Safety of quinlones reviewed by FDA
The fluoroquinolone antibiotics are a commonly prescribed group of agents which includes ciprofloxacin, levofloxacin and moxifloxacin. They are used in a wide range of infections. Late last year FDA convened an Advisory Committee to review the information to assess the benefit or risks of these drugs in relatively simple, but still very troublesome, infections like sinusitis, chronic bronchitis and cystitis. The discussion focused on a constellation or collection of adverse events, cardiac issues, neuropathy problems and tendon, which are already seen with these antibiotics. This collection of adverse events was proposed to be a new syndrome FluoroQuinolone Associated Disability, FQAD. The Committee members were not convinced about this syndrome but did recommend against broad based use of fluoroquinolones in these infections due to the potential risk of side effects. As well the Committee wanted better education of doctors on how to use antibiotics better to preserve this critical group of drugs. Broad discussion highlighted the overall safety issues associated fluoroquinolones in community infections. As with all antibiotics careful prescribing is strongly recommendation so we maintain these valuable drugs.
GST Micro LLC, Downingtown, PA 19335, USA
FDA and the safe and appropriate antibiotic use of fluoroquinolones.
Lancet Infect Dis. 2016 Mar