Tag Archives: antibiotic
Carbapenem-resistant Enterobacteriaceae: fighting mutants
Antibiotic resistance occurs when bacteria causing an infection survive after being exposed to a drug that, under normal conditions, would kill it or inhibit its growth. As a result, this surviving strains multiply and spread due to
Antibiotic tolerance in bacteria: how to regain susceptibility?
Bacteria use a plethora of mechanisms to evade killing by antibiotics. Resistance is the best documented mechanism. Here, genetic changes in the bacterial DNA result in antibiotic insensitivity. As a consequence, resistant bacteria are able to grow
High potential polymer carriers to enhance antibiotic efficiency in bacterial biofilms
Cystic fibrosis (CF) is a frequent genetic disease resulting in chronic and difficult-to-treat pulmonary infections and inflammation that needs a lifelong treatment with aggressive antibiotic therapy by oral, intravenous or inhaled routes. The most abundant bacterial species
The nature of bel-1 attC stabilizes its genetic environment and contributes to antibiotic resistance spreading
The rapid emergence of antibiotic resistance is a worldwide crisis, endangering the efficacy of antibiotic treatment. Multidrug resistance in Gram negatives is now recognized as an issue of worldwide interest. Those bacteria possess various resistance mechanisms compromising
A culture medium for screening pandrug- resistance to aminoglycosides in Gram-negative bacteria
Multidrug resistance in Gram negatives is now recognized as an issue of worldwide interest. Those bacteria possess various resistance mechanisms compromising the efficacy of several class of antibiotics such as beta-lactams and aminoglycosides. Therefore, it is essential
Counting choline: why this nutrient is important and how we can measure it
Choline is an important nutrient for the growth and sustenance of living things, from humans to bacteria. Cells covert choline into phosphocholine via the activity of the enzyme choline kinase, and a change of other enzyme mediated
Phage therapy: a one-hundred-year-old alternative to modern, chemical antibiotics
Phage therapy is the use of bacterial viruses, known as bacteriophages, or phages, to control or eliminate problematic bacteria (Fig. 1). Targeted bacteria can range from biofouling agents to agricultural pests to human pathogens, etc. As has
Simple mathematical formulas for tracking the number of antibiotic resistance cases globally
In order to continue to live, microbes and germs have found ways to prevent drugs from killing them in the process of curing patients—when the patients ingest the drugs for treatment. Microbes destroying drugs within patients and
Artilysin®s as a novel enzyme-based approach to kill drug-resistant bacteria
In recent years world leading health care authorities have warned the global community about the threat of antimicrobial resistance. We risk being cast back into the dark ages when minor infections and injuries were often lethal. However,
Are disinfection processes an effective barrier in controlling the spread of antibiotic resistance in the environment?
According to the report on global surveillance of antimicrobial resistance published in 2014 by the World Health Organization (WHO), the world is heading towards a post-antibiotic era, in which common infections and minor injuries may once again
Fecal microbial transplantation: a novel approach to eradicate antibiotic-resistant gut bacteria
The discovery of antibiotics in the early 20th century had an enormous impact on modern medicine, dramatically reducing mortality associated with infections. However, the emergence of drug – resistant pathogens has occurred due to greater availability and
Can solar driven processes effectively control antibiotic resistance and cytotoxicity during drinking water treatment?
Antibiotics, antibiotic resistant bacteria and antibiotic resistant genes have been detected in various aquatic environments because of the disposal of both treated and untreated wastewater. Their occurrence in water is a threat for human and animal health
Rapid and extremely reliable detection extended-spectrum ß-lactamases-producing Enterobacteriaceae
Resistance to antibiotics is becoming a worldwide issue mostly related to resistance observed in gram negative bacterial species such as in Enterobacteriaceae (Escherichia coli , Klebsiella pneumoniae) that are the most important source of hospital – and
Protecting titanium implants from infection
Certain microorganisms are capable of growing in layers, forming biofilms on medical surfaces, like implants, heart valves, etc… Biofilm-associated infections on implants are responsible for 15-25 % of implant failures as biofilms are resistant to most of the
Plasmid-mediated carbapenem and colistin resistance in E. coli – toward a dead end
The increasing trend in antibiotic resistance continues to threaten global health. Presently, multidrug resistance (MDR) in gram-negative rods is frequently observed not only with the occurrence of extended-spectrum ß – lactamase but also with producers of enzymes
Can bacteria resist a new antibacterial method?
Antibiotic resistance in bacteria is on the rise worldwide, making some previously-treatable infections incurable or even life-threatening. Thus there is a growing need for the discovery and development of new antibacterial methods of disinfection. Ideally these methods
Antibiotic sensing by a bacterial communication system
Bacteria compete using antibiotics. Bacteria compete with one another using an array of destructive compounds and strategies. For example antibiotics, used to treat infections, are produced by bacteria and other microbes and can kill competitors in mixed
Application of bacteria as microbial factories for natural products
Bacteria may be described as tiny chemical factories that take up simple molecules like sugars or alcohols as nutrients and utilize them to build all components that are necessary for basic cell metabolism, thus so called primary
Dendritic cells: Implication of molecular mechanism in allergic reaction to betalactam antibiotic
Adverse drug reactions are a serious health problem, accounting for 3% of revenue and becoming the fourth leading cause of death in the United States. These reactions include allergic reactions caused by specific immunological mechanisms, which are
Antibiotic resistance re-visited
With the introduction of antibiotics at the beginning of the 20th century, the threat of bacterial infections was thought to over. Today, antibiotics are still used as the first, if not only, line of defense against bacterial
