Tag Archives: breast cancer
Teasing apart the roles that oncogenic miRNAs play in breast cancer
Oncogenic miRNA and breast cancer Since the early 2000’s, the field of RNA has been contributing to major discoveries in cancer research. McroRNAs are small RNA molecules (miRNA), inhibit the messenger RNAs that produce our proteins. Normally,
Radiation-induced morphea: an under-recognized complication of breast radiation
Worldwide, breast cancer was the most common new diagnosis and common cause of death in women in 2012. As screening for breast cancer has improved patients are often identified in the early stage of disease and are
An RNA degradative enzyme that stimulates breast cancer cells to move and invade
RNA degradative enzymes carry out key steps in regulating gene expression. They are broadly grouped into two groups; exonucleases, that degrade RNA from one end and endonucleases, which cut within the body of an RNA molecule. PMR1
Metabolic reprogramming: from estrogen dependence to self-sufficiency
Breast cancer is the most common cancer in women and, despite significant progress in diagnosis and treatments, incidence has been steadily increasing in the last 40 years. Approximately 70% of breast cancers are characterised by the expression
Discovery of potential anti-breast cancer agents dual targeting ER and VEGFR-2
Breast cancer (BC) is the most common cancer in females worldwide. Among all BC patients, more than 70% are diagnosed as estrogen receptor positive (ER+). Estrogen is the primary female hormone which is responsible for the development
Focusing on the most relevant gene variants in inherited breast and ovarian cancer
Modern sequencing technology (which has begun to become adopted in clinical labs) can provide invaluable genetic information of individuals, such as those with a family history of early onset breast cancer. However, this information also results in
Why women with early stage breast cancer don’t complete their chemotherapy treatment?
Breast cancer is a leading cause of cancer death among US women. For women with early stage breast cancer (stages I and II), completing chemotherapy after surgery can increase survival. Despite this proven benefit, some women do
FDG-PET/CT is accurate in diagnosing breast cancer recurrence
A woman with a substantial risk of breast cancer recurrence experiences worry and anxiety, and a correct diagnosis is relevant in order to make well-founded decision on treatment strategy. It is then crucial to provide accurate diagnostic
The synergistic role of prolactin and estrogen in breast cancer requires PAK1
In 2016, the American Cancer Society estimates about 40,000 deaths will result from breast cancer. This makes breast cancer the second leading cause of cancer-related among women. Despite the frightening statistics, the death rates from breast cancer
Androgen receptor; a tale of two cancers
Prostate cancer and breast cancer share similarities as hormone related cancers with a wide range of heterogeneous settings. Macklin, as early as 1954, provided evidence for a significantly higher frequency of prostate cancer among relatives of breast
Polyfunctional T cells induced potent anti-tumor efficacy
Adoptive T cell therapy is a form of cancer immunotherapy using T cells to target cancer cells. In adoptive T cell therapy, white blood cells are collected from cancer patients, T cells (CD4+ and CD8+ cells) within
A promising novel drug for breast cancer
The reason cancer is so difficult to treat is that cancer cells are our own cells running wild, which means that they generally do not make any protein or other molecule that normal cells don’t make. This
Screening breast MRI in patients with personal history of breast cancer
This study looked at patients who had a personal history of breast cancer diagnosed at a premenopausal age to see if having screening breast MRI provided a benefit to the patient. Patients with a personal history of
Type of breast cancer provides clues to genetic susceptibility
Breast cancer is a common disease affecting 1 in 11 women in the UK but like many common cancers incidence increases with increasing age. Only 1 in 1,700 women younger than 30 and 1 in 228 women
Omega-3 fatty acids, obesity and breast density
Omega-3 fatty acids, abundantly present in fish oil products, are in large use among the public because of the widespread perception that they are able to ameliorate and even prevent many chronic diseases, including cancer. Our research
Importance of updating prognostic predictions: an example from breast cancer
Today prognostic prediction models are an integral part of clinical practice in many fields. They are typically used to access the risk of an event in the future after a well-defined starting point, for instance the risk
A new target in the fight against breast cancer
Cancer cells differ from normal cells in many ways, including their abnormal growth and their ability to change shape and migrate to other tissues. These differences are partly caused by changes in the production of proteins and
Breast cancer in elderly – does guideline adherent treatment really matter?
It is well known that breast cancer is currently the most common female cancer. Advances in diagnostics and treatment continuosly improve the long term outcome. To establish a new agent or therapy a randomised study with inclusion
“Chemobrain” prior to cancer treatment? The cause is probably cancer-related post-traumatic stress
Cancer patients often complain about deficits of attention, memory, and other basic cognitive functions, which considerably impact on their lives. Long time, these problems were simply attributed to side effects of chemotherapy and have therefore been termed
A functional immune system against cancer in breast cancer patients
One of the hallmarks of cancer development is the ability of tumor cells to evade the recognition by the host immune system. However, the presence of immune responses against cancer is frequently observed in cancer patients. The
