Tag Archives: atherosclerosis
Galectin-9: A new target for beating atherosclerosis?
Atherosclerosis is a chronic medical condition characterised by the accumulation of fat in the walls of blood vessels, which obstruct the normal flow of oxygen-rich blood and can have severe health consequences. Peripheral arterial disease (PAD) is
Macrophages in atherosclerosis; the good, the bad and the foamy?
Atherosclerosis is a chronic inflammatory condition in which arteries are narrowed due to the deposition of plaque material to the artery walls. This narrowing can give rise to other cardiovascular events like thrombosis or a stroke. One
Endothelial stiffening: a new parameter of endothelial damage in athero-susceptible regions of aorta
Atherosclerotic plaques that clog major arteries and lead to heart attacks and strokes are known to develop in sites exposed to non-unidirectional disturbed flow, such as bends and branches, whereas arterial segments that are straight and exposed
P2X7 antagonism: a specific tool to decrease inflammatory status in human atherosclerotic vessels?
Atherosclerosis is a dynamic progressive disease of the large arteries characterized by the tendency to accumulate lipids, inflammatory cells, smooth muscle cells and extracellular matrix within the sub-endothelial space, and progressing in unpredictable way to different stage.
L-arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation
Mediated by nitric oxide (NO), intact endothelial cells control vascular homoeostasis by regulating vascular tone and preventing smooth muscle cell proliferation, monocyte adhesion to the endothelium and platelet aggregation, thereby protecting blood vessels from the formation of
Zooming in on the ‘big eaters’ in atherosclerosis: a key role for oxidation and cellular localization of fat
Our sedentary lifestyle combined with the enrichment of fat in our diet has led to an increase of diseases affecting the health of our cardiovascular system. Cardiovascular disease is one of the leading causes of death, with
p38α MAP kinase inhibition in atherosclerosis – a new therapeutic tool?
Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide. Selective recruitment of monocytes into the arterial intima and their transformation into macrophage-derived foam cells is one of the earliest events in the pathogenesis of atherosclerosis. Foam
Small dense LDL, sub-clinical atherosclerosis and psoriatic arthritis
Psoriatic arthritis (PsA) is a chronic arthropathy associated with psoriasis, marked by an axial and/or peripheral joint involvement and high cardiovascular. Several large studies confirmed the relationship of small dense LDL (sd-LDL) with coronary events. Although some
Family, cholesterol and the genes from the ground up or why screening matters
In 1913, the “cholesterol theory” of atherogenesis was proposed. In the 1930s a genetic disorder, familial hypercholesterolemia (FH), which is associated with elevated levels of low-density lipoprotein (LDL) cholesterol and high risk of heart attack at an
Aorta tertiary lymphoid organs: Powerhouses of B cell immunity in atherosclerosis
Cardiovascular disease (CVD) is the leading cause of death worldwide. Yet, our understanding of how the immune system impacts CVD is very limited and immune system-based therapeutic approaches are not in sight. Lymphocytes are major cellular constituents
Licorice Root enhance cardiovascular health
The increasing incidence of lifestyle-based conditions–most notably those conditions that impact cardiovascular health, obesity, and blood sugar–has compelled consumers to consider natural solutions for these challenges. According to the Centers for Disease Control and Prevention (CDC), cardiovascular
A better way to measure heart disease risk for an overweight society
Low density lipoprotein (LDL) cholesterol or the “bad cholesterol” is an established measure of cardiovascular risk. LDL particles interact with the lining of the blood vessel and contribute to cholesterol loading in the arterial wall. Continued buildup
Collateral damages and self-inflicted scars by inflammation in cardiovascular diseases
Inflammation is a double-edged sword used by the body to initiate the healing process. However, persistence of immune responses can cause progressive destruction of tissues culminating in self-destructive autoimmune reactions which is a hallmark of many diseases.
The history of carotid stroke
Carotid artery disease is a condition in which fatty deposition (plaque) within the vessel wall of one or both neck arteries causes progressive vascular narrowing. Plaque surface rupture leads to a shower of debris to the brain,
Erasing atherosclerosis with nanoparticles and near-infrared laser
The advent of nanomedicine and near-infrared (NIR) optics allows the development and design of tools that enhance diagnosis and treatment of atherosclerosis. Clinical application of these technologies is anticipated in the near future. Our trial called NANOM-FIM
Development of anti-atherosclerotic drugs on the basis of cell models or how to make the elderly pay for placebos
The large research series has become internationally known in 1986 after a publication by the ex-Soviet minister of health as the first author and continues until today. In brief, cell cultures have been used for evaluation of
Researchers describe “imm-unifying theory” capable of explaining multiple medical problems
About a year ago, investigators at the Shock Trauma Center in Baltimore, MD found that patients who had organ transplants fared quite well after traumatic events. The authors of the manuscript, which was published in the Journal
