Category Archives: Research

Insulin and brain glucose handling

It has long been known that the brain abundantly expresses insulin receptors in all its major areas, indicating that this vital hormone controlling general glucose metabolism is important for brain function. However, mechanisms of neuro-vascular coupling at

Peculiar pollutants in the Moscow atmosphere in winter period: gas chromatography-high resolution time-of-flight mass spectrometry study

Moscow, Russia is one of the most populated cities in the world, with the metropolitan population reaching 12 million people. Moscow being also an important industrial center has several power plants, multiple industrial factories, waste incinerators, and

Unraveling the enigma of sarcoidosis

Sarcoidosis is an uncommon, genetically-conditioned disease, affecting primarily the lungs. Most cases resolve spontaneously. It is defined by a systemic granulomatous response (SGR) of unknown cause. A granuloma is a distinctive mixed-cellular immune response that reflects failure

Hypoxia mimetic blocks adipocyte differentiation but induces lipid accumulation

Obesity is one of the most immediate health threats in industrialized countries, increasing morbidity and mortality.  It is characterized by an excessive increase of white adipose tissue. Adipose tissue is a tissue with high plasticity, having the

Abl2 kinase phosphorylates bi-organellar regulator MNRR1 in mitochondria, stimulating respiration

The mitochondria are the well-known “powerhouse” of the cell. Not surprisingly, its functional state is important to other parts of the cell and, conversely, information about the needs of other parts of the cell help determine mitochondrial

Rifaximin for irritable bowel syndrome treatment

Irritable bowel syndrome is generally known as IBS. It is one of the most commonly diagnosed gastrointestinal (GI) disorders which affects about 20% of the adult US population. It is more common in women than men. Physicians

Social Entrepreneurship – applying the scientific method to solving social problems

“The business of doing good” reviews the new textbook “Introduction to Social Entrepreneurship,” a guide for aspiring entrepreneurs who want to use a data-driven approach to making a difference. Based on a course at Harvard, this book

Dinitrosyl iron complexes – natural medicinal form of NO

Everybody knows nitroglycerin – vessel-relaxing medicine effective against angina pectoris. It is a drug working as NO donor – one of the whole family of drugs used to widen our vessels and thus decrease blood pressure. Interestingly,

A dual specificity protein phosphatase and redox homeostasis in plants

Man has been struggling to understand and define life since the day he became aware of it. Innumerable philosophies and findings over the history of mankind together draw the perspective with which we look at life today.

How to optimize pneumonia treatment for the elderly

Can you tell the age of this patient with pneumonia by looking at her chest X-ray (Fig. 1)? Neither can the germ infecting her. And yet there are unique aspects of treatment to know if the patient

Excess weight reduction in primary school students

Childhood obesity is a global public health problem related to many preventable diseases, alarmingly on the increase. Iran is no exception. In an effort to address this problem, we designed and tested an intervention to combat excess

Mindless monitoring: When does attention help or hurt our emotional health

When it comes to anxiety and depression, a long-standing assumption is that there is something off about one’s ability to effectively focus and attend to present moment situations. Prominent theories in clinical psychology propose that anxiety causes

Mechanistic analysis of antimicrobial peptide membrane interactions by molecular dynamics simulation

The world emergence of the bacterial superbugs has limited the effectiveness of the available antibiotics in the clinic. Because of the multifaceted antimicrobial mechanism of actions, cationic antimicrobial peptides (AMPs) may be considered as promising molecules to

Understanding how liposome composition and manufacturing affect docetaxel encapsulation and cell killing

Docetaxel (DTX) belongs to a class of anticancer drugs clinically used to treat a plethora of cancers, including breast and prostate cancer. DTX works by interfering with the cell cycle and blocking cell proliferation. Although being a

A culturally adapted lifestyle intervention among Middle-Eastern immigrants in Sweden

In Sweden, there is an increasing immigrant population of which a large proportion originate from the Middle East. Middle East is one of the areas with highest diabetes prevalence in the world. Middle-Eastern immigrants in Sweden have

Bioinformatics at the cutting EDGE: Empowering the Development of Genomics Expertise

An in-depth understanding of how microorganisms function is required to address many challenging issues facing society today such as understanding how to eradicate infectious diseases and mitigate climate change. Answers are held in their genetic code. Advancements