Tag Archives: cancer

Specific and non-specific biomarkers in neuroendocrine gastroenteropancreatic tumors

Neuroendocrine tumors (NETs) are a heterogeneous group of rare malignancies that can arise in almost all organs, although gastroenteropancreatic site (GEP) is the most common. Symptoms are rarely specific, and clinical manifestations may be evident only in

A molecular passport authorizes intracellular travel for a potential cancer therapy antibody

AoS. A Molecular Passport Authorizes Intracellular Travel for a Potential Cancer.

Whether from external environmental factors or spontaneous intracellular processes, the DNA in our cells is under constant bombardment by DNA damage. Because unrepaired DNA damage can cause cell death, our cells have evolved vital mechanisms to repair

Allosteric degraders of EGFR leading to cancer cell detachment-promoted death

AoS. Allosteric Degraders of EGFR Leading to Cancer.

Epidermal growth factor receptor (EGFR) allosteric tyrosine kinase inhibitors (TKIs) have emerged as a therapeutic option for overcoming drug resistance in cancer. We have developed furfuryl derivatives of 4-allyl-5-[2-(4-alkoxyphenyl)-quinolin-4-yl]-4H-1,2,4-triazole-3-thiol and have shown that these compounds bind to

Turning on neuronal gene programs in prostate cancer cells

AoS. Turning on neuronal gene programs in prostate cancer cells

Cancer of the prostate gland is a common malignancy afflicting males worldwide. This cancer is the second deadliest amongst male in United States, with most of the mortality resulting from aggressive, advanced stage, metastatic disease. Prostate cancer

miRNA, the inconspicuous but key player in the development of cervical cancer

Cervical cancer is among the top three cancers affecting women below 45 years in several countries. Both the alterations and modification in deoxyribonucleic acid (DNA) sequences play a critical role in the onset and progression of cervical

Metformin improves pancreatic cancer and lymphoma outcomes in DM2 patients

AoS. Metformin improves pancreatic cancer and lymphoma outcomes in DM2 patients

Type 2 diabetics are at increased risk of cancer in part because of increased insulin in the blood from insulin resistance. Insulin and its related growth factor IGF-1 can stimulate cell growth through the Ras-Raf-MEK-ERK or the

Insight into the needs of thyroid cancer patients before surgery

AoS. Insight into the Needs of Thyroid Cancer Patients Before Surgery

The thyroid is a butterfly-shaped gland in the neck below the Adam’s apple. It produces hormones that help influence our metabolism and normal development. Over the last 30 years, the number of new thyroid cancer diagnoses has

California has changed social norms, dramatically reducing smoking behavior and lung cancer mortality

The rapid rise in the dependency on cigarette smoking in the United States occurred in the first half of the 20th century fueled by large mass media marketing campaigns and the provision of free cigarettes to troops

Normal and abnormal mucus – what do the mucins in colorectal cancer tell us?

Free compartments of all of the secretory epithelia are covered by mucus, working as a physical barrier, as well as first line of defence from harmful factors, such as bacteria, viruses and toxins. It is a “trap”

A new strategy for immune manipulation of advanced solid cancers

A new strategy for immune manipulation of advanced solid cancers. AoS

The biological cancer hallmarks and the current model In the updated ongoing model, genomic instability and inflammation are the basis of all the cancer hallmarks: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality,

Altered methylation in Breast Cancer in very young women

Altered methylation in Breast Cancer in very young women. AoS

Breast cancer has the highest incidence rate of all cancers in women worldwide. Although early breast cancer generally has an excellent prognosis, breast cancer in young women (under the age of 35) is associated with a high

Kelp extracts and their pharmaceutical properties

Kelp extracts and their pharmaceutical properties. AoS

Kelps are a specific type of large brown seaweeds that generally grow on rocky, shallow, nutrient-rich ocean water. The most common examples of kelps found in the South African coastlines include Ecklonia maxima (sea bamboo) (Fig. 1), Ecklonia

A new link between oxidant stress and lung cancer

A new link between oxidant stress and lung cancer. AoS

DNA repair protects our cells from conditions that cause damage to the genome, which can become a threat to the maintenance and function of our tissues. Our cells have a variety of DNA repair systems.  Most frequent

Enlightening the importance of the NDRGs in the (cancerous) gut

Enlightening the importance of the NDRGs in the (cancerous) gut. AoS

The gastrointestinal (GI) tract is one of the most complex organs of the human body. With its approximate 5m length, a diversity of specialized epithelial cell types (the ‘lining’ of the GI tract), about 80% of our

64Cu and 67Cu radionuclide to diagnose and treat of cancer: Experimental and theoretical Production yields

Experimental and theoretical Production yields. AoS

As the number of patients suffering from different cancers has been increased, researchers have evaluated several ways to diagnose and treat these abnormalities. In this regard, application of radionuclides is an interesting option through which some cancers

Thyroid hormone ratio and clinical outcome: results from the Toreador Study

Overall survival of metastatic colon rectal cancer patients. AoS

From a physiopathological point of view patients with advanced solid cancer and neoplastic cachexia might be associated, in some way, with frail older patients, a well-known and extensively described multi-factorial clinical condition, characterized by increased catabolism and

An integrated genomics approach for identifying breast cancer patients with highly aggressive tumors

An integrated genomics approach for identifying breast cancer patients. AoS

Breast cancer is the most common cancer in women with over 2 million new cases worldwide in 2018. Three kinds of receptors are usually found on the surface of breast cancer cells: a receptor for female hormone

What do patients and healthcare professionals “tweet” about brachytherapy?

Word Cloud of Patient Tweets about Brachytherapy. Atlas of Science

Many patients post on Twitter about their healthcare experiences. Patients with cancer are especially active on Twitter, and studies have found that sharing experiences online can reduce feelings of isolation. Healthcare professionals also frequently post on Twitter.

FLYWCH1 is a novel transcriptional repressor for the cancer-causing Beta-catenin

There is no doubt that cancer is a devastating disease. However, restraining the cancerous cells from spreading throughout the body (invasion) will make it easier to control and possibly cure cancer. β-catenin is one of the proteins

More Paleolithic-like lifestyles and diets associated with lower colorectal cancer risk

More Paleolithic-like lifestyles and diets associated with lower colorectal cancer risk. Atlas of Science

Colorectal cancer (CRC) is the second leading cause of cancer deaths among women and men combined in the United States. CRC incidence (i.e., the rate of new diagnoses) varies about 20-fold across countries. The incidence among immigrants