Tag Archives: cancer

Altered expression of a protein in high vs. low spreading cancer cells

Breast cancer cells start off growing in the breast and end up spreading to the lung, liver, bones and brain. This spreading to another organ is called metastasis and is the major cause of patient death due

p53 gene reactivation reverts hypoxic resistance in KRAS mutant tumor cells decreasing glucose uptake

When growing distant from primary blood supply sites, tumor cells face hypoxia characterized by niches restricted in oxygen and glucose. Cells acquiring resistant to hypoxic stress undergo metabolic re – programming, and increased resistance to 3 –

A new extracellular role for miR-939 in triple negative breast cancer

Triple negative breast cancer (TNBC) is defined as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) negative breast carcinomas (BC). Unfortunately, this kind of tumor is characterized by poor prognosis, high

Simultaneous glucose fasting and autophagy inhibition enhances chemotherapy treatment

If you could cut your risk of developing cancer, diabetes, and heart disease, rejuvenate your immune system, and potentially live longer – would you do it? What if the answer to potentially save your life is as

Mutant TP53 disrupts age-related accumulation patterns of somatic mutations in multiple cancer types

Most cancers are driven by somatic mutations in proto-oncogenes and tumor suppressor genes. Genetic changes in a tumor may accumulate in the tissue self-renewal phase prior to neoplasm. The risk of sporadic mutations increases with age. In

Pancreatic cancer stem cells: fatty acid synthesis and mevalonate pathways are implicated in their survival

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high metastatic potential. The disease is the fourth leading cause of cancer-related deaths in the USA, and is projected to be the second one by 2030, due

New therapy for the treatment of childhood bone cancer

Cancer in children and young adults is rare, with survival rates being very high, mainly depending on the treatment. The biggest proportion of this diagnosis will be on leukaemia and brain tumours, with just about 3% of

International Conference on Oncology and Cancer Therapeutics. Chicago, Illinois, USA. October 30- November 01, 2017

Allied Academies invites all the participants from all over the world to attend “International Conference on Oncology and Cancer Therapeutics” held in Chicago, Illinois, USA at October 30- November 1, 2017 which includes prompt Keynote Presentations, Special

A novel mechanism by which viral integration drives cancer

Human papillomaviruses (HPV) are a group of about 200 DNA viruses that infect the skin, or the mucous membranes of the anus, genitals and oropharyngeal cavity. HPV infections are the most common sexually transmitted disease in the

Hospital readmission after head and neck microvascular reconstruction

Unplanned readmissions are associated with decreased healthcare quality and increased costs. This nationwide study examines causes for unplanned readmission among head and neck cancer patients undergoing immediate microsurgical reconstruction. Patients undergoing head and neck tumor resection with

Proteins regulate cancer cell attachment

Aggressive cancer cells are able to leave their original site and invade other tissues. In order for these cells to do this, they must have some way of moving around. This means that a cancer cell must

Prostate-specific antigen 1.5: The new screening protocol

Prostate cancer is the leading cause of cancer-related death in American men. Tragically, once the disease is spread beyond the prostate gland, therapies become very limited and survival is poor. Like other cancers, prostate cancer can recur

A new three-headed, long-tailed molecular beast eats cancer

We made and tested a series of new compounds containing three chemical rings and hooked them to long carbon tails. These new molecules killed a broad range of pediatric and adult cancer cells including neuroblastoma, osteosarcoma, malignant

Do all children have equal access to Phase I cancer trials?

Approximately 60% of pediatric cancer patients participate in clinical trials compared to only 5% of adult cancer patients.  These pediatric clinical trials have been instrumental in improving the 5-year survival rate of childhood and adolescent cancer patients

Identification of a new T cell regulator

T-cell receptor (TCR) signaling is mediated by the activation of protein-tyrosine kinases such as p56lck and ZAP-70. In mature T-cells, CD4 and CD8 molecules bind to p56lck which then phosphorylates the intracellular immune-receptor tyrosine-based activation motifs (ITAM)

Atomic structures of telomerase shed light into the mechanism of telomere replication

Telomeres comprise the six nucleotide repeats at the end of eukaryotic chromosomes and they are essential for the faithful replication and protection of our genome. Significant telomere attrition forces the cells to enter a dormant state to