Tag Archives: breast cancer
Rabbits with mammary carcinomas as a model for comparative pathology and translational science in breast cancer research
Within a breeding colony of rabbits, the American pathologist Harry Greene (1904-1969) observed that mammary carcinomas were restricted to certain families. This is suggestive of a familiar predisposition as it occurs in human breast cancer. In rabbits,
Does tangential radiation for breast cancer cover internal mammary nodes?
Breast cancer is one of the most common cancers in women in the United States. Radiation is a very commonly used treatment modality for breast cancer: it is offered to nearly all patients after lumpectomy (removal of
Altered methylation in Breast Cancer in very young women
Breast cancer has the highest incidence rate of all cancers in women worldwide. Although early breast cancer generally has an excellent prognosis, breast cancer in young women (under the age of 35) is associated with a high
An integrated genomics approach for identifying breast cancer patients with highly aggressive tumors
Breast cancer is the most common cancer in women with over 2 million new cases worldwide in 2018. Three kinds of receptors are usually found on the surface of breast cancer cells: a receptor for female hormone
Compressed ultrasound imaging: finding tumors with a few transducers
Currently, ultrasound imaging is predominantly done by a probe that possesses many transducers, which are small devices that transmit, and then receive, acoustic waves. Decreasing the number of transducers, while maintaining image quality, is surely a desirable
2nd International Women Health and Breast Cancer Conference. London, UK. August 13-14, 2020
Following the success of i-Women Health 2019, we welcome you to the 2nd International Women Health and Breast Cancer Conference in London during August 13-14, 2020. i-Women Health 2020 provides an international forum for academicians, practitioners, health
Keeping a clean house to suppress HER2+ breast tumor growth
Autophagy (self-eating) is a process used by normal cells to keep a “clean house”. It degrades abnormal or damaged proteins and organelles, helps to fight infections and also provides energy during periods of fasting or exercise. Besides
A new biomarker for Triple negative breast cancer MCP-1 drives cancer invasiveness and metastasis
Breast Cancer is the second leading cause of mortality in women in the United States. Breast cancer arise in the ducts of the mammary glands that produces milk in a lactating breast. Breast cancers usually express various
Adopting mammary development gameplay in breast cancer initiation and progression
The process by which the breast changes during puberty and lactation is incredibly unique. Those changes are essential for the functional mammary gland. These changes are triggered and orchestrated by hormones. Such hormonal changes start during pregnancy
The importance of immature cancer cells in predicting patient outcome
The word “cure” for breast or any other type of cancer might be unfair to a patient since this will give the individual a false sense of comfort. The misuse of `cure’ is evident in breast cancer
Tissue-specific MED1 LxxLL motifs play critical roles in HER2-driven breast cancers
Estrogen Receptor (ER) is a nuclear hormone receptor that plays important roles in normal mammary gland development as well as breast cancer growth and metastases. In a breast cancer setting, when ER is bound by estradiol, there is
Potential biomarkers of CDK4/6 inhibitors in HR-positive advanced breast cancer
Thanks to the development of endocrine therapy, the mortality rate of estrogen receptor (ER)-positive breast cancer patients has been decreased drastically. In spite of the improvement, however, relapse and progression that are driven by different mechanisms are
Lower TSH and higher free thyroxine predict incidence of prostate but not other common cancers
The pituitary gland signals production of thyroid hormones by the thyroid gland through secretion of thyrotropin (TSH). There are two types of thyroid hormones produced by the thyroid gland. These include thyroxine (T4) and tri-iodothyroinine (T3). These
Obesity fuels breast carcinogenesis: What is the molecular basis?
Excess body weight is associated with the primary risk of 13 distinct cancers and is generally considered a poor prognostic indicator for patients diagnosed with a variety of malignancies. Obesity is increasingly recognized as a risk factor
What is a SERM and how does it work?
Estrogen receptors (ERα and ERβ) are nuclear receptors that function as ligand-dependent transcription factors. They play a vital role in many physiological functions such as the development and differentiation of the reproductive tract and mammary gland. They
Transmitted sound wave mammography
This study was designed to look at a new type of totally harmless breast imaging called whole-breast transmission ultrasound to see if it could do something mammography cannot do – that is to diagnose the presence of
New treatments for breast cancer
Now that 90% of women diagnosed with breast cancer will live at least 5 years, new treatments are aim at improving outcomes for the 10% who are not responding to current drugs and delivering treatments with less
A new extracellular role for miR-939 in triple negative breast cancer
Triple negative breast cancer (TNBC) is defined as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) negative breast carcinomas (BC). Unfortunately, this kind of tumor is characterized by poor prognosis, high
Next generation sequencing, a new gold standard for clinical gene panel testing
The adaption of the Next Generation Sequencing ( NGS ) technology to clinical laboratories has revolutionized the molecular diagnostics by reducing the costs and increasing the throughput. Clinical use of NGS enables simultaneous testing of multiple genes
Let-7b expression in breast cancer: does have any implications on the DNA repair capacity?
Epigenetics study the changes on gene expression that occur without altering the primary structure of the DNA. Examples of epigenetic mechanisms that can produce such changes include microRNA ( miRNA ) silencing, DNA methylation, histone methylation, among
