Tag Archives: Alzheimer disease

Linking copper, tyrosines and protein aggregation in Alzheimer’s disease

The prevalence of Alzheimer’s disease (AD), the most common cause of dementia nowadays, is expected to increase within the coming years, representing a serious threat for society and the healthcare system. For this reason, a lot of

Deep Molecular Profiling to understand the biology of Alzheimer disease

AoS. Deep Molecular Profiling to understand the biology of Alzheimer disease

Alzheimer disease (AD) is a complex, polygenic disease with genetic, cellular, pathologic, and clinical heterogeneity. Advances in high-throughput sequencing and omics technologies have accelerated the drive toward personalized medicine. Human bio-specimens using these high-throughput platforms have emerged

The use of olfactory neuronal precursors for antemortem Alzheimer’s Disease diagnosis

Alzheimer’s disease (AD) is a disabling and progressive illness that causes a high social cost and economic burden. Current diagnosis has been done by clinical appreciation based on the Diagnostic and Statistical Manual of Mental Disorders (DSM–5) and

The suitability of scopolamine as an Alzheimer’s model

AoS.The suitability of scopolamine as an Alzheimer’s model

Alzheimer’s disease is the most common cause of dementia. About 50 million people worldwide have Alzheimer’s disease or a related form of dementia. Alzheimer’s disease is a terminal illness affecting mostly the elderly above the age of

A mass spectrometry view of the interaction of Alzheimer’s disease proteins with an anti-aggregation compound

Alzheimer’s disease is a neurodegenerative disease that has been studied extensively over the last four decades. Millions of people worldwide are affected by this disease, and because our population is growing older, this disease is becoming alarmingly

Biomarkers for Alzheimer’s disease diagnosis: an eye on retinal inflammation

Biomarkers for Alzheimer’s disease diagnosis. AoS

Alzheimer’s disease is one of the most common neurodegenerative disorders. Alzheimer’s disease cases are constantly increasing worldwide due to population aging. Typical symptoms of the disease include memory loss, cognitive deficits, personality and behavior modifications. At the

Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease

Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease

Dementia, which is characterized by decline of memory or other cognitive traits to the extent that a person’s daily functioning is affected, is one of the most important global health challenges of our time. Approximately 50 million

Cholesterol manipulation switches the production of “toxic Aβ” to “protective Aβ”

The amyloid hypothesis maintains that the pathogenesis of Alzheimer’s disease (AD) is driven by the production and accumulation of amyloid-β (Aβ) peptides in the brain. Consequently, many therapeutic strategies to reduce Aβ production have been examined. However,

Alzheimer’s risk gene weakens brain cell’s garbage disposal system

APOE ε4 is the most common genetic risk factor for development of Alzheimer’s disease. Having two copies of this gene (one from the mother and one from the father) increases a person’s relative risk to as much

Novel perspectives for the Alzheimer´s disease therapy in a multitargeted approach

Alzheimer´s disease (AD) is the most wide-spread neurodegenerative disease and develops to a main problem for a society in which the people get older and older as a result of improved drug developments and therapies. The benefit