Tag Archives: aging
Historical stability of the human aging rate and its decline in our time
Using age-related mortality data for 40 countries, it is shown that the rate of aging does not change significantly over history and is almost the same for different countries from the mid-18th to the mid-20th century. However,
Reprogramming skin into brain to study aging and age-related brain diseases
“Inevitable as the passing of time” is a common phrase and a simple truth; in our lives, we may have impactful experiences, grow and learn but, inescapably, we age. It is clear that as we age, our
FTIR spectroscopy and ımaging to understand donor age effect on bone marrow mesenchymal stem cells
Stem cells, like Bone Marrow Mesenchymal Stem Cells (MSCs), have enormous potential to develop new therapies for tissue regeneration and repair with their ability to differentiate into many different types of cells. The aging process and the
Unsightly war zones of aging
Imagine you were trying to hammer a nail, but instead you accidentally hit your thumb. Aside from pain, you may notice redness, swelling, and warmth of your thumb. These are symptoms of inflammation. When an area of
Why iron and copper may be harmful to the aging brain
Similar to other organs, brain function declines with age. Furthermore, age is the single greatest risk factor for Alzheimer’s disease as well as other neurodegenerative diseases. Both iron and copper increase in the brain with aging and
The protein “CHIP” unfurls anti-aging activity
Researchers at the universities of Cologne and Bonn uncover the link between protein aggregation and aging. Not only does our way of life determine how long we live but so too does our genetic material. Of particular
Atomic structures of telomerase shed light into the mechanism of telomere replication
Telomeres comprise the six nucleotide repeats at the end of eukaryotic chromosomes and they are essential for the faithful replication and protection of our genome. Significant telomere attrition forces the cells to enter a dormant state to
A new chance for rapamycin
Rapamycin is a bacterially-produced drug first discovered in the soil of Easter Island, and currently used as an immunosuppressant for organ transplantation and the treatment of certain types of cancer. Rapamycin has received popular attention following the
Aorta tertiary lymphoid organs: Powerhouses of B cell immunity in atherosclerosis
Cardiovascular disease (CVD) is the leading cause of death worldwide. Yet, our understanding of how the immune system impacts CVD is very limited and immune system-based therapeutic approaches are not in sight. Lymphocytes are major cellular constituents
β-Carotene requirement for anti-aging depends on genetic background
Cellular telomere, a region of repetitive nucleotide sequences of TTAGGG, resides on both ends of chromosomes and its length is shortened by reflecting the replication number of chromosomal DNA, accordingly, telomere length is the most reliable indicator
Benefits of aging?
Does pain increase or decrease with age, and if so, what causes the change? A factor we considered is that sensitivity to pain could be altered by an age-related loss of neurons involved in regulation of affective/emotional
A new drug target for healthful aging
With the aging population of the United States increasing every year, there is an increasing need to develop new therapeutic modalities to provide for healthful aging. Although longevity is generally considered positively in most families, and of
Is surgical treatment effective for different forms of spinal cord compression?
Degenerative Cervical Myelopathy (DCM) is the most common cause of injury to the spinal cord in the elderly population worldwide and, with an aging population globally, it is likely to become even more common. As such, a
Fruit flies become disabled prior to death
Disability among the elderly costs the U. S. healthcare systems billions of dollars each year. Much of this cost is experienced in the months and years before death. While it is clear we cannot avoid death, perhaps
Aging is adaptive
Aging is a lifecycle stage common to all life forms and is observed in both unicellular and multicellular organisms. The primary manifestation of aging in unicellular organisms is replicative senescence. As the cell ages, cell cycles become
Age-dependent impairments in spatial learning in mice with reduced BDNF levels
The protein BDNF (brain-derived neurotrophic factor) belongs to the family of nerve growth factors (neurotrophins). Therefore, one of its major functions is related to the maturation and differentiation of developing nerve cells in the brain. But BDNF
Multiminerals in mammals: longevity, organ biology and other things
Whenever we pick up a bottle of multimineral supplement, some chemical elements often appear on the list of ingredients: sodium, potassium, calcium, magnesium, zinc, iron, and so on. How are they important to us? Well, our bones
Overcoming aging-caused difficulties in salivary gland
Stem cells are the cells that are responsible for the maintenance of tissues and organs by replacing functional cells with a limited life-span or that are damaged beyond repair. Over the last decades stem cells have been
A promising new drug treatment for Alzheimer’s disease
Diabetes is a risk factor for developing Alzheimer’s disease (AD). The underlying mechanism seems to be that insulin signaling in the brain of patients with AD is very much impaired. Insulin not only controls blood sugar levels,
Access to a car can be important for the health and mental health of older people with impaired mobility
This research looked at statistical relationships between access to a car and the self-reported health and mental health of people aged 65years or older, living in Northern Ireland. The analysis used the Northern Ireland Longitudinal Study (NILS),
