Tag Archives: amyloid fibril
There are different ways by which small molecules interact with protein and its aggregates. One of it is synergistic interaction of drugs or small molecules against protein aggregates. Protein aggregation is a common cause of neurodegeneration. Most
The misfolding and subsequent aggregation into β-sheet rich assemblies of endogenous polypeptides, such as β-amyloid peptide, tau protein, α-synuclein, and insulin are the underlying causes of diabetes and many neurodegenerative diseases. Although, no sequence or structural similarity
Mechanisms of amyloid formation of Aβ peptide are studied intensively. Determination of regions responsible for aggregation of the peptide and formation of amyloid fibrils is one of the primary aims in studying the formation of such structures.