Tag Archives: Biomarker
Emerald Ash Borer attacks trees revealing early chemical clues
The Emerald Ash Borer (EAB), Agrilus planipennis, is a major global forest pest (a buprestid beetle) that has decimated ash trees (Fraxinus species) throughout Europe and Asia. Since this nonnative invasive insect was introduced into the U.S.
The use of olfactory neuronal precursors for antemortem Alzheimer’s Disease diagnosis
Alzheimer’s disease (AD) is a disabling and progressive illness that causes a high social cost and economic burden. Current diagnosis has been done by clinical appreciation based on the Diagnostic and Statistical Manual of Mental Disorders (DSM–5) and
DARC – A light at the end of the tunnel
Glaucoma is the leading cause of irreversible blindness, affecting more than 70 million people worldwide. Visual loss is attributed to death of nerve cells, called retinal ganglion cells (RGCs), in the back of the eye. There is
Specific and non-specific biomarkers in neuroendocrine gastroenteropancreatic tumors
Neuroendocrine tumors (NETs) are a heterogeneous group of rare malignancies that can arise in almost all organs, although gastroenteropancreatic site (GEP) is the most common. Symptoms are rarely specific, and clinical manifestations may be evident only in
Bayesian sparse neural networks for biomarker discovery with omics data
Recent advances in high-throughput biotechnologies, such as microarray and sequencing technologies, have provided an unprecedented opportunity for biomarker discovery, which potentially enhances the development of precision medicine. From a statistical point of view, the discovery of biomarkers
miRNA, the inconspicuous but key player in the development of cervical cancer
Cervical cancer is among the top three cancers affecting women below 45 years in several countries. Both the alterations and modification in deoxyribonucleic acid (DNA) sequences play a critical role in the onset and progression of cervical
Enlightening the importance of the NDRGs in the (cancerous) gut
The gastrointestinal (GI) tract is one of the most complex organs of the human body. With its approximate 5m length, a diversity of specialized epithelial cell types (the ‘lining’ of the GI tract), about 80% of our
Plasma CTSD activity: a non-invasive biomarker for hepatic insulin sensitivity
Due to the obesity epidemic, the incidence and prevalence of type 2 diabetes mellitus continues to rise globally. Type 2 diabetes is characterised by a relative insulin deficiency and an impaired insulin sensitivity in certain specific target organs. Insulin sensitivity can
Analysis of serum biomarkers and their correlation with pain and quality of life in the rare disease alkaptonuria
Alkaptonuria (AKU) is an ultra-rare disease causing an early onset, chronically debilitating spondylo-arthropathy due to deposition of an ochronotic pigment in joints and spine, which causes severe pain and greatly reduces patients’ quality of life. Despite an
How well can serum miRNAs diagnose amyotrophic lateral sclerosis patients?
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that damages motor neurons. As the disease progresses, patients gradually loose exercise capacity. Finally, they die due to the lack of breathability. No effective therapy was found for ALS
A new biomarker for Triple negative breast cancer MCP-1 drives cancer invasiveness and metastasis
Breast Cancer is the second leading cause of mortality in women in the United States. Breast cancer arise in the ducts of the mammary glands that produces milk in a lactating breast. Breast cancers usually express various
Crossing borders to accelerate diagnosis of neurodegenerative diseases
Neurodegenerative diseases of the Central Nervous System are affecting 50 million people worldwide. The forecast is that these numbers will steeply increase due to the aging population. These diseases are difficult to diagnose, due to a substantial
VMAT2: a novel biomarker for myopia
Myopia, with increasing prevalence and earlier age-of-onset, is the most common eye disease in the world. But its etiology is still unclear. Lots of studies have confirmed the hypothesis that dopamine (DA) is one of the important
Negative regulators of cell death signalling pathways in cancer
Cancer is a primary cause of human death with a global economic toll of around US$1.4 trillion each year. It is estimated that about 12 million people will yearly die of cancer by 2030. Conventional cancer therapies such
Potential biomarkers of CDK4/6 inhibitors in HR-positive advanced breast cancer
Thanks to the development of endocrine therapy, the mortality rate of estrogen receptor (ER)-positive breast cancer patients has been decreased drastically. In spite of the improvement, however, relapse and progression that are driven by different mechanisms are
A novel biomarker for oral cancer
Tongue squamous cell carcinoma (TSCC) is the most predominant form of oral cancer in developed countries with varying incidence in developing countries wherein diverse etiological factors such as chewing betel-quid comprising betel leaf, areca nut and slaked
9th World Biomarkers Congress. Madrid, Spain. December 07-08, 2017
World Biomarkers 2017 is organized around the theme: “A New Era of Diagnosis and Clinical Research”. World biomarkers, in the hands of clinical investigators, provide a dynamic and powerful approach to understanding the spectrum of diseases with
Conformal invariants for landmark curve based brain morphometry analysis
Abnormal structural changes measured on cortical surfaces are important biomarkers for Alzheimer’s disease (AD). In brain imaging research, landmark curves are usually delineated on cortical surfaces to represent significant sulcus and gyrus patterns. Landmark curves are widely
How did computers help us to find biomarkers for corticosteroid resistance in asthma through systems biology approach?
Asthma is a chronic disease that affects the lower airways, hampering the air movement in the lungs and the gas exchange. Asthma is characterized by bronchial inflammation that, particularly during an asthma attack, results in difficulty of
The protein p62 helps liver cancer-initiating cells survive
The most common form of adult liver cancer is hepatocellular carcinoma (HCC), which is the third-leading cause of cancer deaths worldwide. HCC arises from persistent liver inflammation related to hepatitis B or C infection, alcohol consumption, or
