration

Comparison of common currently used large animal models

Due to the lacking of a blood supply and the low cellular density of articular cartilage, this hard tissue has a limited healing capacity. Therefore, focal traumatic events causing cartilage defects rarely resolve spontaneously or are usually

Thermo- and soluto-capillarity: Passive and active drops as micro-fluidic carriers or reactors

Why study drop (or bubble) motions? Drops can be seen free, hanging, suspended in air, sessile, aggregating, coalescing, disintegrating/splitting or spreading in nature, in engineering processing or at home. Think about dew, fogs with drops of diameters

Frac-seq uncovers widespread RNA dysregulation in severe asthma

Frac-seq uncovers widespread RNA

Asthma is a common chronic disease consisting of constriction and inflammation of the airways as well as structural changes known as remodelling (Fig. 1). 5-10% of patients have severe asthma, whereby symptoms persist despite regular and correct

Increased time incongruence between imagined and actual walking in frail older adults

Comparison of constant error in frail older and young adults

Mental chronometry is commonly used to evaluate motor imagery ability. Mental chronometry measures imagined time required for movement. Smaller differences between imagined and actual times suggest higher motor imagery. Imagined and actual times for movement tend to

Talking about childhood music: A twin study

Talking about childhood music

To what extent do childhood experiences of music practice influence thinking about music later in life? We could get an idea about this if we talk about childhood music memories while physiological recordings are made concomitantly. If we observe that there are clear

Pursuit of a genuine effect of acupuncture: development of placebo acupuncture needles

Acupuncture needles for double blinding

Acupuncture has been used to treat a wide range of health conditions. The efficacy of acupuncture has not conclusively been established because only randomized control trials using single-blind needles have been reported. Single blinding is problematic because