Tag Archives: cardiac

Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment

Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes mellitus (DM) that is strongly associated with approximately five-fold increased risk of cardiovascular mortality. CAN manifests in a spectrum of things, ranging from resting tachycardia and fixed

Decreased vagally-mediated heart rate variability in a conditional NPY Y1 receptor knockout mouse

Neuropeptide Y (NPY) is a protein involved in the complex regulation of a variety of physiological functions that range from feeding to emotions. In the central nervous system NPY is able to influence autonomic nervous system regulation

Women less likely than men to stick to cardiac rehab programs

Heart disease remains the leading cause of death in North America and it occurs more in women than in men. After a sudden heart event, women are more likely than men to die, more likely to have

Nuclear cardiac imaging: the “old grandma” has still something to say

Ischemic heart disease (IHD) remains one of the most relevant predictors of overall patients’ mortality and a major determinant of sanitary and social costs. Different strategies have been proposed for the early diagnosis of myocardial ischemia, a

Nerves are required to repair the injured heart

Cardiovascular diseases (CVD), such as heart attack, are responsible for approximately 18 million deaths each year, which accounts for more than 30% of all deaths worldwide. CVD is the single greatest cause of death in humans killing

Safety of quinlones reviewed by FDA

The fluoroquinolone antibiotics are a commonly prescribed group of agents which includes ciprofloxacin, levofloxacin and moxifloxacin. They are used in a wide range of infections. Late last year FDA convened an Advisory Committee to review the information

Cardiac device lead clots and cardiac ablation: mitigating the potential for Peri-procedural stroke?

An increasing number of patients receive implanted cardiac devices to ensure adequate beating of the heart ( pacemakers ), prevent sudden cardiac death from life – threatening rhythm disturbances (implantable cardioverter – defibrillator (ICDs) ), as well

A transcriptomic approach for cardiac (heart) safety assessment

New drug discovery relies on several phases of safety assessment. One such prominent in vitro safety assessment assay is the “hERG potassium channel assay” for cardiac safety. If a compound blocks the hERG potassium channel in a

The blue coma: the role of methylene blue in unexplained coma after cardiac surgery

More than 10% of U.S. citizens aged 12 and over take antidepressant medication, and this percentage is mirrored in many other countries. The most commonly prescribed antidepressant drugs are Selective Serotonin Reuptake Inhibitors (SSRIs), whose mechanism of

The use of multisite ultrasound in cardiac arrest – the SESAME-protocol

Cardiac arrest is the most critical emergency. The sudden interruption of oxygen supply damages the brain after some minutes. Finding a cause for efficiently fixing the problem is the main target of the frontline physician. Ultrasound is

ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling

Cardiovascular diseases are disorders of the heart and blood vessels which are leading to heart failure. Cardiovascular diseases correspond to 30% of all deaths in the world. The molecular processes that undergone from a healthy heart to

Post electric shock cardiac arrest, does it differ?

Sudden cardiac arrest (CA) is a medical emergency that immediately causes circulatory failure with loss of consciousness; absence of breathing; low blood pressure with no pulses; and no heart sounds. The most common causes of CA are electrical

Two essential cardiac disorders improvement in patients with hypertrophic cardiomyopathy

Sudden cardiac death and heart failure are the most serious complications of hypertrophic cardiomyopathy ( HCM ). To prevent these serious complications, 2 essential cardiac disorders in patients with HCM must be corrected. These are left ventricular (LV)

The effect of a hydrogen sulfide releasing molecule on the cold storage of livers from dead donor rats

The liver is the largest organ inside our body and, as long as it keeps healthy, it will be in charge of a wide range of mechanisms that are essential for life. Liver will filter the blood

What does the PROMISE trial mean for cardiac CT?

Current guidelines recommend functional testing (FT) such as exercise tests or nuclear tests (with very high radiation exposures) to identify those patients who have chest pain that may benefit from stents or bypass surgery.  Unfortunately, a vast

Survivals in pediatric cardiac tamponade caused by central venous catheters

Pediatric central venous catheter (CVC) placement is used for fluid or drug administration and is useful for hemodynamic (the fluid dynamics of flow) management in cardiac surgery but associated with complications such as rare but serious cardiac

PDE2 is a potential new target for the treatment of cardiac hypertrophy

Heart failure is one of the leading causes of death in the Western World today. It typically involves a deficiency of the heart to provide sufficient blood flow and/or blood pressure to meet the requirements of the

Busy traffic – risk of having cardiac disease

Air pollution from vehicles has been related to cause respiratory and cardiovascular diseases. There are many pollutants; most harmful of them is considered to be particulate matter (PM). Small in size, they are composed of toxic heavy

Fat content surrounding your heart may cause your arrhythmia to recur

Epicardial adipose tissue (EAT) is a metabolically active fat depot surrounding the heart. It is located between the outer wall of myocardium and the visceral pericardium. Its proximity to cardiac structures (i.e. vessels, myocardium) and its shared

Cardiac atrial appendage stem cells: bright cells for a bright future for patients with ischemic heart disease

Ischemic heart disease is still one of the major causes of global morbidity and mortality. Although significant improvements in medical and surgical treatments have been accomplished over the last few decades, these are still not able to