Tag Archives: blood

Profiling biologics in circulating human whole blood

Functional and safety assessments of biologics prior to first-in-human (FIH) is key to understand the mode-of-action and safety profile. We have made use of an ex-vivo whole blood assay for its potential in assessment of antibody-based drug

Uremia. A history of urine in the blood

The term uremia was first introduced in 1847; literally translated, it means “urine in the blood.” Today, uremia describes the myriad of symptoms and organ derangements that result from the failure of the kidneys in its normal

Endothelial stiffening: a new parameter of endothelial damage in athero-susceptible regions of aorta

Atherosclerotic plaques that clog major arteries and lead to heart attacks and strokes are known to develop in sites exposed to non-unidirectional disturbed flow, such as bends and branches, whereas arterial segments that are straight and exposed

Fasting blood glucose and prostate cancer: A meta-analysis of dose-response

Prostate cancer (PCa) is the most common cancer, and third leading cause of cancer deaths, in American men. So far, only a few well-established risk factors, including ageing and being racially black, are thought to be associated

Increased blood immune regulation in autoimmunity?

Through centuries, the immune system evolved to become highly proficient in protecting the human body from invading threats. Part of its strength relies on antibodies produced within germinal centres (GC). These structures form intricate networks of immune

Early pregnancy regulates Toll-like receptors expression in ovine trophoblasts and peripheral blood leucocytes

Interferon-tau (IFN-t), released from the embryonic trophoblasts, is the first embryonic signal in ruminants and drives the process of maternal recognition of pregnancy. It possesses critical functions such as regulation of prostaglandin secretion, conceptus elongation, immunological tolerance,

Acute immune responses in the brain differ from responses in blood

Immune cells of the brain called microglia, appear to have been adapted to their vulnerable environment. They react less destructive to danger signals than their counterparts in the blood. Microglia are the resident macrophages of the central

The enigma of blood pressure variation

The circulation of blood throughout the body comes from the continuous rhythmic pumping action of the heart. Specifically, a pulsatile flow of blood happens when the blood within the heart is ejected out the left ventricle into

Donor in recipient – dangers in DNA profiling after allotransplantation

The incidence of cancers, which rank among some of the most common lifestyle diseases of the 21st century, is rising steadily year by year. The trend is attributable to the ageing of societies, increase in life expectancy

Pancolonic varices and portal venous overload

Colonic arterio-venous malformation, although a rare disease, merits to be known as possible cause of severe lower digestive haemorrhage, which often constitutes the first clinical symptom. Colonoscopy usually represents the first diagnostic tool, demonstrating grossly enlarged vessels

Cancer can growth without angiogenesis. A new field opened in cancer biology

The word cancer derives from the Greek “karkinos “which means “crab”.  According to the legend reported by Paul of Aegina in the 7th Century AD, this name was chosen because this disease “has the veins stretched on

A surgical treatment for high blood pressure

According to the Center for Disease Control and Prevention, 70 million Americans are diagnosed with high blood pressure, also referred to as hypertension in the medical field. The majority of these individuals are not experiencing any symptoms

Jurassic siphon

The sauropod dinosaurs were the tallest animals to ever stalk the earth. The fossilised remains of sauropods indicate that some had necks as long as 12 m.  Sauropods are often depicted with their heads held high –

Nocardia donostiensis

Edmond Nocard was a French veterinarian and microbiologist born in Provins in 1850. One of his main contributions to medicine was the discovery of a bacterial genus called “Nocardia” on his honor. Most of the species belonging

Genetic disorders in primary aldosteronism – familial and somatic: an explanatory attempt

Aldosterone is the steroid hormone secreted from the adrenal gland in response to sodium deficiency, blood volume loss or potassium loading. It acts on the kidney and the colon to retain sodium and excrete potassium, in a

Superhydrophobic plasma separator for point-of-care diagnostics

Blood is a complex, heterogeneous fluid containing red blood cells, white blood cells, platelets and plasma. Blood is a mirror of health and disease since it contains numerous diagnostic biomarkers that are indicators of infectious diseases, cancer,

From crime scene to crime lab: potential interactions between blood detection methods

Crime scene investigators and forensic scientists at the crime laboratories both utilize rapid, presumptive tests to determine the likelihood of the presence of blood.   At the crime scene, investigators commonly utilize Bluestar® or Luminol to produce a

The earlier, the better and the controlled. Glucose level sensing in diabetic patients through nano biosensors

Gone are the days when there was a big pain for patients suffering from high blood glucose (blood sugar) level that early and rapid detection was a long wait & rather unpleasant. Now recently developed approaches using

Bloody stool due to ulcerative colitis during low-carbohydrate weight-loss diet

The prevalence of overweight and obesity is a global concern. Therefore, various weight-loss diets have been developed. A low-carbohydrate weight-loss diet, also known as the Atkins diet, is one such diet. In the United States, the proportion

A better, safer clot buster for heart attacks, strokes and other cardiovascular diseases

A clot that obstructs blood flow triggers the onset of most heart attacks and 85% of strokes, the leading causes of death and disability worldwide.  Reestablishing blood flow rapidly limits damage to the heart or brain, saves