Tag Archives: bone

Unlocking new treatments for bone diseases: using PEPITEM to strengthen bones and prevent loss

Despite appearances, bones are a constantly changing organ in the body. Cells that produce new bone (named osteoblasts) and cells that break down bone (named osteoclasts) work in harmony to ensure that old bone is continuously replaced,

Autophagy suppression decreases craniofacial bone mass

AoS. Autophagy suppression decreases craniofacial bone mass

Macroautophagy (hereafter autophagy) is the main intracellular degradation mechanism to maintain cellular homeostasis by degrading misfolded proteins, recycling dysfunctional organelles, and generating energy fuels under physiological and pathological conditions. Autophagy consists of two major steps: autophagosome formation,

The dental nerve circulates in a canal within the mandible

The dental nerve circulates in a canal within the mandible. AoS

The inferior alveolar nerve (IAN) is a sensitive branch of the trigeminal nerve, the 5th pair of cranial nerves. It has an intraosseous path in the mandible, inside the mandibular canal, where it is accompanied by lymphatic,

Bone marrow chilling could warm the body

Bone marrow chilling could warm the body

In order to keep warm during cold exposure, heat production must be increased. This can be achieved through non-shivering and shivering thermogenesis. The main tissue involved in non-shivering thermogenesis is brown adipose tissue (BAT) which is located

Large animal models for osteoporosis research: The small ruminants (sheep and goat)

Role of oestrogen in bone remodeling

In the healthy skeleton, constant bone remodeling occurs in which mature bone tissue is removed, in a process called resorption, and new tissue is formed in order to maintain bone strength and mineral homeostasis in continuum with

How salt hate your bones: the nexus between high dietary salt intake and bone loss

High dietary salt intake induces bone loss by enhancing bone lethal Th17 cells and suppressing bone protecting Treg cells.

Osteoporosis weaken bones making them fragile and highly susceptible to fractures due to reduction in bone mass via depletion of bone minerals. This leads to higher incidences of fractures many folds responsible for enhanced morbidity and mortality.

Bone microstructure and the size of your femur

Bone microstructure and the size of your femur

Human bones are often thought to be static tissues because of their hard structure. However, in addition to mineral they also contain collagen. This combination gives your bones flexibility in adapting to exercise. Adult bones can respond

Optimization of fracture healing by improved stabilization

Millions of fractures occur every year worldwide. Most of them heal uneventfully but 5-10 % show delayed healing or non-union. This leads to a great burden for the patients and high economic load for the healthcare system.

Noni leaf, black tea and Black cohosh encouraged bone growth in post-menopausal mammals

High intake of black tea and certain types of flavonoids were associated with lower risk of fracture-related hospitalizations in elderly women at high risk of fracture. Black tea consumption increased serum estradiol and prevented bone loss in

New therapy for the treatment of childhood bone cancer

Cancer in children and young adults is rare, with survival rates being very high, mainly depending on the treatment. The biggest proportion of this diagnosis will be on leukaemia and brain tumours, with just about 3% of

Osthole: a natural approach to speed up bone fracture healing

Bone fractures are among the most common orthopedic problems happen to many of us. Although our body will naturally repair broken bone, the healing process takes weeks, months, or even years depending on severity of injury and

Osteosarcoma – lost in translation

A 16-year-old boy with pain around the knee of two months’ duration demonstrates a lesion in the epiphysis of the distal femur (long bone). The differential diagnosis may be broad, but the pathologist is able to achieve

A new perspective on guided bone regeneration in foot surgery with heterologous materials

Guided bone regeneration (GBR), developed in 1976 by Melcher, is a surgical procedure used to increase the amount of bone volume. It uses barrier membranes with or without particulate bone grafts or/and bone substitutes. The basic principle

Bone from tissue banking to regenerate the lost bone jaws induce the production of antibodies

Dental implants have shown important role in dentistry, reaching success rates in osseointegration at the order of 97% of cases. The dental implant is a titanium device which is positioned in the alveolar bone, so as to

Can Radon radiation become a source of treatment for Rheumatoid Arthritis?

Rheumatoid arthritis (RA) is the most common type of autoimmune disease. It is triggered by a faulty immune system of the body. However, the real cause of the disease is not completely known. The disease affects the

A New therapy for healing nonunion fractures in patients using self-bone marrow derived mesenchymal

Sometimes a broken bone fail to heal (“nonunion”) and it is necessary to induce the formation of new bone tissue to connect the broken pieces. Investigators from the Instituto Venezolano de Investigaciones Cientificas (IVIC) and orthopedic surgeons

Effect of Femoral offset in THA ?

The Femoral Offset (FO) is defined as the perpendicular distance between the femoral head’s center of rotation and the long axis of the femur, which is estimated using an anteroposterior (AP) radiograph of the pelvis as shown

Materials for tomorrow: right next to us!

The idea of an artificial device able to help human parts to regenerate or to replace entirely one of the body functions attracted the attention of research teams around the world. During recent years, a route of

Theophylline, a drug to treat asthma increases risk of fracture and causes vitamin D deficiency

Incidence of chronic obstructive pulmonary diseases (COPD) of which asthma is the commonest manifestation is growing by leaps and bounds in two most populous countries, India and China due to rapid growth of industrialization and associated rise

Massive septic pelvic osteolysis following revision total hip arthroplasty in a patient with sickle cell anemia

Sickle cell anemia (SCA) is a hematologic disorder characterized by production of abnormal hemoglobin and often (50%) complicated with bone infraction, hip osteonecrosis etc. Surgical treatment of these complications is often postponed because of a variety of