Tag Archives: cancer

Keeping a clean house to suppress HER2+ breast tumor growth

Keeping a clean house to suppress HER2+ breast tumor growth

Autophagy (self-eating) is a process used by normal cells to keep a “clean house”. It degrades abnormal or damaged proteins and organelles, helps to fight infections and also provides energy during periods of fasting or exercise. Besides

A new biomarker for Triple negative breast cancer MCP-1 drives cancer invasiveness and metastasis

Model of MCP-1 action in breast cancer cells

Breast Cancer is the second leading cause of mortality in women in the United States. Breast cancer arise in the ducts of the mammary glands that produces milk in a lactating breast. Breast cancers usually express various

miR-146 and miR-155, two key modulators of the immune response and of the oncogenic transformation

miR-146 and miR-155, two key modulators of the immune response and of the oncogenic transformation

Micro-RNA (miRNAs or miRs) are small noncoding RNAs that negatively regulate protein coding gene transcripts and exert an important role in the control of gene expression. miRs are deregulated in many tumors and play an active role

Targeting cholesterol metabolism to suppress prostate cancer metastasis

Targeting cholesterol metabolism to suppress prostate cancer metastasis

Metastatic prostate cancer is the second leading cause of cancer death in men worldwide. Prostate cancer itself is one of the most common cancers in men. At the early stages, localized prostate cancer usually grows slowly and

Chronic pancreatitis: an inflammatory disease of pancreas

Chronic Pancreatitis: An Inflammatory Disease of Pancreas

Pancreas is very important organ in our body and it is located in the abdomen behind the stomach. Pancreas is a gland and secrets some chemicals called enzymes. It is a leaf like structure and divided in

Enrichment, quantification and glycan analysis of prostate cancer oncomarker in a single step

In recent decades, there is an increasing trend in prostate cancer occurrence and mortality worldwide, caused partly by a more available diagnostics, prolonged life period but also increased risk factors present in the environment. Most commonly, age

Targeting microRNAs for thyroid cancer therapy

Schematic model explaining the oncogenic actions of miR-146b and the consequences of its inhibition in thyroid cancer

The thyroid gland is a small butterfly-shaped endocrine organ located at the base of the throat, just below the Adam´s apple. Its function is to concentrate dietary iodine from the bloodstream and produce thyroid hormones, which have

Treatment of elderly patients with pancreatic cancer

Our publication is about elderly patients’ treatment evaluation for pancreatic cancer in the United States. This is a Surveillance, Epidemiology, and End Results (SEER)-Medicare analysis of patients above age of 65 who have Medicare and were treated

The discovery of anticancer compounds as a highly potent and selective Cyclin-Dependent Kinases 4 and 6 inhibitors

2D model of Abemaciclib bound to the active site of CDK6

Cell cycle is a highly regulated process that leads to the transition from quiescence or cytokinesis to cell proliferation through its checkpoints ensures genome stability. More importantly, cyclins and cyclin-dependent kinases (Cdks) play an important role in

Counting choline: why this nutrient is important and how we can measure it

Simplified schematic of our new colorimetric method for measuring choline and phosphocholine

Choline is an important nutrient for the growth and sustenance of living things, from humans to bacteria. Cells covert choline into phosphocholine via the activity of the enzyme choline kinase, and a change of other enzyme mediated

How does chromium cause lung cancer? Resistance to cellular stress

How does chromium cause lung cancer

Lung cancer is the deadliest form of cancer in both men and women. One cause of lung cancer is occupational exposure to heavy metals. Extremely useful in several industries, heavy metals have become widespread environmental pollutants over

Leptomeningeal metastasis in lung cancer

Leptomeningeal metastasis is the spread of cancer cells to the membranes surrounding the brain and spinal cord as well as the cerebrospinal fluid (CSF). This occurs in 3-5% of patients with non-small cell lung cancer (NSCLC), the

The needs of carers of blood cancer survivors: are there differences between Australia rural and urban dwellers?

As cancer treatments are increasingly delivered on an outpatient basis, the burden on partners, relatives and friends or support persons increases. Such people play a critical role in helping cancer patients manage their care. This can take

Adopting mammary development gameplay in breast cancer initiation and progression

The process by which the breast changes during puberty and lactation is incredibly unique. Those changes are essential for the functional mammary gland. These changes are triggered and orchestrated by hormones. Such hormonal changes start during pregnancy

Got blood!

Blood has been recognized as a life giving force from time immemorial. The first recorded attempt at human to human transfusion was recorded in 1492 when Pope Innocent VII succumbed in an attempt at a transfusion. Successful

The importance of immature cancer cells in predicting patient outcome

The word “cure” for breast or any other type of cancer might be unfair to a patient since this will give the individual a false sense of comfort. The misuse of `cure’ is evident in breast cancer

Negative regulators of cell death signalling pathways in cancer

Cancer is a primary cause of human death with a global economic toll of around US$1.4 trillion each year. It is estimated that about 12 million people will yearly die of cancer by 2030. Conventional cancer therapies such

Opium use increases the chance of pancreas cancer in a large population-based study

Pancreas cancer is a common cancer with few treatment options and as a result is associated with considerably reduced chances of survival for the patients. Several factors such as obesity, diabetes, and smoking (including smokeless and other

How can we make nanoparticles more effective against cancer?

Chemotherapy is an integral part of the present cancer treatment paradigm, despite its common and severe side effects. Nanotechnology provides a plethora of promising avenues for overcoming chemotherapy limitations. Drug encapsulation within nanoparticles helps to retain it

Tissue-specific MED1 LxxLL motifs play critical roles in HER2-driven breast cancers

Estrogen Receptor (ER)  is a nuclear hormone receptor that plays important roles in normal mammary gland development as well as breast cancer growth and metastases. In a breast cancer setting, when ER is bound by estradiol, there is