Category Archives: Research

The eye gets stronger after seeing the world in chaos

Resembling the fact that some people are left-handed while some are right-handed, our two eyes are not functioning equally. Usually, our brain has a preference to the input signals from one of the two eyes, which is

A novel PET radiotracer for molecular imaging of the α3β4 nicotinic acetylcholine receptor

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels that mediate fast synaptic transmission in the brain. These receptors are homo- or hetero-pentameric combinations of the α and the β subunits which each subtypes

What it takes to survive a transplant

Many patients with blood cancers, such as multiple myeloma, leukemia, or lymphoma, have radiation treatment or chemotherapy to destroy their tumor cells and diseased bone marrow. Unfortunately the treatment damages their immune system leaving them immunocompromised. To

Overproduction of membrane-integral undecaprenyl pyrophosphate phosphatase from Vibrio vulnificus

In the cytoplasm, undecaprenyl pyrophosphate (C55-PP) is synthesized by undecaprenyl pyrophosphate synthase (UppS) through consecutive condensation reactions of eight molecules of isopentenyl pyrophosphate (Ipp) with farnesyl pyrophosphate (Fpp). The product C55-PP is then dephosphorylated to monophosphate undecaprenyl phosphate

RKIP and YY1: The ‘good’ and the ‘bad’ shields in the protection of cancer spreading and resistance to therapies

Cancer originates from all of the uncorrected mutations occurring in the DNA of the cell that lead to abnormal cell growth. Accordingly, the accumulation of these mutations transforms a normal cell into an “immortal” cancer cell with

Mind-wandering plus mindfulness: say ‘no’ to negative mood or depression

Mind wandering and its equivalent concepts such as self-generated thought, stimulus independent thought, task-unrelated thought, and spontaneous thought refer to a mental phenomenon that occupies considerable time in everyday life. The high frequency of the occurrence of

The aptamer BC007: for the treatment of “functional autoantibody diseases”. First developed for patients with dilated cardiomyopathy

Autoimmunity is accepted as the origin or amplifier of various diseases. In the mid-1970s, a new class of “so-called” functional autoantibodies that bind to G-protein-coupled receptors (GPCR-AABs) was identified for downstream pathologies. The related “functional autoantibody diseases”

Chagas disease a neglected ills without treatment

Chagas disease (CD) is transmitted by the parasite Trypanosoma cruzi, and was discovered in 1909 by the Brazilian medical doctor named Carlos Chagas. Until today, CD remains a serious public health problem, with more than 7 million

Trace metal contamination in the surface sediment of south east coast of India

Sediments are the most important reservoir of trace metals, thus, serve as vital indicator to intercept the mechanism of transportation and accumulation of trace metals in the coastal environment. Sediment texture, mineralogical composition and physical transformation influence

Mitochondrial gene discontinuity that translates into fragmented functional proteins

The majority of protein-coding genes in nuclear genomes are interrupted by spliceosomal introns or, less often, by inteins. These intervening sequences are spliced at the RNA or protein level, respectively, so that intact proteins become reconstituted. In

Bacterial melanin in dark-colored sponges: Ecological significance and biomedical applications

Sponges are second dominant to corals in terms of biomass in many coral reef ecosystems. They play a significant role in maintaining the health of reef ecosystems through processing of waste generated in the system by continuous

Antithrombotic therapy duration after coronary stenting: finding the sweet-spot with a novel clinical risk score

Coronary atherosclerosis is still the principal cause of morbidity and mortality in western countries, by inducing ischemia or infarction of the myocardium. Percutaneous treatment of atherosclerotic lesions is nowadays the most common form of treatment of such

Are moths as old as dinos?

The larvae of moths have eight pairs of legs. The moth family Geometridae is specific in that their larvae have five pairs of legs and move by looping: “looper moths”. One of geometrid subfamilies, Geometrinae, has green

How does phenobarbital, a therapeutic sedative, activate a nuclear receptor through phosphorylation?

Steroid hormones activate a family of nuclear proteins called nuclear receptors to regulate every aspect of human physiology, reproduction, development, differentiation, metabolism and immunity. A nuclear receptor molecule is comprised of two major structural domains; DNA-binding (DBD)

mRNA decay activity in neurons regulates survival of worms at high temperatures

The ability of an organism to quickly alter or fine-tune its gene expression profile as a response to unfavorable and stressful conditions is a vital trait that can determine its chances of growth and survival in unstable

Sole Pheromones: “What we have here is a failure to communicate”?

Pheromones are an important, but understudied, facet of reproduction in many animals. What we know about pheromones in fish mostly comes from freshwater species. However, many economically important species are marine. One such is the Senegalese sole