Tag Archives: angiogenesis

Lernaean hydra puzzle in compensatory angiogenesis and tumor drug resistance

Diagrammatic representation of how compensatory angiogenic mechanisms are driven by redendent proangiogenic signalling

Before we proceed to apply the analogy of Lernaean hydra to compensatory angiogenesis and tumor drug resistance against anti-angiogenic drugs (AADs), let us have a cursory look at the interesting mythology of this hydra. According to Greek

Blood vessels regulate fetal brain growth

Millions of neurons are generated during fetal development from progenitor cells that reside inside the embryonic brain. These neural progenitor cell (NPC)s divide many times to generate new neurons in a process termed ‘neurogenesis’. At each cell

A newly identified protein controls endothelial barrier function by acting as a cellular glue

The endothelial barrier function maintains vascular and tissue homeostasis, and therefore modulates many cardinal physiological processes such as angiogenesis, immune responses, and dynamic fluid exchanges throughout organs. Blood vessels rely on endothelial cell-cell adhesion to generate a

Cancer and blood vessels: an old ridlle resolved

As any other organ of the human body, cancer needs a blood supply to provide oxygen and nutrients and to eliminate wastes.  Although already the ancient Greeks had realized that there is a close relationship between tumours

Prox-1 and adipogenesis

Adipogenesis is the biological process that controls adipocytes differentiation and is one of the most well studied models of cellular differentiation. Adipose tissue is involved in the control of energy balance and especially in the study of

Heat shock protein as a novel druggable target in angiogenesis?

Angiogenesis is a physiological process that involves formation of new blood vessels from pre-existing vessels for efficiently providing oxygen and nutrients during growth and development, as well as during wound healing. Under pathological conditions, angiogenesis is regulated

Silencing a microRNA may keep the doctor away for diabetic wounds

Patients with diabetes are frequently afflicted with impaired wound healing that may progress into chronic, diabetic ulcers, often leading to complications including limb amputation with increased risk of morbidity and mortality. These ulcers occur not only in

Imaging tumor development using next generation raster scan optoacoustic mesoscopy

Cancer is one of the major diseases in the 21st century. Hundreds of billions of dollars have been spent on cancer research in the last half century, but still, our understanding of the disease mechanisms is limited.

Demyelination and remyelination signalling in multiple sclerosis as an aid to targeted therapy

Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS) characterised by demyelination. Demyelination, i.e. damage and erosion of the myelin sheath which protects the nerve fibres, occurs in the white matter of

New function for the well-known lipids

Angiogenesis is the new blood vessels formation in adult tissues which share some similarities to growth of blood vessels during development called vasculogenesis. It is estimated that growth of any tissue to the sizes above 2-3 mm3

Metabolism and pheochromocytoma/paraganglioma

Tumors are named according to the organ or the tissue whose cells undergo biological derangement causing the loss of the control mechanisms that normally limit cell growth. Therefore, breast tumors derives from the cells of the ducts of

Topical administration of an antimicrobial peptide as a new strategy for improved burn wound healing

Burn wounds represent a major global concern, as more than 100 million people worldwide are estimated to experience burn injuries every year. These may be caused upon exposure to heat, radiation, chemicals or electric shocks, often resulting