Tag Archives: Biomarker

Enlightening the importance of the NDRGs in the (cancerous) gut

Enlightening the importance of the NDRGs in the (cancerous) gut. AoS

The gastrointestinal (GI) tract is one of the most complex organs of the human body. With its approximate 5m length, a diversity of specialized epithelial cell types (the ‘lining’ of the GI tract), about 80% of our

Plasma CTSD activity: a non-invasive biomarker for hepatic insulin sensitivity

type 2 diabetes. AoS

Due to the obesity epidemic, the incidence and prevalence of type 2 diabetes mellitus continues to rise globally. Type 2 diabetes is characterised by a relative insulin deficiency and an impaired insulin sensitivity in certain specific target organs. Insulin sensitivity can

Analysis of serum biomarkers and their correlation with pain and quality of life in the rare disease alkaptonuria

Analysis of serum biomarkers and their correlation with pain

Alkaptonuria (AKU) is an ultra-rare disease causing an early onset, chronically debilitating spondylo-arthropathy due to deposition of an ochronotic pigment in joints and spine, which causes severe pain and greatly reduces patients’ quality of life. Despite an

How well can serum miRNAs diagnose amyotrophic lateral sclerosis patients?

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that damages motor neurons. As the disease progresses, patients gradually loose exercise capacity. Finally, they die due to the lack of breathability. No effective therapy was found for ALS

A new biomarker for Triple negative breast cancer MCP-1 drives cancer invasiveness and metastasis

Model of MCP-1 action in breast cancer cells

Breast Cancer is the second leading cause of mortality in women in the United States. Breast cancer arise in the ducts of the mammary glands that produces milk in a lactating breast. Breast cancers usually express various

Crossing borders to accelerate diagnosis of neurodegenerative diseases

Steps in biomarker development process

Neurodegenerative diseases of the Central Nervous System are affecting 50 million people worldwide. The forecast is that these numbers will steeply increase due to the aging population. These diseases are difficult to diagnose, due to a substantial

VMAT2: a novel biomarker for myopia

Myopia, with increasing prevalence and earlier age-of-onset, is the most common eye disease in the world. But its etiology is still unclear. Lots of studies have confirmed the hypothesis that dopamine (DA) is one of the important

Negative regulators of cell death signalling pathways in cancer

Cancer is a primary cause of human death with a global economic toll of around US$1.4 trillion each year. It is estimated that about 12 million people will yearly die of cancer by 2030. Conventional cancer therapies such

Potential biomarkers of CDK4/6 inhibitors in HR-positive advanced breast cancer

Thanks to the development of endocrine therapy, the mortality rate of estrogen receptor (ER)-positive breast cancer patients has been decreased drastically. In spite of the improvement, however, relapse and progression that are driven by different mechanisms are

A novel biomarker for oral cancer

Tongue squamous cell carcinoma (TSCC) is the most predominant form of oral cancer in developed countries with varying incidence in developing countries wherein diverse etiological factors such as chewing betel-quid comprising betel leaf, areca nut and slaked

9th World Biomarkers Congress. Madrid, Spain. December 07-08, 2017

World Biomarkers 2017 is organized around the theme: “A New Era of Diagnosis and Clinical Research”. World biomarkers, in the hands of clinical investigators, provide a dynamic and powerful approach to understanding the spectrum of diseases with

Conformal invariants for landmark curve based brain morphometry analysis

Abnormal structural changes measured on cortical surfaces are important biomarkers for Alzheimer’s disease (AD). In brain imaging research, landmark curves are usually delineated on cortical surfaces to represent significant sulcus and gyrus patterns. Landmark curves are widely

How did computers help us to find biomarkers for corticosteroid resistance in asthma through systems biology approach?

Asthma is a chronic disease that affects the lower airways, hampering the air movement in the lungs and the gas exchange. Asthma is characterized by bronchial inflammation that, particularly during an asthma attack, results in difficulty of

The protein p62 helps liver cancer-initiating cells survive

The most common form of adult liver cancer is hepatocellular carcinoma (HCC), which is the third-leading cause of cancer deaths worldwide. HCC arises from persistent liver inflammation related to hepatitis B or C infection, alcohol consumption, or

Biomarker Europe Summit 2016

Organizer: GTCbio Start date: October 5th, 2016 End date: October 7th, 2016 GTCbio would like to invite you to attend our Biomarker Summit Europe 2016 on October 5-7, 2016  in Berlin, Germany! The summit will address the

Serum osteopontin as a novel biomarker for muscle regeneration in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is an X-linked muscular disease, affecting boys in principle. It is caused by mutations in the gene coding for dystrophin, a membrane-related structural protein in skeletal and cardiac muscles. The lack of dystrophin

Special molecular mechanism makes CD147 an interesting drug target in cancer or autoimmune diseases

T cells are important players of the immune system, recognizing foreign or dangerous agents with their unique receptors. They defend the body from these agents either directly by killing or by recruiting or regulating other immune system

Neurophysiological biomarkers as a method to evaluate effects of drugs

When it comes to treatment of brain diseases not affecting the motor-system, drug development has proven difficult, because the majority of tests of drug-effects in animal experiments rely on changes in the behavior of the treated subject.

Ultrasensitive detection and glycan analysis of a prostate cancer biomarker

In recent years we have seen an increased frequency of diagnosed prostate cancer (PCa) cases accompanied with an enhanced mortality worldwide. Symptoms of an early-stage PCa can be mild or even absent, thus there is an urgent

Osteopontin is a novel player and potential biomarker in hepatosplenic schistosomiasis mansoni

Schistosomiasis or bilharzia is a tropical disease caused by worms of the genus Schistosoma. Over 440 million people from 76 countries and territories are infected (Fig. 1). This water-based disease is considered the second most important parasitic