Tag Archives: bone marrow
Treatment critical limb ischemia with intramuscular administration of mesenchymal stem cells
Critical limb ischemia (CLI) is a severe form of peripheral artery disease, and associated with high rate of morbidity and mortality. The current standard for treatment CLI is revascularization. However, in any time surgical or endovascular revascularization
Bone marrow chilling could warm the body
In order to keep warm during cold exposure, heat production must be increased. This can be achieved through non-shivering and shivering thermogenesis. The main tissue involved in non-shivering thermogenesis is brown adipose tissue (BAT) which is located
FTIR spectroscopy and ımaging to understand donor age effect on bone marrow mesenchymal stem cells
Stem cells, like Bone Marrow Mesenchymal Stem Cells (MSCs), have enormous potential to develop new therapies for tissue regeneration and repair with their ability to differentiate into many different types of cells. The aging process and the
Under pressure: a stem cell’s journey home
Hyperbaric oxygen therapy (HBOT) involves breathing in pure oxygen at an air pressure three times higher than atmospheric pressure. This allows more oxygen to enter the lungs, dissolve into the circulation, and ultimately reach cells. The future
Making mountains out of molehills: how stem cells become platelets
You have 100,000 km of plumbing (blood vessels) in your body. What then keeps them from leaking? This essential work is carried out by tiny cells called platelets, which are able to form a plug to stop
The importance of immature cancer cells in predicting patient outcome
The word “cure” for breast or any other type of cancer might be unfair to a patient since this will give the individual a false sense of comfort. The misuse of `cure’ is evident in breast cancer
The use of bone marrow-derived mononuclear cells ameliorates airway inflammation in horses with recurrent airway obstruction
Horses stabled indoors live in a pro-allergenic environment and are exposed to molds, mites, and bacterial endotoxins from hay and bedding. This exposure exacerbates recurrent airway obstruction (RAO), an asthma-like disease. Affected horses suffer from recurrence of
Crafting and grafting of new cells to treat epidermolysis bullosa
Epidermolysis bullosa (EB) is a disease that causes the skin to become extremely fragile, which leads to the formation of blisters. Depending on the form the disease takes, ranging from relatively mild to terribly severe, the blistering
Outcomes of Influenza infections in hematopoietic cell transplant recipients
Influenza infection causes mild disease in most cases and severe complications in very few cases. The severity of influenza infection depends mainly on the type of influenza virus and the status of the patient’s immune system. Since
“Good kids in bad neighborhoods” – the role of bone marrow microenvironment in the development of acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common and aggressive blood cancer in adults and is associated with a high rate of mortality due to cancer therapy resistance and disease relapse. AML is characterized by severe deficiency
ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling
Cardiovascular diseases are disorders of the heart and blood vessels which are leading to heart failure. Cardiovascular diseases correspond to 30% of all deaths in the world. The molecular processes that undergone from a healthy heart to
Bone marrow transplantation resets the clock in patients with Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) accounts for about one third of all of leukemias. In the United States 15,000 patients are diagnosed with and 4,500 patients die of CLL every year. CLL is a diverse disease. Some patients
Red blood cell survival in very low birth weight neonates
In normal, healthy adults red blood cells (RBCs) are produced in the bone marrow and survive in the circulation for about 4 months. After this time they cease functioning normally and are removed by as yet poorly
