Lipid metabolism involves a wide range of processes in which lipids are processed and used as energy sources, signaling molecules and structural elements of cells. Given its importance, dysfunctions in lipid metabolism, both small and large, can have significant negative effects for the body. In line, there is a wide range of lipid disorders and diseases which increase the risk of developing fatal diseases such as liver and cardiovascular disease and cancer. Importantly, due to the rise of the so-called Western lifestyle, characterized by excessive caloric consumption and low energy expenditure, an alarming and increasing number of people develop lipid-associated disorders and metabolic diseases. As such, it is now more important than ever to develop effective strategies to prevent and treat metabolic diseases.

Among other events, increased production of oxidized low-density lipoproteins (oxLDL) is emerging as an important bridge between lipid metabolism dysfunction and development of metabolic diseases. After meals, the liver processes and packages a variety of lipids as LDL particles, which it then sends into the circulation so that these lipids can be delivered to other tissues and organs for their use. In patients with lipid disorders and metabolic diseases, disturbed cell function leads to inflammation and oxidative stress, leading to the modification of a variety of molecules, including the conversion of LDL into oxLDL. Unlike LDL, the uptake of oxLDL by cells leads to further cellular dysfunction, inflammation and oxidative stress, exacerbating a pathogenic vicious cycle that can both trigger and worsen metabolic diseases. Previously, researchers showed that by injecting mice with inactivated S. pneumoniae, a bacterium known for inducing lung and brain disease, they can induce the production of antibodies against phosphorylcholine (PC), a component of S. pneumoniae and of oxLDL. By increasing antibody levels against PC, researchers were able to increase the clearance of oxLDL and improve disease severity in animal models for atherosclerosis, non-alcoholic liver disease and Niemann-Pick disease, suggesting that pneumococcal immunization is a promising tool to target oxLDL.

In order to analyze whether pneumococcal vaccine also increases antibodies against PC and/or oxLDL in humans, we conducted a pilot clinical trial in patients with metabolic diseases characterized by lipid metabolism dysfunction, inflammation and oxidative stress, namely patients with familial hypercholesterolemia, partial lipodystrophy and Niemann-Pick disease. Four weeks after receiving one dose of Prevenar 13, a pneumococcal vaccine commonly used in the clinic, we did not observe an increase in patients’ antibody levels against PC and/or oxLDL. While larger studies are necessary to confirm our findings, our results suggest that a single dose of Prevenar 13 is not suitable to increase antibodies against PC and/or oxLDL. As such, further research is required to develop efficient immunization strategies to target oxLDL in humans.

Ronit Shiri-Sverdlov, Inês Magro dos Reis, Tom Houben
Department of Genetics and Cell Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, The Netherlands

Publication

The Influence of a Conjugated Pneumococcal Vaccination on Plasma Antibody Levels against Oxidized Low-Density Lipoprotein in Metabolic Disease Patients: A Single-Arm Pilot Clinical Trial
Ronit Shiri-Sverdlov, Inês Magro Dos Reis, Yvonne Oligschlaeger, Tim Hendrikx, Dennis M Meesters, Annick Vanclooster, Nele Vanhoutvin, Ger H Koek, Marit Westerterp, Christoph J Binder, David Cassiman, Tom Houben
Antioxidants (Basel). 2021 Jan 18

Read offline:     

Related Articles:

	Excessive postprandial VLDL remnants in plasma cause… Remnant lipoproteins (RLP) are the TG-rich lipoproteins metabolized by lipoprotein lipase (LPL) and increase in plasma after fat intake (Fig. 1), parallel with the increase of plasma triglycerides (TG). We…
	Celiac disease and liver disorders Immunologically mediated liver diseases belong to the common extraintestinal manifestations of celiac disease. In celiac disease, increased intestinal permeability is thought to be an early feature in the pathogenesis. Dietary…
	More Paleolithic-like lifestyles and diets… Colorectal cancer (CRC) is the second leading cause of cancer deaths among women and men combined in the United States. CRC incidence (i.e., the rate of new diagnoses) varies about…
	Vaccine design in the OMICs Era A retrospection into the field of vaccinology reveals the triumph of medical science over infectious diseases that were once a death sentence. Research on vaccines has come a long way…
	How alcohol consumption might contribute to viral… The coexistence between excessive alcohol consumption and hepatitis C virus (HCV) infection is causative of a high death ratio annually. It is well-known that phosphoinositides (PI) not only regulate a…
	Heat, diet and lifestyles control longevity in… The inactivation of the heat shock gene called Sirtuin 1 (Sirt 1) is associated with many chronic diseases such as diabetes, non alcoholic fatty liver disease (NAFLD), cardiovascular disease and…