Tag Archives: cancer

Leptomeningeal metastasis in lung cancer

Leptomeningeal metastasis is the spread of cancer cells to the membranes surrounding the brain and spinal cord as well as the cerebrospinal fluid (CSF). This occurs in 3-5% of patients with non-small cell lung cancer (NSCLC), the

The needs of carers of blood cancer survivors: are there differences between Australia rural and urban dwellers?

As cancer treatments are increasingly delivered on an outpatient basis, the burden on partners, relatives and friends or support persons increases. Such people play a critical role in helping cancer patients manage their care. This can take

Adopting mammary development gameplay in breast cancer initiation and progression

The process by which the breast changes during puberty and lactation is incredibly unique. Those changes are essential for the functional mammary gland. These changes are triggered and orchestrated by hormones. Such hormonal changes start during pregnancy

Got blood!

Blood has been recognized as a life giving force from time immemorial. The first recorded attempt at human to human transfusion was recorded in 1492 when Pope Innocent VII succumbed in an attempt at a transfusion. Successful

The importance of immature cancer cells in predicting patient outcome

The word “cure” for breast or any other type of cancer might be unfair to a patient since this will give the individual a false sense of comfort. The misuse of `cure’ is evident in breast cancer

Negative regulators of cell death signalling pathways in cancer

Cancer is a primary cause of human death with a global economic toll of around US$1.4 trillion each year. It is estimated that about 12 million people will yearly die of cancer by 2030. Conventional cancer therapies such

Opium use increases the chance of pancreas cancer in a large population-based study

Pancreas cancer is a common cancer with few treatment options and as a result is associated with considerably reduced chances of survival for the patients. Several factors such as obesity, diabetes, and smoking (including smokeless and other

How can we make nanoparticles more effective against cancer?

Chemotherapy is an integral part of the present cancer treatment paradigm, despite its common and severe side effects. Nanotechnology provides a plethora of promising avenues for overcoming chemotherapy limitations. Drug encapsulation within nanoparticles helps to retain it

Tissue-specific MED1 LxxLL motifs play critical roles in HER2-driven breast cancers

Estrogen Receptor (ER)  is a nuclear hormone receptor that plays important roles in normal mammary gland development as well as breast cancer growth and metastases. In a breast cancer setting, when ER is bound by estradiol, there is

Potential biomarkers of CDK4/6 inhibitors in HR-positive advanced breast cancer

Thanks to the development of endocrine therapy, the mortality rate of estrogen receptor (ER)-positive breast cancer patients has been decreased drastically. In spite of the improvement, however, relapse and progression that are driven by different mechanisms are

A new strategy against cancer cells. Targeting the Rho-GTPases interactions: The case of the new compound 1A116

For the last decades scientist have been working hard to find cancer´s Achilles heel to design and develop more specific and efficacious therapeutic strategies for cancer. It has become clear that altered cell signaling is a key

Oncogenic role of CircPVT1 in head and neck squamous cell carcinoma

Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs that have recently shown to behave as gene regulators in eukaryotic cells, extending our previous knowledge regarding the diversity and complexity of the transcriptome. Nowadays, circRNAs have

A new strategy to deliver anti-cancer nanodrugs and decrease their toxic side effects by temporarily blunting the RES uptake using Intralipid®

Nanodrugs, or nanotechnology-based therapeutics, show great promise for treating a number of diseases, including cancer. However, an analysis of the literature from the past 10 years finds that in studies of cancer nanodrugs, a very small fraction

Can we treat cancer by targeting Treg subset without causing autoimmune disease?

The regulatory T cells (Tregs), are a type of CD4+ T cells that suppress the potentially adverse effect of the immune system and prevent autoimmune disease. Although they play a central role in maintaining self-tolerance, Tregs also

When the immune system is away, biliary cancer cells may come back to play

Tumours of the biliary tract (BTC) develop from the epithelium of bile ducts located inside and outside the liver and in the gallbladder. Surgery is the only curative treatment available. However, tumours often come back after surgery

Fasting blood glucose and prostate cancer: A meta-analysis of dose-response

Prostate cancer (PCa) is the most common cancer, and third leading cause of cancer deaths, in American men. So far, only a few well-established risk factors, including ageing and being racially black, are thought to be associated

Gamma-tubules — novel filaments in the fight against cancer

The word skeleton sounds very significant, and indeed humans could not exist without a skeleton! Similarly, a cellular skeleton or cytoskeleton is crucial for the functions of a cell. Several different types of cytoskeleton have been identified

A novel biomarker for oral cancer

Tongue squamous cell carcinoma (TSCC) is the most predominant form of oral cancer in developed countries with varying incidence in developing countries wherein diverse etiological factors such as chewing betel-quid comprising betel leaf, areca nut and slaked

Colorectal cancer and enteric neurons: Should tumors be nervous?

Colorectal cancer (CRC) is one of the most frequent types of cancer in the world and is associated with a high mortality rate with over 700.000 deaths per year. Throughout the past decades, the development of CRC

Acridone-pyrimidine hybrid molecules: potential anticancer agents

Cancer is one of the world’s most pressing challenge to research community and leading cause of death. As per the 13th report of American Science of Clinical Oncology, 14 million people are diagnosed with cancer every year.