Tag Archives: cancer
Lipid nanoparticles loaded with CpG oligonucleotides exert an antitumor effect via immunomodulation
Since the emergence of immune checkpoint inhibitors (ICIs), cancer immunotherapy has dramatically developed. However, its drawback is the low overall response rate to its therapeutic effect. The efficacy of immunotherapy is suggested to depend on the immune
Molecular classification of glioma stem cells
Comprehensive genetic analysis of glioblastomas by The Cancer Genome Atlas (TCGA) has proposed a new classification based on genetic abnormalities. The characteristic genetic abnormalities identified in the TCGA are promising candidates for novel molecularly targeted therapies, and
Can AI Solve The World’s Addiction Problem?
Addiction is a global problem that affects millions of people, causing significant physical, emotional, and financial harm. Despite decades of research, effective treatments for addiction remain elusive, and traditional approaches often fall short of achieving long-term recovery.
Defects in mismatch repair increase cancer risk and influence treatment selection
Microsatellites are formed by 1-6 nucleotide base pairs that are repeated in direct order 5-50 times. Repetitive DNA including microsatellites are mainly present in non-coding DNA regions that occupy more than 97% of the nuclear DNA. They
How PET ameliorates 90-Yttrium therapy in inoperable liver cancer patients?
Increased synthesis of blood vessels and blood supply are essential characteristics of a tumor to secure nutrient delivery and growth. One of the treatment options for inoperable liver cancer (hepatocellular carcinoma, HCC) is to apply a form of
Ti3C2-MXene based fluorescent biosensor for rapid detection of lung cancer biomarker
Over the last decade, zero-dimensional (0D) and two-dimensional (2D) nanomaterials such as nanostructured metals, and graphene derivatives delivered an extraordinary impact as fluorescence quenchers or energy acceptors in developing fluorescent biosensors. However, these OD/2D materials have a
Exercise inhibits cancer: the mechanosensitive state of tumor cells
Surprisingly, researchers find that tumor cells are sensitive to mechanical stresses. This may provide new ways to treat cancers without the severe side-effects of many therapies. Because mechanosensitivity of cancer cells is found quite generally, it appears
Arming macrophages to stop cancer progression
Macrophages are a type of immune cells that fight infection and support tissue remodeling. They are best known as phagocytes which engulf bacteria and damaged cells stimulating other immune cells. In addition, macrophages assist wound healing processes
Eavesdropping on cell communications to treat cancer with drug resistance
An estimated 19.3 million new cancer cases and almost 10 million cancer deaths occurred worldwide in 2020. It’s estimated that one in three individuals will be diagnosed with some kind of cancer in their lifetime. When cancer
The complementary anti-inflammatory and anticancer activity of hydroxycinnamic acid derivatives
Inflammation is an important and extremely complex biological process involving a high number of mediators responsible for the activation of multiple cascades, providing a wide range of possible targets for the pharmacological treatment of inflammatory-related diseases. It
Does tangential radiation for breast cancer cover internal mammary nodes?
Breast cancer is one of the most common cancers in women in the United States. Radiation is a very commonly used treatment modality for breast cancer: it is offered to nearly all patients after lumpectomy (removal of
Specific and non-specific biomarkers in neuroendocrine gastroenteropancreatic tumors
Neuroendocrine tumors (NETs) are a heterogeneous group of rare malignancies that can arise in almost all organs, although gastroenteropancreatic site (GEP) is the most common. Symptoms are rarely specific, and clinical manifestations may be evident only in
A molecular passport authorizes intracellular travel for a potential cancer therapy antibody
Whether from external environmental factors or spontaneous intracellular processes, the DNA in our cells is under constant bombardment by DNA damage. Because unrepaired DNA damage can cause cell death, our cells have evolved vital mechanisms to repair
Allosteric degraders of EGFR leading to cancer cell detachment-promoted death
Epidermal growth factor receptor (EGFR) allosteric tyrosine kinase inhibitors (TKIs) have emerged as a therapeutic option for overcoming drug resistance in cancer. We have developed furfuryl derivatives of 4-allyl-5-[2-(4-alkoxyphenyl)-quinolin-4-yl]-4H-1,2,4-triazole-3-thiol and have shown that these compounds bind to
Turning on neuronal gene programs in prostate cancer cells
Cancer of the prostate gland is a common malignancy afflicting males worldwide. This cancer is the second deadliest amongst male in United States, with most of the mortality resulting from aggressive, advanced stage, metastatic disease. Prostate cancer
miRNA, the inconspicuous but key player in the development of cervical cancer
Cervical cancer is among the top three cancers affecting women below 45 years in several countries. Both the alterations and modification in deoxyribonucleic acid (DNA) sequences play a critical role in the onset and progression of cervical
Metformin improves pancreatic cancer and lymphoma outcomes in DM2 patients
Type 2 diabetics are at increased risk of cancer in part because of increased insulin in the blood from insulin resistance. Insulin and its related growth factor IGF-1 can stimulate cell growth through the Ras-Raf-MEK-ERK or the
Insight into the needs of thyroid cancer patients before surgery
The thyroid is a butterfly-shaped gland in the neck below the Adam’s apple. It produces hormones that help influence our metabolism and normal development. Over the last 30 years, the number of new thyroid cancer diagnoses has
California has changed social norms, dramatically reducing smoking behavior and lung cancer mortality
The rapid rise in the dependency on cigarette smoking in the United States occurred in the first half of the 20th century fueled by large mass media marketing campaigns and the provision of free cigarettes to troops
Normal and abnormal mucus – what do the mucins in colorectal cancer tell us?
Free compartments of all of the secretory epithelia are covered by mucus, working as a physical barrier, as well as first line of defence from harmful factors, such as bacteria, viruses and toxins. It is a “trap”
