Tag Archives: alzheimer’s

Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease

Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease

Dementia, which is characterized by decline of memory or other cognitive traits to the extent that a person’s daily functioning is affected, is one of the most important global health challenges of our time. Approximately 50 million

Cholesterol manipulation switches the production of “toxic Aβ” to “protective Aβ”

The amyloid hypothesis maintains that the pathogenesis of Alzheimer’s disease (AD) is driven by the production and accumulation of amyloid-β (Aβ) peptides in the brain. Consequently, many therapeutic strategies to reduce Aβ production have been examined. However,

Alzheimer’s risk gene weakens brain cell’s garbage disposal system

APOE ε4 is the most common genetic risk factor for development of Alzheimer’s disease. Having two copies of this gene (one from the mother and one from the father) increases a person’s relative risk to as much

Understanding vaccine development – Lessons to make effective vaccines against Alzheimer’s disease

A natural protective immunity against a disease usually anticipates the successful development of preventive vaccines; as shown by the infectious diseases and lately cancer vaccines. Currently available information shows that the immune system is since an early

Conformal invariants for landmark curve based brain morphometry analysis

Abnormal structural changes measured on cortical surfaces are important biomarkers for Alzheimer’s disease (AD). In brain imaging research, landmark curves are usually delineated on cortical surfaces to represent significant sulcus and gyrus patterns. Landmark curves are widely

Novel perspectives for the Alzheimer´s disease therapy in a multitargeted approach

Alzheimer´s disease (AD) is the most wide-spread neurodegenerative disease and develops to a main problem for a society in which the people get older and older as a result of improved drug developments and therapies. The benefit

Lipids are major players in Alzheimer’s disease

Alzheimer’s disease is the most common neurodegenerative disorder affecting over 36 million people worldwide. Alzheimer’s patients suffer from dementia and memory loss and go through a progressive, irreversible and eventually fatal loss of cognitive functions. When Alois

Resting state fMRI analysis using sparse dictionary learning in SPM framework

Brain always be active even people are in rest. In the resting period, it has been observed that particular groups of brain region are always co-activated. These regions are functionally connected each other and each group is

A possible new treatment for Alzheimer’s disease and stroke using nanoparticles

Alzheimer’s disease (AD) and stroke are two neurological disorders that share the common feature of neuronal death. The peptide under investigation here is IRL-1620, which has been shown in previous studies to reverse neuronal death as well

Promote the health of dementia caregivers

The vast majority of the care for people with Alzheimer’s dementia is and will be carried out by informal caregivers as health care services across the world cut funding. This is a major concern in an aging

Sex, salt, and the central nervous system: estrogen and body sodium balance

Historically, research about reproductive hormones like estrogen has focused on reproduction and reproductive behaviors. Certainly, this focus is understandable; however, it is becoming increasingly obvious that estrogen plays a broader role . In fact , estrogen profoundly

A promising new drug treatment for Alzheimer’s disease

Diabetes is a risk factor for developing Alzheimer’s disease (AD). The underlying mechanism seems to be that insulin signaling in the brain of patients with AD is very much impaired. Insulin not only controls blood sugar levels,

A rare variant in TREM2 increases risk for late-onset Alzheimer’s disease

Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia and affects over 5 million Americans. This neurodegenerative disease results from a combination of genetic and environmental effects and currently has no effective cures, treatments, or

A small structure hidden in the brain that might play a big role in diseases like depression and autism

The choroid plexus is a hidden and often neglected, but important, structure in the brain. The choroid plexus hangs inside the brain ventricles which are filled with cerebrospinal fluid (CSF) (Fig. 1). Importantly, the choroid plexus is

New effective treatments for Alzheimer and Parkinson’s disease

Alzheimer and Parkinson’s disease are the most common neurodegenerative disorders. As people are getting older than in previous generations, the number of people who are affected has increased. Unfortunately, there is no cure for these diseases. The

Another beneficial role for insulin in the brain: keeping the brain immune responses in check

Brain disease is an umbrella term, which is used to describe a broad variety of diseases ranging from epilepsy to Alzheimer’s disease to multiple sclerosis and everything in between. Brain diseases differ from each other at the

Memory mechanism demonstrated in humans

Long-term potentiation (LTP) is the pricipal candidate synaptic mechanism underlying learning and memory. LTP has been studied extensively in laboratory animals, but until recently, inquiry into the functional significance of LTP has been hindered by the absence

Employment of migrant care workers by Italian families assisting older Alzheimer’s disease patients

A rising phenomenon across the European Union (EU) is the increasing presence of migrant care workers (MCWs), privately employed by families of older people in need, who take over different tasks: supervision, drug administration, support in mobility

Chaperones’ seduction

Molecular chaperones are a very special class of proteins found in all organisms from bacteria to humans. Like their name suggests, they accompany and supervise the correct folding of all the other proteins in cells. This process

A link between reduced blood oxygenation and failure in learning and memory in a mouse model of Down syndrome

Down Syndrome (DS) is the most frequent genetic cause of cognitive disability in humans, affecting more than 6 million people worldwide. Triplication of more than 300 genes on chromosome 21 results in gene dosage imbalance that affects