Tag Archives: alzheimer’s disease
Why iron and copper may be harmful to the aging brain
Similar to other organs, brain function declines with age. Furthermore, age is the single greatest risk factor for Alzheimer’s disease as well as other neurodegenerative diseases. Both iron and copper increase in the brain with aging and
Acting in mechanisms of aging to delay/prevent Alzheimer’s disease
Alzheimer’s disease (AD), a severely debilitating and ultimately fatal brain disorder, affects millions worldwide. To date, clinical efforts to find a cure or adequate treatment have met with dispiriting failure. The disease is now on an ominous
Reversibility of Aβ oligomer neurotoxicity: Insights into the treatment of Alzheimer’s disease
Alzheimer’s disease (AD), the most common neurodegenerative dementia disorder, causes memory impairment and other cognitive deficits. AD is neuropathologically characterized by senile plaques and neurofibrillary tangles, which are composed of amyloid β-protein (Aβ) and phosphorylated tau proteins,
Intrinsic human multidrug transporters as helpers against Alzheimer’s Disease
The cause(s) of Alzheimer’s Disease (AD) is still unknown, so is a proper method for diagnosis. AD is a widely occurring form of neurodegeneration that is considered to affect 47 million people worldwide, according to the World
Determination of regions involved in amyloid fibril formation for Aβ(1-40) peptide
Mechanisms of amyloid formation of Aβ peptide are studied intensively. Determination of regions responsible for aggregation of the peptide and formation of amyloid fibrils is one of the primary aims in studying the formation of such structures.
Conformal invariants for landmark curve based brain morphometry analysis
Abnormal structural changes measured on cortical surfaces are important biomarkers for Alzheimer’s disease (AD). In brain imaging research, landmark curves are usually delineated on cortical surfaces to represent significant sulcus and gyrus patterns. Landmark curves are widely
Adolescent exposure of MDMA potentiates one of the hallmarks of Alzheimer’s disease
3,4 Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative widely consumed by adolescents, which has been described that produces oxidative stress in neurons such as dopaminergic neurons. Moreover, many patients with Alzheimer’s disease develop extrapyramidal symptoms due to alterations
Determination of the size of folding nuclei of fibrils formed from Aβ(1-40) peptide
One of the most important models for studying amyloid fibril formation is the Aβ peptide, aggregates of which form plaques in the course of Alzheimer`s disease. Formation of Aβ aggregates goes through the nucleation mechanism with exponential
Amyloid specific antibodies are not necessary to detect amyloid plaques in Alzheimer’s disease
Alzheimer’s disease (AD) is an age-related neurological disorder which impairs learning, memory, and cognition. Gradual accumulation of amyloid beta protein (Aβ) is one of the hallmark pathologies of this disease. Early detection of the presence of Aβ
Eat your carrots – otherwise your risk of getting Alzheimer’s might increase!
Vitamin A is an important component of human nutrition, delivered by e.g. liver or fish dishes, but also fruits and vegetables, such as carrots. It is not only needed for development of organs and tissue (e.g. the
Chromosome gains and losses in the human brain are probably less important than previously thought
In general, each human cell contains 46 chromosomes: 23 chromosomes from each parent. Before a cell divides all chromosomes are duplicated. The cell has several mechanisms to ensure that during cell division the chromosomes are evenly distributed
A new trehalose-conjugated peptide protects neurons from Aβ’s oligomers insult
Alzheimer’s disease (AD) is by far the most common cause of dementia affecting more than 35 million people worldwide. AD is characterized by memory loss, dramatic impairment of cognitive skills, and progressive body and mind decline ultimately
Management of apathy in the long-term care setting
Management of apathy is a very important issue in the long-term care because many residents with neurodegenerative disorders suffer from this syndrome. In Alzheimer’s disease, apathy is the most common behavioral syndrome and may occur already in
Trapping copper with peptides to diminish metal-related toxicity in Alzheimer’s disease
Metals are essential in many life processes and, as such, all organisms including our body have developed mechanisms for their uptake and tight regulation to achieve a normal functioning. Failure of these mechanisms is reflected in the
Early-onset Alzheimer disease: what are we missing?
Memory is the first brain function that starts to fade away when Alzheimer disease (AD) pathology affects the brain of a patient. Decline of additional cognitive functions, shortly follows. This progressive and irreversible disease, intrudes the life
Mutations in the SORL1 gene affect risk of early-onset Alzheimer’s disease
Alzheimer’s disease (AD) is the most common cause of dementia, leading to an enormous burden on societies worldwide. In brains of patients with AD, abnormal tangles of a protein called tau are found within nerve cells, in
Regional Alzheimer’s disease research
According to World Alzheimer Report 2015, over 46 million people live with dementia worldwide. The incidence of dementia is estimated over 9.9 million every year, and nearly half of new dementia cases (4.9 million) occurred in Asia.
One of the mechanisms of amyloid fibrils formation based on the sizes of folding nuclei of Aβ40 and Aβ42
Antibiotics and various advances in medical treatment have led to overall growth of life expectancy. However, along with positive aspects of prolonged life, humanity has faced a new challenge – age-related deceases. Parkinson’s disease along with Alzheimer’s
Differential courses of delay discounting in mild cognitive impairment and Alzheimer´s disease
People prefer to receive a reward rather sooner than later, which means that people put a smaller value on a reward they have to wait for (= delay discounting, DD). But when people get to choose between
