Tag Archives: cancer

Harbinger of increased prostate cancer risk: The effect of decreased prostate cancer screening

Harbinger of Increased Prostate Cancer Risk. Atlas of Science

Since the introduction of prostate-specific antigen (PSA) as a blood test in 1992, the number of men diagnosed with prostate cancer increased dramatically. Because PSA detects men who are asymptomatic two things occurred. First, many of the

The RAS mRNA G-quadruplex: making undruggable cancer targets druggable

The RAS mRNA G-quadruplex. AoS

In many cancers, RAS proteins are constitutively activated by their oncogenic mutations or activation of their upstream molecules. RAS proteins play a central role in cancer cell malignancy, and drugs that target RAS are therefore believed to

Compressed ultrasound imaging: finding tumors with a few transducers

Compressed Ultrasound Imaging with Holey Cavities. AoS

Currently, ultrasound imaging is predominantly done by a probe that possesses many transducers, which are small devices that transmit, and then receive, acoustic waves. Decreasing the number of transducers, while maintaining image quality, is surely a desirable

2nd International Women Health and Breast Cancer Conference. London, UK. August 13-14, 2020

2nd International Women Health and Breast Cancer Conference

Following the success of i-Women Health 2019, we welcome you to the 2nd International Women Health and Breast Cancer Conference in London during August 13-14, 2020. i-Women Health 2020 provides an international forum for academicians, practitioners, health

How to stain E-selectin ligands in tumor tissue

How to stain E-selectin ligands in tumor tissue

Cancer affects millions of people around the world. Nowadays they have more chances to survive, but still, the most frightful scenario are metastases. Few patients with metastases survive, and there is an unmet clinical need for new

Chemical toxicity study of some Algerian medicinal plants

About 65 to 80% of the world’s population use traditional medicine for their primary health WHO according to the WHO report. However, the use of herbal medicines has come under scrutiny due to their perceived long-term toxicity

The voltage-gated potassium channel, Kv1.3, at the crossroads of glial functions in glioma

The voltage-gated potassium channel, Kv1.3, at the crossroads of glial functions in glioma

Glioblastoma multiforme (GBM) is one of the most lethal cancers in adult humans, with a frequency of 6:100.000 people. Despite the current three-modality therapy, which includes surgery, radiation and chemotherapy, the clinical outcome of GBM patients remains

How cancer cells communicate with nervous and immune systems

In the last decade, studies have shown that cancer cells can influence their environment and bi-directionally communicate with other systems including immune and nervous systems. The neuro-immune interaction is a key player in influencing cancer development and

Can the heart get cancer? Quite rare, but yes

Can the heart get cancer

To many, the heart seems as an unusual location for cancer. In fact, most tumors that affect the heart are metastatic in origin (start in other organs and disseminate to the heart). Primary cardiac tumors (tumors that

LMO1 regulates a novel oncogenic pathway druggable for neuroblastoma

LMO1 regulates a novel oncogenic pathway druggable for neuroblastoma

Neuroblastoma (NB) is derived from neural crest cells and its main developing sites are adrenal gland and sympathetic ganglions. It is the most common extracranial solid tumor in childhood, accounting for more than 7% of malignancies in

Keeping a clean house to suppress HER2+ breast tumor growth

Keeping a clean house to suppress HER2+ breast tumor growth

Autophagy (self-eating) is a process used by normal cells to keep a “clean house”. It degrades abnormal or damaged proteins and organelles, helps to fight infections and also provides energy during periods of fasting or exercise. Besides

A new biomarker for Triple negative breast cancer MCP-1 drives cancer invasiveness and metastasis

Model of MCP-1 action in breast cancer cells

Breast Cancer is the second leading cause of mortality in women in the United States. Breast cancer arise in the ducts of the mammary glands that produces milk in a lactating breast. Breast cancers usually express various

miR-146 and miR-155, two key modulators of the immune response and of the oncogenic transformation

miR-146 and miR-155, two key modulators of the immune response and of the oncogenic transformation

Micro-RNA (miRNAs or miRs) are small noncoding RNAs that negatively regulate protein coding gene transcripts and exert an important role in the control of gene expression. miRs are deregulated in many tumors and play an active role

Targeting cholesterol metabolism to suppress prostate cancer metastasis

Targeting cholesterol metabolism to suppress prostate cancer metastasis

Metastatic prostate cancer is the second leading cause of cancer death in men worldwide. Prostate cancer itself is one of the most common cancers in men. At the early stages, localized prostate cancer usually grows slowly and

Chronic pancreatitis: an inflammatory disease of pancreas

Chronic Pancreatitis: An Inflammatory Disease of Pancreas

Pancreas is very important organ in our body and it is located in the abdomen behind the stomach. Pancreas is a gland and secrets some chemicals called enzymes. It is a leaf like structure and divided in

Enrichment, quantification and glycan analysis of prostate cancer oncomarker in a single step

In recent decades, there is an increasing trend in prostate cancer occurrence and mortality worldwide, caused partly by a more available diagnostics, prolonged life period but also increased risk factors present in the environment. Most commonly, age

Targeting microRNAs for thyroid cancer therapy

Schematic model explaining the oncogenic actions of miR-146b and the consequences of its inhibition in thyroid cancer

The thyroid gland is a small butterfly-shaped endocrine organ located at the base of the throat, just below the Adam´s apple. Its function is to concentrate dietary iodine from the bloodstream and produce thyroid hormones, which have

Treatment of elderly patients with pancreatic cancer

Our publication is about elderly patients’ treatment evaluation for pancreatic cancer in the United States. This is a Surveillance, Epidemiology, and End Results (SEER)-Medicare analysis of patients above age of 65 who have Medicare and were treated

The discovery of anticancer compounds as a highly potent and selective Cyclin-Dependent Kinases 4 and 6 inhibitors

2D model of Abemaciclib bound to the active site of CDK6

Cell cycle is a highly regulated process that leads to the transition from quiescence or cytokinesis to cell proliferation through its checkpoints ensures genome stability. More importantly, cyclins and cyclin-dependent kinases (Cdks) play an important role in

Counting choline: why this nutrient is important and how we can measure it

Simplified schematic of our new colorimetric method for measuring choline and phosphocholine

Choline is an important nutrient for the growth and sustenance of living things, from humans to bacteria. Cells covert choline into phosphocholine via the activity of the enzyme choline kinase, and a change of other enzyme mediated