Tag Archives: Alzheimer
Deep Molecular Profiling to understand the biology of Alzheimer disease
Alzheimer disease (AD) is a complex, polygenic disease with genetic, cellular, pathologic, and clinical heterogeneity. Advances in high-throughput sequencing and omics technologies have accelerated the drive toward personalized medicine. Human bio-specimens using these high-throughput platforms have emerged
The use of olfactory neuronal precursors for antemortem Alzheimer’s Disease diagnosis
Alzheimer’s disease (AD) is a disabling and progressive illness that causes a high social cost and economic burden. Current diagnosis has been done by clinical appreciation based on the Diagnostic and Statistical Manual of Mental Disorders (DSM–5) and
The suitability of scopolamine as an Alzheimer’s model
Alzheimer’s disease is the most common cause of dementia. About 50 million people worldwide have Alzheimer’s disease or a related form of dementia. Alzheimer’s disease is a terminal illness affecting mostly the elderly above the age of
Physiological brainwashing
There is a barrier in the brain, known as the blood-brain barrier, which strictly regulates the exchange of substances between the blood and this organ. The blood-brain barrier restricts the passage of drugs into the brain and
Most common behavioral problems in people with dementia
With people all over the world living longer, more and more of them develop problems with brain functions. Some of these problems are mild, e.g. slight forgetfulness, but some may interfere with their daily activities, such as
A mass spectrometry view of the interaction of Alzheimer’s disease proteins with an anti-aggregation compound
Alzheimer’s disease is a neurodegenerative disease that has been studied extensively over the last four decades. Millions of people worldwide are affected by this disease, and because our population is growing older, this disease is becoming alarmingly
Biomarkers for Alzheimer’s disease diagnosis: an eye on retinal inflammation
Alzheimer’s disease is one of the most common neurodegenerative disorders. Alzheimer’s disease cases are constantly increasing worldwide due to population aging. Typical symptoms of the disease include memory loss, cognitive deficits, personality and behavior modifications. At the
Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease
Dementia, which is characterized by decline of memory or other cognitive traits to the extent that a person’s daily functioning is affected, is one of the most important global health challenges of our time. Approximately 50 million
Novel perspectives for the Alzheimer´s disease therapy in a multitargeted approach
Alzheimer´s disease (AD) is the most wide-spread neurodegenerative disease and develops to a main problem for a society in which the people get older and older as a result of improved drug developments and therapies. The benefit
DNAJB6 – an early-stage scavenger of amyloidogenic peptides
A molecular chaperone has been discovered that binds to amyloidogenic peptides and delays onset of aggregation and neurodegeneration. Chaperone proteins, existing in the cells of all organisms, are helper proteins that serve to keep the proteins in
Mutations in the SORL1 gene affect risk of early-onset Alzheimer’s disease
Alzheimer’s disease (AD) is the most common cause of dementia, leading to an enormous burden on societies worldwide. In brains of patients with AD, abnormal tangles of a protein called tau are found within nerve cells, in
Comparison of the effect of exercise on late-phase LTP of the dentate gyrus and CA1 of Alzheimer’s disease model
There has been a recent upsurge of scientific reports about the benefits of regular physical exercise for general health and particularly for mental health. Healthy diet and physical activity have emerged as promising low-cost measures for protection
The potential of chitosan in prevention and treatment of age-related diseases
According to the recent report of The Department of Economic and Social Affairs of the United Nations Secretariat the number of elderly (aged 60 years or over) is expected to increase from 841 million people in 2013
